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ARIH2 regulates the proliferation, DNA damage and chemosensitivity of gastric cancer cells by reducing the stability of p21 via ubiquitination

Ariadne homolog 2 (ARIH2) is a key member of the RING-between-RING (RBR) E3 ligase family, which is characterized by an RBR domain involved in the polyubiquitination process. However, the molecular mechanism and biological function of ARIH2 in the pathogenesis of gastric cancer remain unclear. In th...

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Detalles Bibliográficos
Autores principales:	Geng, Shengjun, Peng, Wen, Wang, Xue, Hu, Xiaosong, Liang, Hanghua, Hou, Jianbing, Wang, Feng, Zhao, Gaichao, Lü, Muhan, Cui, Hongjuan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9218151/ https://www.ncbi.nlm.nih.gov/pubmed/35732617 http://dx.doi.org/10.1038/s41419-022-04965-9

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