Current Developments of N-Heterocyclic Carbene Au(I)/Au(III) Complexes toward Cancer Treatment

Since their first discovery, N-heterocyclic carbenes have had a significant impact on organometallic chemistry. Due to their nature as strong σ-donor and π-acceptor ligands, they are exceptionally well suited to stabilize Au(I) and Au(III) complexes in biological environments. Over the last decade,...

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Detalles Bibliográficos
Autores principales: Tialiou, Alexia, Chin, Jiamin, Keppler, Bernhard K., Reithofer, Michael R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9219884/
https://www.ncbi.nlm.nih.gov/pubmed/35740438
http://dx.doi.org/10.3390/biomedicines10061417
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author Tialiou, Alexia
Chin, Jiamin
Keppler, Bernhard K.
Reithofer, Michael R.
author_facet Tialiou, Alexia
Chin, Jiamin
Keppler, Bernhard K.
Reithofer, Michael R.
author_sort Tialiou, Alexia
collection PubMed
description Since their first discovery, N-heterocyclic carbenes have had a significant impact on organometallic chemistry. Due to their nature as strong σ-donor and π-acceptor ligands, they are exceptionally well suited to stabilize Au(I) and Au(III) complexes in biological environments. Over the last decade, the development of rationally designed NHCAu(I/III) complexes to specifically target DNA has led to a new “gold rush” in bioinorganic chemistry. This review aims to summarize the latest advances of NHCAu(I/III) complexes that are able to interact with DNA. Furthermore, the latest advancements on acyclic diamino carbene gold complexes with anticancer activity are presented as these typically overlooked NHC alternatives offer great additional design possibilities in the toolbox of carbene-stabilized gold complexes for targeted therapy.
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spelling pubmed-92198842022-06-24 Current Developments of N-Heterocyclic Carbene Au(I)/Au(III) Complexes toward Cancer Treatment Tialiou, Alexia Chin, Jiamin Keppler, Bernhard K. Reithofer, Michael R. Biomedicines Review Since their first discovery, N-heterocyclic carbenes have had a significant impact on organometallic chemistry. Due to their nature as strong σ-donor and π-acceptor ligands, they are exceptionally well suited to stabilize Au(I) and Au(III) complexes in biological environments. Over the last decade, the development of rationally designed NHCAu(I/III) complexes to specifically target DNA has led to a new “gold rush” in bioinorganic chemistry. This review aims to summarize the latest advances of NHCAu(I/III) complexes that are able to interact with DNA. Furthermore, the latest advancements on acyclic diamino carbene gold complexes with anticancer activity are presented as these typically overlooked NHC alternatives offer great additional design possibilities in the toolbox of carbene-stabilized gold complexes for targeted therapy. MDPI 2022-06-15 /pmc/articles/PMC9219884/ /pubmed/35740438 http://dx.doi.org/10.3390/biomedicines10061417 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Tialiou, Alexia
Chin, Jiamin
Keppler, Bernhard K.
Reithofer, Michael R.
Current Developments of N-Heterocyclic Carbene Au(I)/Au(III) Complexes toward Cancer Treatment
title Current Developments of N-Heterocyclic Carbene Au(I)/Au(III) Complexes toward Cancer Treatment
title_full Current Developments of N-Heterocyclic Carbene Au(I)/Au(III) Complexes toward Cancer Treatment
title_fullStr Current Developments of N-Heterocyclic Carbene Au(I)/Au(III) Complexes toward Cancer Treatment
title_full_unstemmed Current Developments of N-Heterocyclic Carbene Au(I)/Au(III) Complexes toward Cancer Treatment
title_short Current Developments of N-Heterocyclic Carbene Au(I)/Au(III) Complexes toward Cancer Treatment
title_sort current developments of n-heterocyclic carbene au(i)/au(iii) complexes toward cancer treatment
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9219884/
https://www.ncbi.nlm.nih.gov/pubmed/35740438
http://dx.doi.org/10.3390/biomedicines10061417
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