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Pre-clinical drug-drug interactions (DDIs) of gefitinib with/without losartan and selective serotonin reuptake inhibitors (SSRIs): citalopram, fluoxetine, fluvoxamine, paroxetine, sertraline, and venlafaxine

OBJECTIVE: To evaluate drug-drug interactions (DDIs) between gefitinib with/without losartan and selective serotonin reuptake inhibitors (SSRIs). METHODS: In vitro supersomes were used to identify CYP isoenzymes (CYP1A2, 2C9, 2C19, 2D6, and 3A4) involved in drug metabolism, and in vitro pooled cryop...

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Detalles Bibliográficos
Autores principales:	Luong, Thu-Lan T., Powers, Chelsea N., Reinhardt, Brian J., Weina, Peter J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9218239/ https://www.ncbi.nlm.nih.gov/pubmed/35756846 http://dx.doi.org/10.1016/j.crphar.2022.100112

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