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Circulating microRNAs Suggest Networks Associated with Biological Functions in Aggressive Refractory Type 2 Celiac Disease

Despite following a gluten-free diet, which is currently the only effective therapy for celiac disease, about 5% of patients can develop serious complications, which in the case of refractory type 2 could evolve towards intestinal lymphoma. In this study, we have identified a set of 15 microRNAs in...

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Detalles Bibliográficos
Autores principales: Bianchi, Nicoletta, Doneda, Luisa, Elli, Luca, Taccioli, Cristian, Vaira, Valentina, Scricciolo, Alice, Lombardo, Vincenza, Terrazzan, Anna, Colapietro, Patrizia, Terranova, Leonardo, Bergamini, Carlo, Vecchi, Maurizio, Scaramella, Lucia, Nandi, Nicoletta, Roncoroni, Leda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9219665/
https://www.ncbi.nlm.nih.gov/pubmed/35740429
http://dx.doi.org/10.3390/biomedicines10061408
Descripción
Sumario:Despite following a gluten-free diet, which is currently the only effective therapy for celiac disease, about 5% of patients can develop serious complications, which in the case of refractory type 2 could evolve towards intestinal lymphoma. In this study, we have identified a set of 15 microRNAs in serum discriminating between the two types of refractory disease. Upregulated miR-770-5p, miR-181b-2-3p, miR-1193, and miR-1226-3p could be useful for the better stratification of patients and the monitoring of disease development, while miR-490-3p was found to be dysregulated in patients with refractory type 1. Finally, by using bioinformatic tools applied to the analysis of the targets of dysregulated microRNAs, we have completed a more precise assessment of their functions. These mainly include the pathway of response to Transforming Growth Factor β cell–cell signaling by Wnt; epigenetic regulation, especially novel networks associated with transcriptional and post-transcriptional alterations; and the well-known inflammatory profiles.