Hepatic SIRT6 Modulates Transcriptional Activities of FXR to Alleviate Acetaminophen-induced Hepatotoxicity

BACKGROUND & AIMS: Excessive acetaminophen (APAP) intake causes oxidative stress and inflammation, leading to fatal hepatotoxicity; however, the mechanism remains unclear. This study aims to explore the protective effects and detailed mechanisms of sirtuin 6 (SIRT6) in the defense against APAP-i...

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Detalles Bibliográficos
Autores principales: Liu, Changhui, Pan, Zhisen, Wu, Zhouli, Tang, Kaijia, Zhong, Yadi, Chen, Yingjian, Xiao, Xiaoxia, Guo, Jingyi, Duan, Siwei, Cui, Tianqi, Zhong, Guangcheng, Yang, Zifeng, Zhong, Chong, Lin, Sheng, Gao, Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9218579/
https://www.ncbi.nlm.nih.gov/pubmed/35526796
http://dx.doi.org/10.1016/j.jcmgh.2022.04.011

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