Cargando…

Allosteric Communication in the Multifunctional and Redox NQO1 Protein Studied by Cavity-Making Mutations

Allosterism is a common phenomenon in protein biochemistry that allows rapid regulation of protein stability; dynamics and function. However, the mechanisms by which allosterism occurs (by mutations or post-translational modifications (PTMs)) may be complex, particularly due to long-range propagatio...

Descripción completa

Detalles Bibliográficos
Autores principales:	Pacheco-Garcia, Juan Luis, Loginov, Dmitry S., Anoz-Carbonell, Ernesto, Vankova, Pavla, Palomino-Morales, Rogelio, Salido, Eduardo, Man, Petr, Medina, Milagros, Naganathan, Athi N., Pey, Angel L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9219786/ https://www.ncbi.nlm.nih.gov/pubmed/35740007 http://dx.doi.org/10.3390/antiox11061110

Ejemplares similares

Structural basis of the pleiotropic and specific phenotypic consequences of missense mutations in the multifunctional NAD(P)H:quinone oxidoreductase 1 and their pharmacological rescue
por: Pacheco-Garcia, Juan Luis, et al.
Publicado: (2021)

Targeting HIF-1α Function in Cancer through the Chaperone Action of NQO1: Implications of Genetic Diversity of NQO1
por: Salido, Eduardo, et al.
Publicado: (2022)

The Catalytic Cycle of the Antioxidant and Cancer-Associated Human NQO1 Enzyme: Hydride Transfer, Conformational Dynamics and Functional Cooperativity
por: Anoz-Carbonell, Ernesto, et al.
Publicado: (2020)

Loss of stability and unfolding cooperativity in hPGK1 upon gradual structural perturbation of its N-terminal domain hydrophobic core
por: Pacheco-García, Juan Luis, et al.
Publicado: (2022)

A Dynamic Core in Human NQO1 Controls the Functional and Stability Effects of Ligand Binding and Their Communication across the Enzyme Dimer
por: Vankova, Pavla, et al.
Publicado: (2019)

Naturally-Occurring Rare Mutations Cause Mild to Catastrophic Effects in the Multifunctional and Cancer-Associated NQO1 Protein
por: Pacheco-García, Juan Luis, et al.
Publicado: (2020)

Site-to-site interdomain communication may mediate different loss-of-function mechanisms in a cancer-associated NQO1 polymorphism
por: Medina-Carmona, Encarnación, et al.
Publicado: (2017)

Conformational dynamics is key to understanding loss-of-function of NQO1 cancer-associated polymorphisms and its correction by pharmacological ligands
por: Medina-Carmona, Encarnación, et al.
Publicado: (2016)

Modulation of allosteric coupling by mutations: from protein dynamics and packing to altered native ensembles and function
por: Naganathan, Athi N
Publicado: (2018)

Erratum: Conformational dynamics is key to understanding loss-of-function of NQO1 cancer-associated polymorphisms and its correction by pharmacological ligands
por: Medina-Carmona, Encarnación, et al.
Publicado: (2016)

Phosphorylation of Thr9 Affects the Folding Landscape of the N-Terminal Segment of Human AGT Enhancing Protein Aggregation of Disease-Causing Mutants
por: Neira, Jose L., et al.
Publicado: (2022)

Redox modulation of NQO1
por: Siegel, David, et al.
Publicado: (2018)

Effect of naturally-occurring mutations on the stability and function of cancer-associated NQO1: Comparison of experiments and computation
por: Pacheco-Garcia, Juan Luis, et al.
Publicado: (2022)

Cofactors and pathogens: Flavin mononucleotide and flavin adenine dinucleotide (FAD) biosynthesis by the FAD synthase from Brucella ovis
por: Moreno, Andrea, et al.
Publicado: (2021)

In silico discovery and biological validation of ligands of FAD synthase, a promising new antimicrobial target
por: Lans, Isaias, et al.
Publicado: (2020)

Mutation of Aspartate 238 in FAD Synthase Isoform 6 Increases the Specific Activity by Weakening the FAD Binding
por: Leone, Piero, et al.
Publicado: (2019)

