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Prediction of the generalization of myasthenia gravis with purely ocular symptoms at onset: a multivariable model development and validation

BACKGROUND: About half of myasthenia gravis (MG) patients with purely ocular symptoms at onset progress to generalized myasthenia gravis (gMG). OBJECTIVES: To develop and validate a model to predict the generalization of MG at 6 months after disease onset in patients with ocular-onset myasthenia gra...

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Autores principales: Li, Feng, Zhang, Hongbin, Tao, Ya, Stascheit, Frauke, Han, Jiaojiao, Gao, Feng, Liu, Hongbo, Carmona-Bayonas, Alberto, Li, Zhongmin, Rueckert, Jens-C., Meisel, Andreas, Zhao, Song
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9218496/
https://www.ncbi.nlm.nih.gov/pubmed/35755967
http://dx.doi.org/10.1177/17562864221104508
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author Li, Feng
Zhang, Hongbin
Tao, Ya
Stascheit, Frauke
Han, Jiaojiao
Gao, Feng
Liu, Hongbo
Carmona-Bayonas, Alberto
Li, Zhongmin
Rueckert, Jens-C.
Meisel, Andreas
Zhao, Song
author_facet Li, Feng
Zhang, Hongbin
Tao, Ya
Stascheit, Frauke
Han, Jiaojiao
Gao, Feng
Liu, Hongbo
Carmona-Bayonas, Alberto
Li, Zhongmin
Rueckert, Jens-C.
Meisel, Andreas
Zhao, Song
author_sort Li, Feng
collection PubMed
description BACKGROUND: About half of myasthenia gravis (MG) patients with purely ocular symptoms at onset progress to generalized myasthenia gravis (gMG). OBJECTIVES: To develop and validate a model to predict the generalization of MG at 6 months after disease onset in patients with ocular-onset myasthenia gravis (OoMG). METHODS: Data of patients with OoMG were retrospectively collected from two tertiary hospitals in Germany and China. An accelerated failure time model was developed using the backward elimination method based on the German cohort to predict the generalization of OoMG. The model was then externally validated in the Chinese cohort, and its performance was assessed using Harrell’s C-index and calibration plots. RESULTS: Four hundred and seventy-seven patients (275 from Germany and 202 from China) were eligible for inclusion. One hundred and three (37.5%) patients in the German cohort progressed from OoMG to gMG with a median follow-up time of 69 (32–116) months. The median time to generalization was 29 (16–71) months. The estimated cumulative probability of generalization was 30.5% [95% CI (confidence interval), 24.3–36.2%) at 5 years after disease onset. The final model, which was represented as a nomogram, included five clinical variables: sex, titer of anti-AChR antibody, status of anti-MuSK antibody, age at disease onset and the presence of other autoimmune disease. External validation of the model using the bootstrap showed a C-index of 0.670 (95% CI, 0.602–0.738). Calibration curves revealed moderate agreement of predicted and observed outcomes. CONCLUSION: The nomogram is a good predictor for generalization in patients with OoMG that can be used to inform of the individual generalization risk, which might improve the clinical decision-making.
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spelling pubmed-92184962022-06-24 Prediction of the generalization of myasthenia gravis with purely ocular symptoms at onset: a multivariable model development and validation Li, Feng Zhang, Hongbin Tao, Ya Stascheit, Frauke Han, Jiaojiao Gao, Feng Liu, Hongbo Carmona-Bayonas, Alberto Li, Zhongmin Rueckert, Jens-C. Meisel, Andreas Zhao, Song Ther Adv Neurol Disord Original Research BACKGROUND: About half of myasthenia gravis (MG) patients with purely ocular symptoms at onset progress to generalized myasthenia gravis (gMG). OBJECTIVES: To develop and validate a model to predict the generalization of MG at 6 months after disease onset in patients with ocular-onset myasthenia gravis (OoMG). METHODS: Data of patients with OoMG were retrospectively collected from two tertiary hospitals in Germany and China. An accelerated failure time model was developed using the backward elimination method based on the German cohort to predict the generalization of OoMG. The model was then externally validated in the Chinese cohort, and its performance was assessed using Harrell’s C-index and calibration plots. RESULTS: Four hundred and seventy-seven patients (275 from Germany and 202 from China) were eligible for inclusion. One hundred and three (37.5%) patients in the German cohort progressed from OoMG to gMG with a median follow-up time of 69 (32–116) months. The median time to generalization was 29 (16–71) months. The estimated cumulative probability of generalization was 30.5% [95% CI (confidence interval), 24.3–36.2%) at 5 years after disease onset. The final model, which was represented as a nomogram, included five clinical variables: sex, titer of anti-AChR antibody, status of anti-MuSK antibody, age at disease onset and the presence of other autoimmune disease. External validation of the model using the bootstrap showed a C-index of 0.670 (95% CI, 0.602–0.738). Calibration curves revealed moderate agreement of predicted and observed outcomes. CONCLUSION: The nomogram is a good predictor for generalization in patients with OoMG that can be used to inform of the individual generalization risk, which might improve the clinical decision-making. SAGE Publications 2022-06-21 /pmc/articles/PMC9218496/ /pubmed/35755967 http://dx.doi.org/10.1177/17562864221104508 Text en © The Author(s), 2022 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Original Research
Li, Feng
Zhang, Hongbin
Tao, Ya
Stascheit, Frauke
Han, Jiaojiao
Gao, Feng
Liu, Hongbo
Carmona-Bayonas, Alberto
Li, Zhongmin
Rueckert, Jens-C.
Meisel, Andreas
Zhao, Song
Prediction of the generalization of myasthenia gravis with purely ocular symptoms at onset: a multivariable model development and validation
title Prediction of the generalization of myasthenia gravis with purely ocular symptoms at onset: a multivariable model development and validation
title_full Prediction of the generalization of myasthenia gravis with purely ocular symptoms at onset: a multivariable model development and validation
title_fullStr Prediction of the generalization of myasthenia gravis with purely ocular symptoms at onset: a multivariable model development and validation
title_full_unstemmed Prediction of the generalization of myasthenia gravis with purely ocular symptoms at onset: a multivariable model development and validation
title_short Prediction of the generalization of myasthenia gravis with purely ocular symptoms at onset: a multivariable model development and validation
title_sort prediction of the generalization of myasthenia gravis with purely ocular symptoms at onset: a multivariable model development and validation
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9218496/
https://www.ncbi.nlm.nih.gov/pubmed/35755967
http://dx.doi.org/10.1177/17562864221104508
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