Genome-Wide Association Study of Feed Efficiency Related Traits in Ducks

SIMPLE SUMMARY: Good feed efficiency (FE) is an important trait to ensure the economic output of the livestock and poultry industries. Herein, a genome-wide association study was conducted to identify potential variants and genes associated with seven FE measures in ducks. Genomic DNA samples of 308 ducks were collected and sequenced. All animals were evaluated concerning body weight gain (BWG), feed intake (FI), residual feed intake (RFI), feed conversion ratio (FCR), and weight at 21 (BW21) and 42 days of age (BW42). Overall, 4 (FCR), 3 (FI), 36 (RFI), 6 (BWG), 8 (BW21), and 10 (BW42) single nucleotide polymorphisms (SNPs) were significantly associated with these FE traits, respectively. Moreover, candidate genes close to the identified variants were found to be mainly involved in key pathways and terms related to metabolism. In summary, these findings improve our understanding of poultry genetics and provide new foundations for breeding programs aimed at maximizing the economic potential of duck breeding and farming. ABSTRACT: Feed efficiency (FE) is the most important economic trait in the poultry and livestock industry. Thus, genetic improvement of FE may result in a considerable reduction of the cost and energy burdens. As genome-wide association studies (GWASs) can help identify candidate variants influencing FE, the present study aimed to analyze the phenotypic correlation and identify candidate variants of the seven FE traits in ducks. All traits were found to have significant positive correlations with varying degrees. In particular, residual feed intake presented correlation coefficients of 0.61, 0.54, and 0.13 with feed conversion ratio, and feed intake, respectively. Furthermore, data from seven FE-related GWAS revealed 4 (FCR), 3 (FI), 36 (RFI), 6 (BWG), 8 (BW21), and 10 (BW42) SNPs were significantly associated with body weight gain, feed intake, residual feed intake, feed conversion ratio, and weight at 21 and 42 days, respectively. Candidate SNPs of seven FE trait-related genes were involved in galactose metabolism, starch, propanoate metabolism, sucrose metabolism and etc. Taken together, these findings provide insight into the genetic mechanisms and genes involved in FE-related traits in ducks. However, further investigations are warranted to further validate these findings.