Discovery of antimicrobial compounds targeting bacterial type FAD synthetases
por: Sebastián, María, et al.
Publicado: (2017)

The diverse functionality of NQO1 and its roles in redox control
por: Ross, David, et al.
Publicado: (2021)

NQO1-Dependent Redox Cycling of Idebenone: Effects on Cellular Redox Potential and Energy Levels
por: Haefeli, Roman H., et al.
Publicado: (2011)

A Disorder-Induced Domino-Like Destabilization Mechanism Governs the Folding and Functional Dynamics of the Repeat Protein IκBα
por: Sivanandan, Srinivasan, et al.
Publicado: (2013)

Tuning the Continuum of Structural States in the Native Ensemble of a Regulatory Protein
por: Narayan, Abhishek, et al.
Publicado: (2017)

A hierarchy of coupling free energies underlie the thermodynamic and functional architecture of protein structures
por: Naganathan, Athi N., et al.
Publicado: (2021)

Ensemble origins and distance-dependence of long-range mutational effects in proteins
por: Kannan, Adithi, et al.
Publicado: (2022)

Thermodynamic architecture and conformational plasticity of GPCRs
por: Anantakrishnan, Sathvik, et al.
Publicado: (2023)

Phenotypic Modulation of Cancer-Associated Antioxidant NQO1 Activity by Post-Translational Modifications and the Natural Diversity of the Human Genome
por: Pey, Angel L.
Publicado: (2023)

Entropic Control of an Excited Folded-Like Conformation in a Disordered Protein Ensemble
por: Munshi, Sneha, et al.
Publicado: (2018)

Thermodynamics and folding landscapes of large proteins from a statistical mechanical model
por: Gopi, Soundhararajan, et al.
Publicado: (2019)

Redox-Switchable Allosteric Effects in Molecular Clusters
por: Mitchell, Benjamin S., et al.
Publicado: (2021)

A redox-mediated conformational change in NQO1 controls binding to microtubules and α-tubulin acetylation
por: Siegel, David, et al.
Publicado: (2020)

Redox state and the sirtuin deacetylases are major factors that regulate the acetylation status of the stress protein NQO1
por: Siegel, David, et al.
Publicado: (2022)

A binding cooperativity switch driven by synergistic structural swelling of an osmo-regulatory protein pair
por: Narayan, Abhishek, et al.
Publicado: (2019)

NAD(P)H quinone oxidoreductase (NQO1): an enzyme which needs just enough mobility, in just the right places
por: Pey, Angel L., et al.
Publicado: (2019)

Mitochondrial Function in Human Neuroblastoma Cells Is Up-Regulated and Protected by NQO1, a Plasma Membrane Redox Enzyme
por: Kim, Jiyeong, et al.
Publicado: (2013)

Docosahexanoic acid signals through the Nrf2–Nqo1 pathway to maintain redox balance and promote neurite outgrowth
por: Drolet, Jennifer, et al.
Publicado: (2021)

A polymorphism in NAD(P)H:quinone oxidoreductase (NQO1): relationship of a homozygous mutation at position 609 of the NQO1 cDNA to NQO1 activity.
por: Ross, D., et al.
Publicado: (1996)

pPerturb: A Server for Predicting Long-Distance Energetic Couplings and Mutation-Induced Stability Changes in Proteins via Perturbations
por: Gopi, Soundhararajan, et al.
Publicado: (2020)

Functional regulation of an intrinsically disordered protein via a conformationally excited state
por: Madhurima, Kulkarni, et al.
Publicado: (2023)

Implications of NQO1 in cancer therapy
por: Oh, Eun-Taex, et al.
Publicado: (2015)

The Role of NQO1 in Ovarian Cancer
por: Tossetta, Giovanni, et al.
Publicado: (2023)

Integrated allosteric regulation in the S. cerevisiae carbamylphosphate synthetase – aspartate transcarbamylase multifunctional protein
por: Serre, Valérie, et al.
Publicado: (2004)

Cannot write session to /tmp/vufind_sessions/sess_ovpt9ep9ug75t69os8ikj5jr31