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Molecular targeted therapies for pediatric atypical teratoid/rhabdoid tumors
Atypical teratoid/rhabdoid tumors (AT/RTs) are lethal central nervous system tumors, which are primarily diagnosed in infants. Current treatments for AT/RTs include surgery, radiotherapy, and chemotherapy; these treatments have poor prognoses and challenging side effects. The pivotal genetic event i...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9218972/ https://www.ncbi.nlm.nih.gov/pubmed/35774526 http://dx.doi.org/10.1002/ped4.12325 |
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author | Zhang, Chang Li, Hao |
author_facet | Zhang, Chang Li, Hao |
author_sort | Zhang, Chang |
collection | PubMed |
description | Atypical teratoid/rhabdoid tumors (AT/RTs) are lethal central nervous system tumors, which are primarily diagnosed in infants. Current treatments for AT/RTs include surgery, radiotherapy, and chemotherapy; these treatments have poor prognoses and challenging side effects. The pivotal genetic event in AT/RT pathogenesis comprises the inactivation of SMARCB1 or SMARCA4. Recent epigenetic studies have demonstrated mutual and subtype‐specific epigenetic derangements that drive tumorigenesis; the exploitation of these potential targets might improve the dismal treatment outcomes of AT/RTs. This review aims to summarize the literature concerning targeted molecular therapies for pediatric AT/RTs. |
format | Online Article Text |
id | pubmed-9218972 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-92189722022-06-29 Molecular targeted therapies for pediatric atypical teratoid/rhabdoid tumors Zhang, Chang Li, Hao Pediatr Investig Review Atypical teratoid/rhabdoid tumors (AT/RTs) are lethal central nervous system tumors, which are primarily diagnosed in infants. Current treatments for AT/RTs include surgery, radiotherapy, and chemotherapy; these treatments have poor prognoses and challenging side effects. The pivotal genetic event in AT/RT pathogenesis comprises the inactivation of SMARCB1 or SMARCA4. Recent epigenetic studies have demonstrated mutual and subtype‐specific epigenetic derangements that drive tumorigenesis; the exploitation of these potential targets might improve the dismal treatment outcomes of AT/RTs. This review aims to summarize the literature concerning targeted molecular therapies for pediatric AT/RTs. John Wiley and Sons Inc. 2022-05-23 /pmc/articles/PMC9218972/ /pubmed/35774526 http://dx.doi.org/10.1002/ped4.12325 Text en © 2022 Chinese Medical Association. Pediatric Investigation published by John Wiley & Sons Australia, Ltd on behalf of Futang Research Center of Pediatric Development. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Review Zhang, Chang Li, Hao Molecular targeted therapies for pediatric atypical teratoid/rhabdoid tumors |
title | Molecular targeted therapies for pediatric atypical teratoid/rhabdoid tumors |
title_full | Molecular targeted therapies for pediatric atypical teratoid/rhabdoid tumors |
title_fullStr | Molecular targeted therapies for pediatric atypical teratoid/rhabdoid tumors |
title_full_unstemmed | Molecular targeted therapies for pediatric atypical teratoid/rhabdoid tumors |
title_short | Molecular targeted therapies for pediatric atypical teratoid/rhabdoid tumors |
title_sort | molecular targeted therapies for pediatric atypical teratoid/rhabdoid tumors |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9218972/ https://www.ncbi.nlm.nih.gov/pubmed/35774526 http://dx.doi.org/10.1002/ped4.12325 |
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