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CT-Detected MTA Score Related to Disability and Behavior in Older People with Cognitive Impairment
Our study aims to investigate the relationship between medial temporal lobe atrophy (MTA) score, assessed by computed tomography (CT) scans, and functional impairment, cognitive deficit, and psycho-behavioral disorder severity. Overall, 239 (M = 92, F = 147; mean age of 79.3 ± 6.8 years) patients we...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9219852/ https://www.ncbi.nlm.nih.gov/pubmed/35740403 http://dx.doi.org/10.3390/biomedicines10061381 |
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author | Lauriola, Michele D’Onofrio, Grazia la Torre, Annamaria Ciccone, Filomena Germano, Carmela Cascavilla, Leandro Greco, Antonio |
author_facet | Lauriola, Michele D’Onofrio, Grazia la Torre, Annamaria Ciccone, Filomena Germano, Carmela Cascavilla, Leandro Greco, Antonio |
author_sort | Lauriola, Michele |
collection | PubMed |
description | Our study aims to investigate the relationship between medial temporal lobe atrophy (MTA) score, assessed by computed tomography (CT) scans, and functional impairment, cognitive deficit, and psycho-behavioral disorder severity. Overall, 239 (M = 92, F = 147; mean age of 79.3 ± 6.8 years) patients were evaluated with cognitive, neuropsychiatric, affective, and functional assessment scales. MTA was evaluated from 0 (no atrophy) to 4 (severe atrophy). The homocysteine serum was set to two levels: between 0 and 10 µmol/L, and >10 µmol/L. The cholesterol and glycemia blood concentrations were measured. Hypertension and atrial fibrillation presence/absence were collected. A total of 14 patients were MTA 0, 44 patients were MTA 1, 63 patients were MTA 2, 79 patients were MTA 3, and 39 patients were MTA 4. Cognitive (p < 0.0001) and functional (p < 0.0001) parameters decreased according to the MTA severity. According to the diagnosis distribution, AD patient percentages increased by MTA severity (p < 0.0001). In addition, the homocysteine levels increased according to MTA severity (p < 0.0001). Depression (p < 0.0001) and anxiety (p = 0.001) increased according to MTA severity. This study encourages and supports the potential role of MTA score and CT scan in the field of neurodegenerative disorder research and diagnosis. |
format | Online Article Text |
id | pubmed-9219852 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-92198522022-06-24 CT-Detected MTA Score Related to Disability and Behavior in Older People with Cognitive Impairment Lauriola, Michele D’Onofrio, Grazia la Torre, Annamaria Ciccone, Filomena Germano, Carmela Cascavilla, Leandro Greco, Antonio Biomedicines Article Our study aims to investigate the relationship between medial temporal lobe atrophy (MTA) score, assessed by computed tomography (CT) scans, and functional impairment, cognitive deficit, and psycho-behavioral disorder severity. Overall, 239 (M = 92, F = 147; mean age of 79.3 ± 6.8 years) patients were evaluated with cognitive, neuropsychiatric, affective, and functional assessment scales. MTA was evaluated from 0 (no atrophy) to 4 (severe atrophy). The homocysteine serum was set to two levels: between 0 and 10 µmol/L, and >10 µmol/L. The cholesterol and glycemia blood concentrations were measured. Hypertension and atrial fibrillation presence/absence were collected. A total of 14 patients were MTA 0, 44 patients were MTA 1, 63 patients were MTA 2, 79 patients were MTA 3, and 39 patients were MTA 4. Cognitive (p < 0.0001) and functional (p < 0.0001) parameters decreased according to the MTA severity. According to the diagnosis distribution, AD patient percentages increased by MTA severity (p < 0.0001). In addition, the homocysteine levels increased according to MTA severity (p < 0.0001). Depression (p < 0.0001) and anxiety (p = 0.001) increased according to MTA severity. This study encourages and supports the potential role of MTA score and CT scan in the field of neurodegenerative disorder research and diagnosis. MDPI 2022-06-10 /pmc/articles/PMC9219852/ /pubmed/35740403 http://dx.doi.org/10.3390/biomedicines10061381 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Lauriola, Michele D’Onofrio, Grazia la Torre, Annamaria Ciccone, Filomena Germano, Carmela Cascavilla, Leandro Greco, Antonio CT-Detected MTA Score Related to Disability and Behavior in Older People with Cognitive Impairment |
title | CT-Detected MTA Score Related to Disability and Behavior in Older People with Cognitive Impairment |
title_full | CT-Detected MTA Score Related to Disability and Behavior in Older People with Cognitive Impairment |
title_fullStr | CT-Detected MTA Score Related to Disability and Behavior in Older People with Cognitive Impairment |
title_full_unstemmed | CT-Detected MTA Score Related to Disability and Behavior in Older People with Cognitive Impairment |
title_short | CT-Detected MTA Score Related to Disability and Behavior in Older People with Cognitive Impairment |
title_sort | ct-detected mta score related to disability and behavior in older people with cognitive impairment |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9219852/ https://www.ncbi.nlm.nih.gov/pubmed/35740403 http://dx.doi.org/10.3390/biomedicines10061381 |
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