Acetyl-CoA metabolism drives epigenome change and contributes to carcinogenesis risk in fatty liver disease

BACKGROUND: The incidence of non-alcoholic fatty liver disease (NAFLD)-associated hepatocellular carcinoma (HCC) is increasing worldwide, but the steps in precancerous hepatocytes which lead to HCC driver mutations are not well understood. Here we provide evidence that metabolically driven histone h...

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Detalles Bibliográficos
Autores principales: Assante, Gabriella, Chandrasekaran, Sriram, Ng, Stanley, Tourna, Aikaterini, Chung, Carolina H., Isse, Kowsar A., Banks, Jasmine L., Soffientini, Ugo, Filippi, Celine, Dhawan, Anil, Liu, Mo, Rozen, Steven G., Hoare, Matthew, Campbell, Peter, Ballard, J. William O., Turner, Nigel, Morris, Margaret J., Chokshi, Shilpa, Youngson, Neil A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9219160/
https://www.ncbi.nlm.nih.gov/pubmed/35739588
http://dx.doi.org/10.1186/s13073-022-01071-5

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