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Unmet Medical Needs in Chronic, Non-communicable Inflammatory Skin Diseases

An estimated 20–25% of the population is affected by chronic, non-communicable inflammatory skin diseases. Chronic skin inflammation has many causes. Among the most frequent chronic inflammatory skin diseases are atopic dermatitis, psoriasis, urticaria, lichen planus, and hidradenitis suppurativa, d...

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Autores principales: Ujiie, Hideyuki, Rosmarin, David, Schön, Michael P., Ständer, Sonja, Boch, Katharina, Metz, Martin, Maurer, Marcus, Thaci, Diamant, Schmidt, Enno, Cole, Connor, Amber, Kyle T., Didona, Dario, Hertl, Michael, Recke, Andreas, Graßhoff, Hanna, Hackel, Alexander, Schumann, Anja, Riemekasten, Gabriela, Bieber, Katja, Sprow, Gant, Dan, Joshua, Zillikens, Detlef, Sezin, Tanya, Christiano, Angela M., Wolk, Kerstin, Sabat, Robert, Kridin, Khalaf, Werth, Victoria P., Ludwig, Ralf J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9218547/
https://www.ncbi.nlm.nih.gov/pubmed/35755063
http://dx.doi.org/10.3389/fmed.2022.875492
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author Ujiie, Hideyuki
Rosmarin, David
Schön, Michael P.
Ständer, Sonja
Boch, Katharina
Metz, Martin
Maurer, Marcus
Thaci, Diamant
Schmidt, Enno
Cole, Connor
Amber, Kyle T.
Didona, Dario
Hertl, Michael
Recke, Andreas
Graßhoff, Hanna
Hackel, Alexander
Schumann, Anja
Riemekasten, Gabriela
Bieber, Katja
Sprow, Gant
Dan, Joshua
Zillikens, Detlef
Sezin, Tanya
Christiano, Angela M.
Wolk, Kerstin
Sabat, Robert
Kridin, Khalaf
Werth, Victoria P.
Ludwig, Ralf J.
author_facet Ujiie, Hideyuki
Rosmarin, David
Schön, Michael P.
Ständer, Sonja
Boch, Katharina
Metz, Martin
Maurer, Marcus
Thaci, Diamant
Schmidt, Enno
Cole, Connor
Amber, Kyle T.
Didona, Dario
Hertl, Michael
Recke, Andreas
Graßhoff, Hanna
Hackel, Alexander
Schumann, Anja
Riemekasten, Gabriela
Bieber, Katja
Sprow, Gant
Dan, Joshua
Zillikens, Detlef
Sezin, Tanya
Christiano, Angela M.
Wolk, Kerstin
Sabat, Robert
Kridin, Khalaf
Werth, Victoria P.
Ludwig, Ralf J.
author_sort Ujiie, Hideyuki
collection PubMed
description An estimated 20–25% of the population is affected by chronic, non-communicable inflammatory skin diseases. Chronic skin inflammation has many causes. Among the most frequent chronic inflammatory skin diseases are atopic dermatitis, psoriasis, urticaria, lichen planus, and hidradenitis suppurativa, driven by a complex interplay of genetics and environmental factors. Autoimmunity is another important cause of chronic skin inflammation. The autoimmune response may be mainly T cell driven, such as in alopecia areata or vitiligo, or B cell driven in chronic spontaneous urticaria, pemphigus and pemphigoid diseases. Rare causes of chronic skin inflammation are autoinflammatory diseases, or rheumatic diseases, such as cutaneous lupus erythematosus or dermatomyositis. Whilst we have seen a significant improvement in diagnosis and treatment, several challenges remain. Especially for rarer causes of chronic skin inflammation, early diagnosis is often missed because of low awareness and lack of diagnostics. Systemic immunosuppression is the treatment of choice for almost all of these diseases. Adverse events due to immunosuppression, insufficient therapeutic responses and relapses remain a challenge. For atopic dermatitis and psoriasis, a broad spectrum of innovative treatments has been developed. However, treatment responses cannot be predicted so far. Hence, development of (bio)markers allowing selection of specific medications for individual patients is needed. Given the encouraging developments during the past years, we envision that many of these challenges in the diagnosis and treatment of chronic inflammatory skin diseases will be thoroughly addressed in the future.
