DAP10 integration in CAR-T cells enhances the killing of heterogeneous tumors by harnessing endogenous NKG2D

Although chimeric antigen receptor T (CAR-T) cells have achieved remarkable successes in hematological malignancies, the efficacies of CAR-T cells against solid tumors remains unsatisfactory. Heterogeneous antigen expression is one of the obstacles on its effective elimination of solid cancer cells....

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Detalles Bibliográficos
Autores principales: Li, Shanglin, Zhao, Ruocong, Zheng, Diwei, Qin, Le, Cui, Yuanbin, Li, Yao, Jiang, Zhiwu, Zhong, Mengjun, Shi, Jingxuan, Li, Ming, Wang, Xindong, Tang, Zhaoyang, Wu, Qiting, Long, Youguo, Hu, Duo, Wang, Suna, Yao, Yao, Liu, Shuang, Yang, Li-Hua, Zhang, Zhenfeng, Tang, Qiannan, Liu, Pentao, Li, Yangqiu, Li, Peng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9218287/
https://www.ncbi.nlm.nih.gov/pubmed/35784403
http://dx.doi.org/10.1016/j.omto.2022.06.003

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