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Pathological and neurophysiological outcomes of seeding human-derived tau pathology in the APP-KI NL-G-F and NL-NL mouse models of Alzheimer’s Disease

The two main histopathological hallmarks that characterize Alzheimer’s Disease are the presence of amyloid plaques and neurofibrillary tangles. One of the current approaches to studying the consequences of amyloid pathology relies on the usage of transgenic animal models that incorporate the mutant...

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Detalles Bibliográficos
Autores principales: Tok, S., Maurin, H., Delay, C., Crauwels, D., Manyakov, N. V., Van Der Elst, W., Moechars, D., Drinkenburg, W. H. I. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9219251/
https://www.ncbi.nlm.nih.gov/pubmed/35739575
http://dx.doi.org/10.1186/s40478-022-01393-w