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Acetyl-CoA metabolism drives epigenome change and contributes to carcinogenesis risk in fatty liver disease
BACKGROUND: The incidence of non-alcoholic fatty liver disease (NAFLD)-associated hepatocellular carcinoma (HCC) is increasing worldwide, but the steps in precancerous hepatocytes which lead to HCC driver mutations are not well understood. Here we provide evidence that metabolically driven histone h...
Autores principales: | , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9219160/ https://www.ncbi.nlm.nih.gov/pubmed/35739588 http://dx.doi.org/10.1186/s13073-022-01071-5 |