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Genetic Variability of Incretin Receptors and Alcohol Dependence: A Pilot Study

Alcohol dependence is a chronic mental disorder that leads to decreased quality of life for patients and their relatives and presents a considerable burden to society. Incretin hormones, such as glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide 1 (GLP-1) are endogenous gut...

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Autores principales: Tsermpini, Evangelia Eirini, Goričar, Katja, Kores Plesničar, Blanka, Plemenitaš Ilješ, Anja, Dolžan, Vita
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9218814/
https://www.ncbi.nlm.nih.gov/pubmed/35754710
http://dx.doi.org/10.3389/fnmol.2022.908948
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author Tsermpini, Evangelia Eirini
Goričar, Katja
Kores Plesničar, Blanka
Plemenitaš Ilješ, Anja
Dolžan, Vita
author_facet Tsermpini, Evangelia Eirini
Goričar, Katja
Kores Plesničar, Blanka
Plemenitaš Ilješ, Anja
Dolžan, Vita
author_sort Tsermpini, Evangelia Eirini
collection PubMed
description Alcohol dependence is a chronic mental disorder that leads to decreased quality of life for patients and their relatives and presents a considerable burden to society. Incretin hormones, such as glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide 1 (GLP-1) are endogenous gut-brain peptides, which can travel across the blood-brain barrier and access the nervous system. Their respective receptors, GIPR and GLP-1R, are expressed in the reward-related brain areas and are involved in memory formation and neurogenesis, which results in behavioral changes in rodent models. The current study investigated the potential association of genetic variability of incretin receptors with alcohol dependence and alcohol-related psychosymptomatology. Alcohol dependence and comorbid psychosymptomatology were assessed in a cohort of Slovenian male participants, comprised of 89 hospitalized alcohol-dependent patients, 98 abstinent alcohol-dependent patients, and 93 healthy blood donors. All participants were genotyped for GIPR rs1800437 and GLP1R rs10305420 and rs6923761 polymorphisms. For the statistical analysis Kruskal–Wall and Mann–Whitney tests were used in additive and dominant genetic models. Our findings indicated that GIPR rs1800437 genotypes were associated with an increased risk of alcohol dependence. Statistically significant association between GIPR rs1800437 GG genotype and Brief Social Phobia Scale scores were observed in the abstinent alcohol-dependent patients, while GLP1R rs6923761 GG genotype was associated with Zung anxiety scores in healthy controls. Our pilot study indicates that GIPR rs1800437 may play some role in susceptibility to alcohol dependence, as well as in alcohol-related psychosymptomatology symptoms. To our knowledge, this is the first study that indicates the involvement of GIPR in alcohol dependence. However, studies with larger cohorts are needed to confirm these preliminary findings.
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spelling pubmed-92188142022-06-24 Genetic Variability of Incretin Receptors and Alcohol Dependence: A Pilot Study Tsermpini, Evangelia Eirini Goričar, Katja Kores Plesničar, Blanka Plemenitaš Ilješ, Anja Dolžan, Vita Front Mol Neurosci Neuroscience Alcohol dependence is a chronic mental disorder that leads to decreased quality of life for patients and their relatives and presents a considerable burden to society. Incretin hormones, such as glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide 1 (GLP-1) are endogenous gut-brain peptides, which can travel across the blood-brain barrier and access the nervous system. Their respective receptors, GIPR and GLP-1R, are expressed in the reward-related brain areas and are involved in memory formation and neurogenesis, which results in behavioral changes in rodent models. The current study investigated the potential association of genetic variability of incretin receptors with alcohol dependence and alcohol-related psychosymptomatology. Alcohol dependence and comorbid psychosymptomatology were assessed in a cohort of Slovenian male participants, comprised of 89 hospitalized alcohol-dependent patients, 98 abstinent alcohol-dependent patients, and 93 healthy blood donors. All participants were genotyped for GIPR rs1800437 and GLP1R rs10305420 and rs6923761 polymorphisms. For the statistical analysis Kruskal–Wall and Mann–Whitney tests were used in additive and dominant genetic models. Our findings indicated that GIPR rs1800437 genotypes were associated with an increased risk of alcohol dependence. Statistically significant association between GIPR rs1800437 GG genotype and Brief Social Phobia Scale scores were observed in the abstinent alcohol-dependent patients, while GLP1R rs6923761 GG genotype was associated with Zung anxiety scores in healthy controls. Our pilot study indicates that GIPR rs1800437 may play some role in susceptibility to alcohol dependence, as well as in alcohol-related psychosymptomatology symptoms. To our knowledge, this is the first study that indicates the involvement of GIPR in alcohol dependence. However, studies with larger cohorts are needed to confirm these preliminary findings. Frontiers Media S.A. 2022-06-09 /pmc/articles/PMC9218814/ /pubmed/35754710 http://dx.doi.org/10.3389/fnmol.2022.908948 Text en Copyright © 2022 Tsermpini, Goričar, Kores Plesničar, Plemenitaš Ilješ and Dolžan. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Tsermpini, Evangelia Eirini
Goričar, Katja
Kores Plesničar, Blanka
Plemenitaš Ilješ, Anja
Dolžan, Vita
Genetic Variability of Incretin Receptors and Alcohol Dependence: A Pilot Study
title Genetic Variability of Incretin Receptors and Alcohol Dependence: A Pilot Study
title_full Genetic Variability of Incretin Receptors and Alcohol Dependence: A Pilot Study
title_fullStr Genetic Variability of Incretin Receptors and Alcohol Dependence: A Pilot Study
title_full_unstemmed Genetic Variability of Incretin Receptors and Alcohol Dependence: A Pilot Study
title_short Genetic Variability of Incretin Receptors and Alcohol Dependence: A Pilot Study
title_sort genetic variability of incretin receptors and alcohol dependence: a pilot study
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9218814/
https://www.ncbi.nlm.nih.gov/pubmed/35754710
http://dx.doi.org/10.3389/fnmol.2022.908948
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