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Clioquinol as an inhibitor of JmjC-histone demethylase exhibits common and unique histone methylome and transcriptome between clioquinol and hypoxia

Clioquinol (CQ) is a hypoxic mimicker to activate hypoxia-inducible factor-1α (HIF-1α) by inhibiting HIF-1α specific asparaginyl hypoxylase (FIH-1). The structural similarity of the Jumonji C (JmjC) domain between FIH-1 and JmjC domain-containing histone lysine demethylases (JmjC-KDMs) led us to inv...

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Detalles Bibliográficos
Autores principales:	Moon, Yunwon, Chae, Sehyun, Yim, Sujin, Yang, Eun Gyeong, Choe, Jungwoo, Hyun, Jiyeon, Chang, Rakwoo, Hwang, Daehee, Park, Hyunsung
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9218365/ https://www.ncbi.nlm.nih.gov/pubmed/35754713 http://dx.doi.org/10.1016/j.isci.2022.104517

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