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Insight of Melatonin: The Potential of Melatonin to Treat Bacteria-Induced Mastitis
Bovine mastitis is a common inflammatory disease, mainly induced by bacterial pathogens, such as Staphylococcus aureus, Escherichia coli, and Streptococcus agalactiae. Mastitis has negative effects on the production and quality of milk, resulting in huge economic losses. Melatonin, which is synthesi...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9219804/ https://www.ncbi.nlm.nih.gov/pubmed/35740004 http://dx.doi.org/10.3390/antiox11061107 |
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author | Li, Hongyang Sun, Peng |
author_facet | Li, Hongyang Sun, Peng |
author_sort | Li, Hongyang |
collection | PubMed |
description | Bovine mastitis is a common inflammatory disease, mainly induced by bacterial pathogens, such as Staphylococcus aureus, Escherichia coli, and Streptococcus agalactiae. Mastitis has negative effects on the production and quality of milk, resulting in huge economic losses. Melatonin, which is synthesized and secreted by the pineal gland and other organs, is ubiquitous throughout nature and has different effects on different tissues. Melatonin is crucial in modulating oxidative stress, immune responses, and cell autophagy and apoptosis, via receptor-mediated or receptor-independent signaling pathways. The potent antioxidative and anti-inflammatory activities of melatonin and its metabolites suggest that melatonin can be used to treat various infections. This article reviews the potential for melatonin to alleviate bovine mastitis through its pleiotropic effect on reducing oxidative stress, inhibiting pro-inflammatory cytokines, and regulating the activation of NF-κB, STATs, and their cascade reactions. Therefore, it is promising that melatonin supplementation may be an alternative to antibiotics for the treatment of bovine mastitis. |
format | Online Article Text |
id | pubmed-9219804 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-92198042022-06-24 Insight of Melatonin: The Potential of Melatonin to Treat Bacteria-Induced Mastitis Li, Hongyang Sun, Peng Antioxidants (Basel) Review Bovine mastitis is a common inflammatory disease, mainly induced by bacterial pathogens, such as Staphylococcus aureus, Escherichia coli, and Streptococcus agalactiae. Mastitis has negative effects on the production and quality of milk, resulting in huge economic losses. Melatonin, which is synthesized and secreted by the pineal gland and other organs, is ubiquitous throughout nature and has different effects on different tissues. Melatonin is crucial in modulating oxidative stress, immune responses, and cell autophagy and apoptosis, via receptor-mediated or receptor-independent signaling pathways. The potent antioxidative and anti-inflammatory activities of melatonin and its metabolites suggest that melatonin can be used to treat various infections. This article reviews the potential for melatonin to alleviate bovine mastitis through its pleiotropic effect on reducing oxidative stress, inhibiting pro-inflammatory cytokines, and regulating the activation of NF-κB, STATs, and their cascade reactions. Therefore, it is promising that melatonin supplementation may be an alternative to antibiotics for the treatment of bovine mastitis. MDPI 2022-06-02 /pmc/articles/PMC9219804/ /pubmed/35740004 http://dx.doi.org/10.3390/antiox11061107 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Li, Hongyang Sun, Peng Insight of Melatonin: The Potential of Melatonin to Treat Bacteria-Induced Mastitis |
title | Insight of Melatonin: The Potential of Melatonin to Treat Bacteria-Induced Mastitis |
title_full | Insight of Melatonin: The Potential of Melatonin to Treat Bacteria-Induced Mastitis |
title_fullStr | Insight of Melatonin: The Potential of Melatonin to Treat Bacteria-Induced Mastitis |
title_full_unstemmed | Insight of Melatonin: The Potential of Melatonin to Treat Bacteria-Induced Mastitis |
title_short | Insight of Melatonin: The Potential of Melatonin to Treat Bacteria-Induced Mastitis |
title_sort | insight of melatonin: the potential of melatonin to treat bacteria-induced mastitis |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9219804/ https://www.ncbi.nlm.nih.gov/pubmed/35740004 http://dx.doi.org/10.3390/antiox11061107 |
work_keys_str_mv | AT lihongyang insightofmelatoninthepotentialofmelatonintotreatbacteriainducedmastitis AT sunpeng insightofmelatoninthepotentialofmelatonintotreatbacteriainducedmastitis |