Cargando…
Progesterone limits the tumor-promoting effects of the beta-subunit of human chorionic gonadotropin via non-nuclear receptors
The post-menopausal state in women is associated with increased cancer incidence, the reasons for which remain obscure. Curiously, increased circulating levels of beta-hCG (human chorionic gonadotropin) (a hormonal subunit linked with tumors of several lineages) are also often observed post-menopaus...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9218381/ https://www.ncbi.nlm.nih.gov/pubmed/35754725 http://dx.doi.org/10.1016/j.isci.2022.104527 |
_version_ | 1784731874969518080 |
---|---|
author | Sarkar, Moumita Sharma, Harsh Singh, Parminder Ranu, Ranbala Sharma, Ravi Datta Agrawal, Usha Pal, Rahul |
author_facet | Sarkar, Moumita Sharma, Harsh Singh, Parminder Ranu, Ranbala Sharma, Ravi Datta Agrawal, Usha Pal, Rahul |
author_sort | Sarkar, Moumita |
collection | PubMed |
description | The post-menopausal state in women is associated with increased cancer incidence, the reasons for which remain obscure. Curiously, increased circulating levels of beta-hCG (human chorionic gonadotropin) (a hormonal subunit linked with tumors of several lineages) are also often observed post-menopause. This study describes a previously unidentified interplay between beta-hCG and progesterone in tumorigenesis. Progesterone mediated apoptosis in beta-hCG responsive tumor cells via non-nuclear receptors. The transgenic expression of beta-hCG, particularly in the absence of the ovaries (a mimic of the post-menopausal state) constituted a potent pro-tumorigenic signal. Significantly, the administration of progesterone had significant anti-tumor effects. RNA-seq profiling identified molecular signatures associated with these processes. TCGA analysis revealed correlates between the expression of several newly identified genes and poor prognosis in post-menopausal patients of lung adenocarcinoma, colon adenocarcinoma, and glioblastoma. Specifically in these women, the detection of intra-tumoral/extra-tumoral beta-hCG may serve as a useful prognostic indicator, and treatment with progesterone on its detection may prove beneficial. |
format | Online Article Text |
id | pubmed-9218381 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-92183812022-06-24 Progesterone limits the tumor-promoting effects of the beta-subunit of human chorionic gonadotropin via non-nuclear receptors Sarkar, Moumita Sharma, Harsh Singh, Parminder Ranu, Ranbala Sharma, Ravi Datta Agrawal, Usha Pal, Rahul iScience Article The post-menopausal state in women is associated with increased cancer incidence, the reasons for which remain obscure. Curiously, increased circulating levels of beta-hCG (human chorionic gonadotropin) (a hormonal subunit linked with tumors of several lineages) are also often observed post-menopause. This study describes a previously unidentified interplay between beta-hCG and progesterone in tumorigenesis. Progesterone mediated apoptosis in beta-hCG responsive tumor cells via non-nuclear receptors. The transgenic expression of beta-hCG, particularly in the absence of the ovaries (a mimic of the post-menopausal state) constituted a potent pro-tumorigenic signal. Significantly, the administration of progesterone had significant anti-tumor effects. RNA-seq profiling identified molecular signatures associated with these processes. TCGA analysis revealed correlates between the expression of several newly identified genes and poor prognosis in post-menopausal patients of lung adenocarcinoma, colon adenocarcinoma, and glioblastoma. Specifically in these women, the detection of intra-tumoral/extra-tumoral beta-hCG may serve as a useful prognostic indicator, and treatment with progesterone on its detection may prove beneficial. Elsevier 2022-06-03 /pmc/articles/PMC9218381/ /pubmed/35754725 http://dx.doi.org/10.1016/j.isci.2022.104527 Text en © 2022 The Author(s) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Article Sarkar, Moumita Sharma, Harsh Singh, Parminder Ranu, Ranbala Sharma, Ravi Datta Agrawal, Usha Pal, Rahul Progesterone limits the tumor-promoting effects of the beta-subunit of human chorionic gonadotropin via non-nuclear receptors |
title | Progesterone limits the tumor-promoting effects of the beta-subunit of human chorionic gonadotropin via non-nuclear receptors |
title_full | Progesterone limits the tumor-promoting effects of the beta-subunit of human chorionic gonadotropin via non-nuclear receptors |
title_fullStr | Progesterone limits the tumor-promoting effects of the beta-subunit of human chorionic gonadotropin via non-nuclear receptors |
title_full_unstemmed | Progesterone limits the tumor-promoting effects of the beta-subunit of human chorionic gonadotropin via non-nuclear receptors |
title_short | Progesterone limits the tumor-promoting effects of the beta-subunit of human chorionic gonadotropin via non-nuclear receptors |
title_sort | progesterone limits the tumor-promoting effects of the beta-subunit of human chorionic gonadotropin via non-nuclear receptors |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9218381/ https://www.ncbi.nlm.nih.gov/pubmed/35754725 http://dx.doi.org/10.1016/j.isci.2022.104527 |
work_keys_str_mv | AT sarkarmoumita progesteronelimitsthetumorpromotingeffectsofthebetasubunitofhumanchorionicgonadotropinvianonnuclearreceptors AT sharmaharsh progesteronelimitsthetumorpromotingeffectsofthebetasubunitofhumanchorionicgonadotropinvianonnuclearreceptors AT singhparminder progesteronelimitsthetumorpromotingeffectsofthebetasubunitofhumanchorionicgonadotropinvianonnuclearreceptors AT ranuranbala progesteronelimitsthetumorpromotingeffectsofthebetasubunitofhumanchorionicgonadotropinvianonnuclearreceptors AT sharmaravidatta progesteronelimitsthetumorpromotingeffectsofthebetasubunitofhumanchorionicgonadotropinvianonnuclearreceptors AT agrawalusha progesteronelimitsthetumorpromotingeffectsofthebetasubunitofhumanchorionicgonadotropinvianonnuclearreceptors AT palrahul progesteronelimitsthetumorpromotingeffectsofthebetasubunitofhumanchorionicgonadotropinvianonnuclearreceptors |