Cargando…

CT-Detected MTA Score Related to Disability and Behavior in Older People with Cognitive Impairment

Our study aims to investigate the relationship between medial temporal lobe atrophy (MTA) score, assessed by computed tomography (CT) scans, and functional impairment, cognitive deficit, and psycho-behavioral disorder severity. Overall, 239 (M = 92, F = 147; mean age of 79.3 ± 6.8 years) patients we...

Descripción completa

Detalles Bibliográficos
Autores principales: Lauriola, Michele, D’Onofrio, Grazia, la Torre, Annamaria, Ciccone, Filomena, Germano, Carmela, Cascavilla, Leandro, Greco, Antonio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9219852/
https://www.ncbi.nlm.nih.gov/pubmed/35740403
http://dx.doi.org/10.3390/biomedicines10061381
_version_ 1784732223419711488
author Lauriola, Michele
D’Onofrio, Grazia
la Torre, Annamaria
Ciccone, Filomena
Germano, Carmela
Cascavilla, Leandro
Greco, Antonio
author_facet Lauriola, Michele
D’Onofrio, Grazia
la Torre, Annamaria
Ciccone, Filomena
Germano, Carmela
Cascavilla, Leandro
Greco, Antonio
author_sort Lauriola, Michele
collection PubMed
description Our study aims to investigate the relationship between medial temporal lobe atrophy (MTA) score, assessed by computed tomography (CT) scans, and functional impairment, cognitive deficit, and psycho-behavioral disorder severity. Overall, 239 (M = 92, F = 147; mean age of 79.3 ± 6.8 years) patients were evaluated with cognitive, neuropsychiatric, affective, and functional assessment scales. MTA was evaluated from 0 (no atrophy) to 4 (severe atrophy). The homocysteine serum was set to two levels: between 0 and 10 µmol/L, and >10 µmol/L. The cholesterol and glycemia blood concentrations were measured. Hypertension and atrial fibrillation presence/absence were collected. A total of 14 patients were MTA 0, 44 patients were MTA 1, 63 patients were MTA 2, 79 patients were MTA 3, and 39 patients were MTA 4. Cognitive (p < 0.0001) and functional (p < 0.0001) parameters decreased according to the MTA severity. According to the diagnosis distribution, AD patient percentages increased by MTA severity (p < 0.0001). In addition, the homocysteine levels increased according to MTA severity (p < 0.0001). Depression (p < 0.0001) and anxiety (p = 0.001) increased according to MTA severity. This study encourages and supports the potential role of MTA score and CT scan in the field of neurodegenerative disorder research and diagnosis.
format Online
Article
Text
id pubmed-9219852
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-92198522022-06-24 CT-Detected MTA Score Related to Disability and Behavior in Older People with Cognitive Impairment Lauriola, Michele D’Onofrio, Grazia la Torre, Annamaria Ciccone, Filomena Germano, Carmela Cascavilla, Leandro Greco, Antonio Biomedicines Article Our study aims to investigate the relationship between medial temporal lobe atrophy (MTA) score, assessed by computed tomography (CT) scans, and functional impairment, cognitive deficit, and psycho-behavioral disorder severity. Overall, 239 (M = 92, F = 147; mean age of 79.3 ± 6.8 years) patients were evaluated with cognitive, neuropsychiatric, affective, and functional assessment scales. MTA was evaluated from 0 (no atrophy) to 4 (severe atrophy). The homocysteine serum was set to two levels: between 0 and 10 µmol/L, and >10 µmol/L. The cholesterol and glycemia blood concentrations were measured. Hypertension and atrial fibrillation presence/absence were collected. A total of 14 patients were MTA 0, 44 patients were MTA 1, 63 patients were MTA 2, 79 patients were MTA 3, and 39 patients were MTA 4. Cognitive (p < 0.0001) and functional (p < 0.0001) parameters decreased according to the MTA severity. According to the diagnosis distribution, AD patient percentages increased by MTA severity (p < 0.0001). In addition, the homocysteine levels increased according to MTA severity (p < 0.0001). Depression (p < 0.0001) and anxiety (p = 0.001) increased according to MTA severity. This study encourages and supports the potential role of MTA score and CT scan in the field of neurodegenerative disorder research and diagnosis. MDPI 2022-06-10 /pmc/articles/PMC9219852/ /pubmed/35740403 http://dx.doi.org/10.3390/biomedicines10061381 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Lauriola, Michele
D’Onofrio, Grazia
la Torre, Annamaria
Ciccone, Filomena
Germano, Carmela
Cascavilla, Leandro
Greco, Antonio
CT-Detected MTA Score Related to Disability and Behavior in Older People with Cognitive Impairment
title CT-Detected MTA Score Related to Disability and Behavior in Older People with Cognitive Impairment
title_full CT-Detected MTA Score Related to Disability and Behavior in Older People with Cognitive Impairment
title_fullStr CT-Detected MTA Score Related to Disability and Behavior in Older People with Cognitive Impairment
title_full_unstemmed CT-Detected MTA Score Related to Disability and Behavior in Older People with Cognitive Impairment
title_short CT-Detected MTA Score Related to Disability and Behavior in Older People with Cognitive Impairment
title_sort ct-detected mta score related to disability and behavior in older people with cognitive impairment
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9219852/
https://www.ncbi.nlm.nih.gov/pubmed/35740403
http://dx.doi.org/10.3390/biomedicines10061381
work_keys_str_mv AT lauriolamichele ctdetectedmtascorerelatedtodisabilityandbehaviorinolderpeoplewithcognitiveimpairment
AT donofriograzia ctdetectedmtascorerelatedtodisabilityandbehaviorinolderpeoplewithcognitiveimpairment
AT latorreannamaria ctdetectedmtascorerelatedtodisabilityandbehaviorinolderpeoplewithcognitiveimpairment
AT cicconefilomena ctdetectedmtascorerelatedtodisabilityandbehaviorinolderpeoplewithcognitiveimpairment
AT germanocarmela ctdetectedmtascorerelatedtodisabilityandbehaviorinolderpeoplewithcognitiveimpairment
AT cascavillaleandro ctdetectedmtascorerelatedtodisabilityandbehaviorinolderpeoplewithcognitiveimpairment
AT grecoantonio ctdetectedmtascorerelatedtodisabilityandbehaviorinolderpeoplewithcognitiveimpairment