Cargando…

Fat Attenuation Index of Renal Cell Carcinoma Reveals Biological Characteristics and Survival Outcome

PURPOSE: The computed tomography fat attenuation index (FAI) is an ideal quantifiable imaging factor to identify the inflammation degree of peri-tumor adipose tissue. We aimed to verify whether FAI could reflect peri-tumor adipose inflammation, predict the survival outcome of renal cell carcinoma (R...

Descripción completa

Detalles Bibliográficos
Autores principales: Wang, Hongkai, Wei, Yu, Hu, Xiaoxin, Pan, Jian, Wu, Junlong, Wang, Beihe, Zhang, Hailiang, Shi, Guohai, Liu, Xiaohang, Zhao, Jinou, Zhu, Yao, Ye, Dingwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9218210/
https://www.ncbi.nlm.nih.gov/pubmed/35756650
http://dx.doi.org/10.3389/fonc.2022.786981
_version_ 1784731831711563776
author Wang, Hongkai
Wei, Yu
Hu, Xiaoxin
Pan, Jian
Wu, Junlong
Wang, Beihe
Zhang, Hailiang
Shi, Guohai
Liu, Xiaohang
Zhao, Jinou
Zhu, Yao
Ye, Dingwei
author_facet Wang, Hongkai
Wei, Yu
Hu, Xiaoxin
Pan, Jian
Wu, Junlong
Wang, Beihe
Zhang, Hailiang
Shi, Guohai
Liu, Xiaohang
Zhao, Jinou
Zhu, Yao
Ye, Dingwei
author_sort Wang, Hongkai
collection PubMed
description PURPOSE: The computed tomography fat attenuation index (FAI) is an ideal quantifiable imaging factor to identify the inflammation degree of peri-tumor adipose tissue. We aimed to verify whether FAI could reflect peri-tumor adipose inflammation, predict the survival outcome of renal cell carcinoma (RCC), and discover transcriptomic features of tumor tissues and adjacent adipocytes. MATERIALS AND METHODS: Two clinical cohorts (Fudan University Shanghai Cancer Center [FUSCC] cohort [n=129] and TCGA cohort [n=218]) were used to explore the association between FAI and clinical outcome. A prospective cohort (n = 19) was used to discover the molecular phenotyping of peri-tumor adipose tissue and tumor tissue according to their FAI value. A clinical cohort (n = 32) in which patients received cyto-reductive surgery was used to reveal the dynamic change of FAI. RESULTS: A high peri-tumor FAI was significantly associated with a worse outcome in both the FUSCC (HR = 2.28, p = 0.01) and the TCGA cohort (HR = 2.24, p <0.001). The analysis of the RNA expression of paired RCC tissue and peri-tumor fat tissue showed synchronized alterations in pathways such as cytokine–cytokine receptor interaction and complement and coagulation cascades. RCC tissues showed significant alterations in the neuroactive ligand–receptor interaction pathway. Immune deconvolution analysis showed enhanced infiltration of macrophages in high FAI tumor tissues with a lower angiogenesis level. We also observed synchronous dynamic changes in FAI and tumor size after targeted therapy. CONCLUSION: In summary, FAI could be used in RCC to reflect the biological characteristics and tumor immune micro-environment of both the tumor and the peri-tumor adipose. High peri-tumor FAI had the potential to predict a worse survival outcome in various cohorts. This study demonstrates that the crosstalk exists between a tumor and its micro-environment and could be reflected easily by imaging procedures, which could facilitate clinical decision making.
format Online
Article
Text
id pubmed-9218210
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-92182102022-06-24 Fat Attenuation Index of Renal Cell Carcinoma Reveals Biological Characteristics and Survival Outcome Wang, Hongkai Wei, Yu Hu, Xiaoxin Pan, Jian Wu, Junlong Wang, Beihe Zhang, Hailiang Shi, Guohai Liu, Xiaohang Zhao, Jinou Zhu, Yao Ye, Dingwei Front Oncol Oncology PURPOSE: The computed tomography fat attenuation index (FAI) is an ideal quantifiable imaging factor to identify the inflammation degree of peri-tumor adipose tissue. We aimed to verify whether FAI could reflect peri-tumor adipose inflammation, predict the survival outcome of renal cell carcinoma (RCC), and discover transcriptomic features of tumor tissues and adjacent adipocytes. MATERIALS AND METHODS: Two clinical cohorts (Fudan University Shanghai Cancer Center [FUSCC] cohort [n=129] and TCGA cohort [n=218]) were