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Insight of Melatonin: The Potential of Melatonin to Treat Bacteria-Induced Mastitis

Bovine mastitis is a common inflammatory disease, mainly induced by bacterial pathogens, such as Staphylococcus aureus, Escherichia coli, and Streptococcus agalactiae. Mastitis has negative effects on the production and quality of milk, resulting in huge economic losses. Melatonin, which is synthesi...

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Detalles Bibliográficos
Autores principales: Li, Hongyang, Sun, Peng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9219804/
https://www.ncbi.nlm.nih.gov/pubmed/35740004
http://dx.doi.org/10.3390/antiox11061107
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author Li, Hongyang
Sun, Peng
author_facet Li, Hongyang
Sun, Peng
author_sort Li, Hongyang
collection PubMed
description Bovine mastitis is a common inflammatory disease, mainly induced by bacterial pathogens, such as Staphylococcus aureus, Escherichia coli, and Streptococcus agalactiae. Mastitis has negative effects on the production and quality of milk, resulting in huge economic losses. Melatonin, which is synthesized and secreted by the pineal gland and other organs, is ubiquitous throughout nature and has different effects on different tissues. Melatonin is crucial in modulating oxidative stress, immune responses, and cell autophagy and apoptosis, via receptor-mediated or receptor-independent signaling pathways. The potent antioxidative and anti-inflammatory activities of melatonin and its metabolites suggest that melatonin can be used to treat various infections. This article reviews the potential for melatonin to alleviate bovine mastitis through its pleiotropic effect on reducing oxidative stress, inhibiting pro-inflammatory cytokines, and regulating the activation of NF-κB, STATs, and their cascade reactions. Therefore, it is promising that melatonin supplementation may be an alternative to antibiotics for the treatment of bovine mastitis.
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spelling pubmed-92198042022-06-24 Insight of Melatonin: The Potential of Melatonin to Treat Bacteria-Induced Mastitis Li, Hongyang Sun, Peng Antioxidants (Basel) Review Bovine mastitis is a common inflammatory disease, mainly induced by bacterial pathogens, such as Staphylococcus aureus, Escherichia coli, and Streptococcus agalactiae. Mastitis has negative effects on the production and quality of milk, resulting in huge economic losses. Melatonin, which is synthesized and secreted by the pineal gland and other organs, is ubiquitous throughout nature and has different effects on different tissues. Melatonin is crucial in modulating oxidative stress, immune responses, and cell autophagy and apoptosis, via receptor-mediated or receptor-independent signaling pathways. The potent antioxidative and anti-inflammatory activities of melatonin and its metabolites suggest that melatonin can be used to treat various infections. This article reviews the potential for melatonin to alleviate bovine mastitis through its pleiotropic effect on reducing oxidative stress, inhibiting pro-inflammatory cytokines, and regulating the activation of NF-κB, STATs, and their cascade reactions. Therefore, it is promising that melatonin supplementation may be an alternative to antibiotics for the treatment of bovine mastitis. MDPI 2022-06-02 /pmc/articles/PMC9219804/ /pubmed/35740004 http://dx.doi.org/10.3390/antiox11061107 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Li, Hongyang
Sun, Peng
Insight of Melatonin: The Potential of Melatonin to Treat Bacteria-Induced Mastitis
title Insight of Melatonin: The Potential of Melatonin to Treat Bacteria-Induced Mastitis
title_full Insight of Melatonin: The Potential of Melatonin to Treat Bacteria-Induced Mastitis
title_fullStr Insight of Melatonin: The Potential of Melatonin to Treat Bacteria-Induced Mastitis
title_full_unstemmed Insight of Melatonin: The Potential of Melatonin to Treat Bacteria-Induced Mastitis
title_short Insight of Melatonin: The Potential of Melatonin to Treat Bacteria-Induced Mastitis
title_sort insight of melatonin: the potential of melatonin to treat bacteria-induced mastitis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9219804/
https://www.ncbi.nlm.nih.gov/pubmed/35740004
http://dx.doi.org/10.3390/antiox11061107
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