The Connectome and Chemo-Connectome Databases for Mice Brain Connection Analysis

The various brain functions rely on the intricate connection networks and certain molecular characteristics of neurons in the brain. However, the databases for the mouse brain connectome and chemo-connectome are still inadequate, hindering the brain circuital and functional analysis. Here, we create...

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Autores principales: Wang, Yang, Liu, Zhixiang, Sun, Da, Sun, Leqiang, Cao, Gang, Dai, Jinxia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Neuroanatomy
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9218099/
https://www.ncbi.nlm.nih.gov/pubmed/35756500
http://dx.doi.org/10.3389/fnana.2022.886925
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author Wang, Yang
Liu, Zhixiang
Sun, Da
Sun, Leqiang
Cao, Gang
Dai, Jinxia
author_facet Wang, Yang
Liu, Zhixiang
Sun, Da
Sun, Leqiang
Cao, Gang
Dai, Jinxia
author_sort Wang, Yang
collection PubMed
description The various brain functions rely on the intricate connection networks and certain molecular characteristics of neurons in the brain. However, the databases for the mouse brain connectome and chemo-connectome are still inadequate, hindering the brain circuital and functional analysis. Here, we created mice brain connectome and chemo-connectome databases based on mouse brain projection data of 295 non-overlapping brain areas and in situ hybridization (ISH) data of 50 representative neurotransmission-related genes from the Allen Brain Institute. Based on this connectome and chemo-connectome databases, functional connection patterns and detailed chemo-connectome for monoaminergic nuclei were analyzed and visualized. These databases will aid in the comprehensive research of the mouse connectome and chemo-connectome in the whole brain and serve as a convenient resource for systematic analysis of the brain connection and function.
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spelling pubmed-92180992022-06-24 The Connectome and Chemo-Connectome Databases for Mice Brain Connection Analysis Wang, Yang Liu, Zhixiang Sun, Da Sun, Leqiang Cao, Gang Dai, Jinxia Front Neuroanat Neuroanatomy The various brain functions rely on the intricate connection networks and certain molecular characteristics of neurons in the brain. However, the databases for the mouse brain connectome and chemo-connectome are still inadequate, hindering the brain circuital and functional analysis. Here, we created mice brain connectome and chemo-connectome databases based on mouse brain projection data of 295 non-overlapping brain areas and in situ hybridization (ISH) data of 50 representative neurotransmission-related genes from the Allen Brain Institute. Based on this connectome and chemo-connectome databases, functional connection patterns and detailed chemo-connectome for monoaminergic nuclei were analyzed and visualized. These databases will aid in the comprehensive research of the mouse connectome and chemo-connectome in the whole brain and serve as a convenient resource for systematic analysis of the brain connection and function. Frontiers Media S.A. 2022-06-09 /pmc/articles/PMC9218099/ /pubmed/35756500 http://dx.doi.org/10.3389/fnana.2022.886925 Text en Copyright © 2022 Wang, Liu, Sun, Sun, Cao and Dai. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroanatomy
Wang, Yang
Liu, Zhixiang
Sun, Da
Sun, Leqiang
Cao, Gang
Dai, Jinxia
The Connectome and Chemo-Connectome Databases for Mice Brain Connection Analysis
title The Connectome and Chemo-Connectome Databases for Mice Brain Connection Analysis
title_full The Connectome and Chemo-Connectome Databases for Mice Brain Connection Analysis
title_fullStr The Connectome and Chemo-Connectome Databases for Mice Brain Connection Analysis
title_full_unstemmed The Connectome and Chemo-Connectome Databases for Mice Brain Connection Analysis
title_short The Connectome and Chemo-Connectome Databases for Mice Brain Connection Analysis
title_sort connectome and chemo-connectome databases for mice brain connection analysis
topic Neuroanatomy
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9218099/
https://www.ncbi.nlm.nih.gov/pubmed/35756500
http://dx.doi.org/10.3389/fnana.2022.886925
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