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Polyphenols and IUGR Pregnancies: Effects of the Antioxidant Hydroxytyrosol on the Hippocampus Proteome in a Porcine Model

Supplementation of a mother’s diet with antioxidants such as hydroxytyrosol (HTX) has been proposed to ameliorate the adverse phenotypes of foetuses affected by intrauterine growth restriction (IUGR). Our previous studies showed, in a porcine model of IUGR, an effect of maternal HTX supplementation...

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Autores principales: Yeste, Natalia, Pérez-Valle, Jorge, Vázquez-Gómez, Marta, García-Contreras, Consolación, González-Bulnes, Antonio, Bassols, Anna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9219860/
https://www.ncbi.nlm.nih.gov/pubmed/35740029
http://dx.doi.org/10.3390/antiox11061135
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author Yeste, Natalia
Pérez-Valle, Jorge
Vázquez-Gómez, Marta
García-Contreras, Consolación
González-Bulnes, Antonio
Bassols, Anna
author_facet Yeste, Natalia
Pérez-Valle, Jorge
Vázquez-Gómez, Marta
García-Contreras, Consolación
González-Bulnes, Antonio
Bassols, Anna
author_sort Yeste, Natalia
collection PubMed
description Supplementation of a mother’s diet with antioxidants such as hydroxytyrosol (HTX) has been proposed to ameliorate the adverse phenotypes of foetuses affected by intrauterine growth restriction (IUGR). Our previous studies showed, in a porcine model of IUGR, an effect of maternal HTX supplementation on the neurotransmitter profile of several brain areas and the morphology of the hippocampus in 100 days old foetuses. The present study analyzed the impact of maternal HTX supplementation on the hippocampus proteome at this foetal age by TMT10plex labelling. Eleven differentially abundant proteins were identified by comparing both conditions, and eight of them downregulated and three upregulated in the HTX-treated group. The downregulated proteins were mainly involved in protein synthesis and RNA metabolism and may explain the differences in neuron differentiation in the HTX-treated group. The upregulated proteins were related to cell detoxification and could represent a potential mechanism to explain the neuroprotective effect of HTX.
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spelling pubmed-92198602022-06-24 Polyphenols and IUGR Pregnancies: Effects of the Antioxidant Hydroxytyrosol on the Hippocampus Proteome in a Porcine Model Yeste, Natalia Pérez-Valle, Jorge Vázquez-Gómez, Marta García-Contreras, Consolación González-Bulnes, Antonio Bassols, Anna Antioxidants (Basel) Communication Supplementation of a mother’s diet with antioxidants such as hydroxytyrosol (HTX) has been proposed to ameliorate the adverse phenotypes of foetuses affected by intrauterine growth restriction (IUGR). Our previous studies showed, in a porcine model of IUGR, an effect of maternal HTX supplementation on the neurotransmitter profile of several brain areas and the morphology of the hippocampus in 100 days old foetuses. The present study analyzed the impact of maternal HTX supplementation on the hippocampus proteome at this foetal age by TMT10plex labelling. Eleven differentially abundant proteins were identified by comparing both conditions, and eight of them downregulated and three upregulated in the HTX-treated group. The downregulated proteins were mainly involved in protein synthesis and RNA metabolism and may explain the differences in neuron differentiation in the HTX-treated group. The upregulated proteins were related to cell detoxification and could represent a potential mechanism to explain the neuroprotective effect of HTX. MDPI 2022-06-09 /pmc/articles/PMC9219860/ /pubmed/35740029 http://dx.doi.org/10.3390/antiox11061135 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Yeste, Natalia
Pérez-Valle, Jorge
Vázquez-Gómez, Marta
García-Contreras, Consolación
González-Bulnes, Antonio
Bassols, Anna
Polyphenols and IUGR Pregnancies: Effects of the Antioxidant Hydroxytyrosol on the Hippocampus Proteome in a Porcine Model
title Polyphenols and IUGR Pregnancies: Effects of the Antioxidant Hydroxytyrosol on the Hippocampus Proteome in a Porcine Model
title_full Polyphenols and IUGR Pregnancies: Effects of the Antioxidant Hydroxytyrosol on the Hippocampus Proteome in a Porcine Model
title_fullStr Polyphenols and IUGR Pregnancies: Effects of the Antioxidant Hydroxytyrosol on the Hippocampus Proteome in a Porcine Model
title_full_unstemmed Polyphenols and IUGR Pregnancies: Effects of the Antioxidant Hydroxytyrosol on the Hippocampus Proteome in a Porcine Model
title_short Polyphenols and IUGR Pregnancies: Effects of the Antioxidant Hydroxytyrosol on the Hippocampus Proteome in a Porcine Model
title_sort polyphenols and iugr pregnancies: effects of the antioxidant hydroxytyrosol on the hippocampus proteome in a porcine model
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9219860/
https://www.ncbi.nlm.nih.gov/pubmed/35740029
http://dx.doi.org/10.3390/antiox11061135
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