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Screening of the Supercritical Impregnation of Olea europaea Leaves Extract into Filaments of Thermoplastic Polyurethane (TPU) and Polylactic Acid (PLA) Intended for Biomedical Applications

The leaves of Olea europaea as agricultural waste represent a convenient source of antioxidants. In combination with supercritical CO(2) (scCO(2)), assisted impregnation is an interesting strategy for the preparation of biomedical devices with specific bioactivity. For this purpose, 3D-printable fil...

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Autores principales: Machado, Noelia D., Cejudo-Bastante, Cristina, Goñi, María L., Gañán, Nicolás A., Casas-Cardoso, Lourdes, Mantell-Serrano, Casimiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9219857/
https://www.ncbi.nlm.nih.gov/pubmed/35740066
http://dx.doi.org/10.3390/antiox11061170
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author Machado, Noelia D.
Cejudo-Bastante, Cristina
Goñi, María L.
Gañán, Nicolás A.
Casas-Cardoso, Lourdes
Mantell-Serrano, Casimiro
author_facet Machado, Noelia D.
Cejudo-Bastante, Cristina
Goñi, María L.
Gañán, Nicolás A.
Casas-Cardoso, Lourdes
Mantell-Serrano, Casimiro
author_sort Machado, Noelia D.
collection PubMed
description The leaves of Olea europaea as agricultural waste represent a convenient source of antioxidants. In combination with supercritical CO(2) (scCO(2)), assisted impregnation is an interesting strategy for the preparation of biomedical devices with specific bioactivity. For this purpose, 3D-printable filaments of thermoplastic polyurethane (TPU) and polylactic acid (PLA) were employed for the supercritical impregnation of ethanolic olive leaves extract (OLE) for biomedical application. The extraction of OLE was performed using pressurized liquids. The effect of pressure (100–400 bar), temperature (35–55 °C), and the polymer type on the OLE impregnation and the swelling degree were studied including a morphological analysis and the measurement of the final antioxidant activity. All the studied variables as well as their interactions showed significant effects on the OLE loading. Higher temperatures favored the OLE loading while the pressure presented opposite effects at values higher than 250 bar. Thus, the highest OLE loadings were achieved at 250 bar and 55 °C for both polymers. However, TPU showed c.a. 4 times higher OLE loading and antioxidant activity in comparison with PLA at the optimal conditions. To the best of our knowledge, this is the first report using TPU for the supercritical impregnation of a natural extract with bioactivity.
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spelling pubmed-92198572022-06-24 Screening of the Supercritical Impregnation of Olea europaea Leaves Extract into Filaments of Thermoplastic Polyurethane (TPU) and Polylactic Acid (PLA) Intended for Biomedical Applications Machado, Noelia D. Cejudo-Bastante, Cristina Goñi, María L. Gañán, Nicolás A. Casas-Cardoso, Lourdes Mantell-Serrano, Casimiro Antioxidants (Basel) Article The leaves of Olea europaea as agricultural waste represent a convenient source of antioxidants. In combination with supercritical CO(2) (scCO(2)), assisted impregnation is an interesting strategy for the preparation of biomedical devices with specific bioactivity. For this purpose, 3D-printable filaments of thermoplastic polyurethane (TPU) and polylactic acid (PLA) were employed for the supercritical impregnation of ethanolic olive leaves extract (OLE) for biomedical application. The extraction of OLE was performed using pressurized liquids. The effect of pressure (100–400 bar), temperature (35–55 °C), and the polymer type on the OLE impregnation and the swelling degree were studied including a morphological analysis and the measurement of the final antioxidant activity. All the studied variables as well as their interactions showed significant effects on the OLE loading. Higher temperatures favored the OLE loading while the pressure presented opposite effects at values higher than 250 bar. Thus, the highest OLE loadings were achieved at 250 bar and 55 °C for both polymers. However, TPU showed c.a. 4 times higher OLE loading and antioxidant activity in comparison with PLA at the optimal conditions. To the best of our knowledge, this is the first report using TPU for the supercritical impregnation of a natural extract with bioactivity. MDPI 2022-06-14 /pmc/articles/PMC9219857/ /pubmed/35740066 http://dx.doi.org/10.3390/antiox11061170 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Machado, Noelia D.
Cejudo-Bastante, Cristina
Goñi, María L.
Gañán, Nicolás A.
Casas-Cardoso, Lourdes
Mantell-Serrano, Casimiro
Screening of the Supercritical Impregnation of Olea europaea Leaves Extract into Filaments of Thermoplastic Polyurethane (TPU) and Polylactic Acid (PLA) Intended for Biomedical Applications
title Screening of the Supercritical Impregnation of Olea europaea Leaves Extract into Filaments of Thermoplastic Polyurethane (TPU) and Polylactic Acid (PLA) Intended for Biomedical Applications
title_full Screening of the Supercritical Impregnation of Olea europaea Leaves Extract into Filaments of Thermoplastic Polyurethane (TPU) and Polylactic Acid (PLA) Intended for Biomedical Applications
title_fullStr Screening of the Supercritical Impregnation of Olea europaea Leaves Extract into Filaments of Thermoplastic Polyurethane (TPU) and Polylactic Acid (PLA) Intended for Biomedical Applications
title_full_unstemmed Screening of the Supercritical Impregnation of Olea europaea Leaves Extract into Filaments of Thermoplastic Polyurethane (TPU) and Polylactic Acid (PLA) Intended for Biomedical Applications
title_short Screening of the Supercritical Impregnation of Olea europaea Leaves Extract into Filaments of Thermoplastic Polyurethane (TPU) and Polylactic Acid (PLA) Intended for Biomedical Applications
title_sort screening of the supercritical impregnation of olea europaea leaves extract into filaments of thermoplastic polyurethane (tpu) and polylactic acid (pla) intended for biomedical applications
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9219857/
https://www.ncbi.nlm.nih.gov/pubmed/35740066
http://dx.doi.org/10.3390/antiox11061170
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