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HO-1 Limits the Efficacy of Vemurafenib/PLX4032 in BRAF(V600E) Mutated Melanoma Cells Adapted to Physiological Normoxia or Hypoxia

Induction of heme oxygenase 1 (HO-1) favors immune-escape in BRAF(V600) melanoma cells treated with Vemurafenib/PLX4032 under standard cell culture conditions. However, the oxygen tension under standard culture conditions (~18 kPa O(2)) is significantly higher than the physiological oxygen levels en...

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Detalles Bibliográficos
Autores principales:	Furfaro, Anna Lisa, Loi, Giulia, Ivaldo, Caterina, Passalacqua, Mario, Pietra, Gabriella, Mann, Giovanni Enrico, Nitti, Mariapaola
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9219655/ https://www.ncbi.nlm.nih.gov/pubmed/35740068 http://dx.doi.org/10.3390/antiox11061171

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