used to explore the association between FAI and clinical outcome. A prospective cohort (n = 19) was used to discover the molecular phenotyping of peri-tumor adipose tissue and tumor tissue according to their FAI value. A clinical cohort (n = 32) in which patients received cyto-reductive surgery was used to reveal the dynamic change of FAI. RESULTS: A high peri-tumor FAI was significantly associated with a worse outcome in both the FUSCC (HR = 2.28, p = 0.01) and the TCGA cohort (HR = 2.24, p <0.001). The analysis of the RNA expression of paired RCC tissue and peri-tumor fat tissue showed synchronized alterations in pathways such as cytokine–cytokine receptor interaction and complement and coagulation cascades. RCC tissues showed significant alterations in the neuroactive ligand–receptor interaction pathway. Immune deconvolution analysis showed enhanced infiltration of macrophages in high FAI tumor tissues with a lower angiogenesis level. We also observed synchronous dynamic changes in FAI and tumor size after targeted therapy. CONCLUSION: In summary, FAI could be used in RCC to reflect the biological characteristics and tumor immune micro-environment of both the tumor and the peri-tumor adipose. High peri-tumor FAI had the potential to predict a worse survival outcome in various cohorts. This study demonstrates that the crosstalk exists between a tumor and its micro-environment and could be reflected easily by imaging procedures, which could facilitate clinical decision making. Frontiers Media S.A. 2022-06-09 /pmc/articles/PMC9218210/ /pubmed/35756650 http://dx.doi.org/10.3389/fonc.2022.786981 Text en Copyright © 2022 Wang, Wei, Hu, Pan, Wu, Wang, Zhang, Shi, Liu, Zhao, Zhu and Ye https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Wang, Hongkai
Wei, Yu
Hu, Xiaoxin
Pan, Jian
Wu, Junlong
Wang, Beihe
Zhang, Hailiang
Shi, Guohai
Liu, Xiaohang
Zhao, Jinou
Zhu, Yao
Ye, Dingwei
Fat Attenuation Index of Renal Cell Carcinoma Reveals Biological Characteristics and Survival Outcome
title Fat Attenuation Index of Renal Cell Carcinoma Reveals Biological Characteristics and Survival Outcome
title_full Fat Attenuation Index of Renal Cell Carcinoma Reveals Biological Characteristics and Survival Outcome
title_fullStr Fat Attenuation Index of Renal Cell Carcinoma Reveals Biological Characteristics and Survival Outcome
title_full_unstemmed Fat Attenuation Index of Renal Cell Carcinoma Reveals Biological Characteristics and Survival Outcome
title_short Fat Attenuation Index of Renal Cell Carcinoma Reveals Biological Characteristics and Survival Outcome
title_sort fat attenuation index of renal cell carcinoma reveals biological characteristics and survival outcome
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9218210/
https://www.ncbi.nlm.nih.gov/pubmed/35756650
http://dx.doi.org/10.3389/fonc.2022.786981
work_keys_str_mv AT wanghongkai fatattenuationindexofrenalcellcarcinomarevealsbiologicalcharacteristicsandsurvivaloutcome
AT weiyu fatattenuationindexofrenalcellcarcinomarevealsbiologicalcharacteristicsandsurvivaloutcome
AT huxiaoxin fatattenuationindexofrenalcellcarcinomarevealsbiologicalcharacteristicsandsurvivaloutcome
AT panjian fatattenuationindexofrenalcellcarcinomarevealsbiologicalcharacteristicsandsurvivaloutcome
AT wujunlong fatattenuationindexofrenalcellcarcinomarevealsbiologicalcharacteristicsandsurvivaloutcome
AT wangbeihe fatattenuationindexofrenalcellcarcinomarevealsbiologicalcharacteristicsandsurvivaloutcome
AT zhanghailiang fatattenuationindexofrenalcellcarcinomarevealsbiologicalcharacteristicsandsurvivaloutcome
AT shiguohai fatattenuationindexofrenalcellcarcinomarevealsbiologicalcharacteristicsandsurvivaloutcome
AT liuxiaohang fatattenuationindexofrenalcellcarcinomarevealsbiologicalcharacteristicsandsurvivaloutcome
AT zhaojinou fatattenuationindexofrenalcellcarcinomarevealsbiologicalcharacteristicsandsurvivaloutcome
AT zhuyao fatattenuationindexofrenalcellcarcinomarevealsbiologicalcharacteristicsandsurvivaloutcome
AT yedingwei fatattenuationindexofrenalcellcarcinomarevealsbiologicalcharacteristicsandsurvivaloutcome