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spelling pubmed-92185472022-06-24 Unmet Medical Needs in Chronic, Non-communicable Inflammatory Skin Diseases Ujiie, Hideyuki Rosmarin, David Schön, Michael P. Ständer, Sonja Boch, Katharina Metz, Martin Maurer, Marcus Thaci, Diamant Schmidt, Enno Cole, Connor Amber, Kyle T. Didona, Dario Hertl, Michael Recke, Andreas Graßhoff, Hanna Hackel, Alexander Schumann, Anja Riemekasten, Gabriela Bieber, Katja Sprow, Gant Dan, Joshua Zillikens, Detlef Sezin, Tanya Christiano, Angela M. Wolk, Kerstin Sabat, Robert Kridin, Khalaf Werth, Victoria P. Ludwig, Ralf J. Front Med (Lausanne) Medicine An estimated 20–25% of the population is affected by chronic, non-communicable inflammatory skin diseases. Chronic skin inflammation has many causes. Among the most frequent chronic inflammatory skin diseases are atopic dermatitis, psoriasis, urticaria, lichen planus, and hidradenitis suppurativa, driven by a complex interplay of genetics and environmental factors. Autoimmunity is another important cause of chronic skin inflammation. The autoimmune response may be mainly T cell driven, such as in alopecia areata or vitiligo, or B cell driven in chronic spontaneous urticaria, pemphigus and pemphigoid diseases. Rare causes of chronic skin inflammation are autoinflammatory diseases, or rheumatic diseases, such as cutaneous lupus erythematosus or dermatomyositis. Whilst we have seen a significant improvement in diagnosis and treatment, several challenges remain. Especially for rarer causes of chronic skin inflammation, early diagnosis is often missed because of low awareness and lack of diagnostics. Systemic immunosuppression is the treatment of choice for almost all of these diseases. Adverse events due to immunosuppression, insufficient therapeutic responses and relapses remain a challenge. For atopic dermatitis and psoriasis, a broad spectrum of innovative treatments has been developed. However, treatment responses cannot be predicted so far. Hence, development of (bio)markers allowing selection of specific medications for individual patients is needed. Given the encouraging developments during the past years, we envision that many of these challenges in the diagnosis and treatment of chronic inflammatory skin diseases will be thoroughly addressed in the future. Frontiers Media S.A. 2022-06-09 /pmc/articles/PMC9218547/ /pubmed/35755063 http://dx.doi.org/10.3389/fmed.2022.875492 Text en Copyright © 2022 Ujiie, Rosmarin, Schön, Ständer, Boch, Metz, Maurer, Thaci, Schmidt, Cole, Amber, Didona, Hertl, Recke, Graßhoff, Hackel, Schumann, Riemekasten, Bieber, Sprow, Dan, Zillikens, Sezin, Christiano, Wolk, Sabat, Kridin, Werth and Ludwig. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Medicine
Ujiie, Hideyuki
Rosmarin, David
Schön, Michael P.
Ständer, Sonja
Boch, Katharina
Metz, Martin
Maurer, Marcus
Thaci, Diamant
Schmidt, Enno
Cole, Connor
Amber, Kyle T.
Didona, Dario
Hertl, Michael
Recke, Andreas
Graßhoff, Hanna
Hackel, Alexander
Schumann, Anja
Riemekasten, Gabriela
Bieber, Katja
Sprow, Gant
Dan, Joshua
Zillikens, Detlef
Sezin, Tanya
Christiano, Angela M.
Wolk, Kerstin
Sabat, Robert
Kridin, Khalaf
Werth, Victoria P.
Ludwig, Ralf J.
Unmet Medical Needs in Chronic, Non-communicable Inflammatory Skin Diseases
title Unmet Medical Needs in Chronic, Non-communicable Inflammatory Skin Diseases
title_full Unmet Medical Needs in Chronic, Non-communicable Inflammatory Skin Diseases
title_fullStr Unmet Medical Needs in Chronic, Non-communicable Inflammatory Skin Diseases
title_full_unstemmed Unmet Medical Needs in Chronic, Non-communicable Inflammatory Skin Diseases
title_short Unmet Medical Needs in Chronic, Non-communicable Inflammatory Skin Diseases
title_sort unmet medical needs in chronic, non-communicable inflammatory skin diseases
topic Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9218547/
https://www.ncbi.nlm.nih.gov/pubmed/35755063
http://dx.doi.org/10.3389/fmed.2022.875492
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