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Nanostructured Antibiotics and Their Emerging Medicinal Applications: An Overview of Nanoantibiotics

Bacterial strains resistant to antimicrobial treatments, such as antibiotics, have emerged as serious clinical problems, necessitating the development of novel bactericidal materials. Nanostructures with particle sizes ranging from 1 to 100 nanometers have appeared recently as novel antibacterial ag...

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Autores principales: Modi, Shreya, Inwati, Gajendra Kumar, Gacem, Amel, Saquib Abullais, Shahabe, Prajapati, Rajendra, Yadav, Virendra Kumar, Syed, Rabbani, Alqahtani, Mohammed S., Yadav, Krishna Kumar, Islam, Saiful, Ahn, Yongtae, Jeon, Byong-Hun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9219893/
https://www.ncbi.nlm.nih.gov/pubmed/35740115
http://dx.doi.org/10.3390/antibiotics11060708
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author Modi, Shreya
Inwati, Gajendra Kumar
Gacem, Amel
Saquib Abullais, Shahabe
Prajapati, Rajendra
Yadav, Virendra Kumar
Syed, Rabbani
Alqahtani, Mohammed S.
Yadav, Krishna Kumar
Islam, Saiful
Ahn, Yongtae
Jeon, Byong-Hun
author_facet Modi, Shreya
Inwati, Gajendra Kumar
Gacem, Amel
Saquib Abullais, Shahabe
Prajapati, Rajendra
Yadav, Virendra Kumar
Syed, Rabbani
Alqahtani, Mohammed S.
Yadav, Krishna Kumar
Islam, Saiful
Ahn, Yongtae
Jeon, Byong-Hun
author_sort Modi, Shreya
collection PubMed
description Bacterial strains resistant to antimicrobial treatments, such as antibiotics, have emerged as serious clinical problems, necessitating the development of novel bactericidal materials. Nanostructures with particle sizes ranging from 1 to 100 nanometers have appeared recently as novel antibacterial agents, which are also known as “nanoantibiotics”. Nanomaterials have been shown to exert greater antibacterial effects on Gram-positive and Gram-negative bacteria across several studies. Antibacterial nanofilms for medical implants and restorative matters to prevent bacterial harm and antibacterial vaccinations to control bacterial infections are examples of nanoparticle applications in the biomedical sectors. The development of unique nanostructures, such as nanocrystals and nanostructured materials, is an exciting step in alternative efforts to manage microorganisms because these materials provide disrupted antibacterial effects, including better biocompatibility, as opposed to minor molecular antimicrobial systems, which have short-term functions and are poisonous. Although the mechanism of action of nanoparticles (NPs) is unknown, scientific suggestions include the oxidative-reductive phenomenon, reactive ionic metals, and reactive oxygen species (ROS). Many synchronized gene transformations in the same bacterial cell are essential for antibacterial resistance to emerge; thus, bacterial cells find it difficult to build resistance to nanoparticles. Therefore, nanomaterials are considered as advanced solution tools for the fields of medical science and allied health science. The current review emphasizes the importance of nanoparticles and various nanosized materials as antimicrobial agents based on their size, nature, etc.
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spelling pubmed-92198932022-06-24 Nanostructured Antibiotics and Their Emerging Medicinal Applications: An Overview of Nanoantibiotics Modi, Shreya Inwati, Gajendra Kumar Gacem, Amel Saquib Abullais, Shahabe Prajapati, Rajendra Yadav, Virendra Kumar Syed, Rabbani Alqahtani, Mohammed S. Yadav, Krishna Kumar Islam, Saiful Ahn, Yongtae Jeon, Byong-Hun Antibiotics (Basel) Review Bacterial strains resistant to antimicrobial treatments, such as antibiotics, have emerged as serious clinical problems, necessitating the development of novel bactericidal materials. Nanostructures with particle sizes ranging from 1 to 100 nanometers have appeared recently as novel antibacterial agents, which are also known as “nanoantibiotics”. Nanomaterials have been shown to exert greater antibacterial effects on Gram-positive and Gram-negative bacteria across several studies. Antibacterial nanofilms for medical implants and restorative matters to prevent bacterial harm and antibacterial vaccinations to control bacterial infections are examples of nanoparticle applications in the biomedical sectors. The development of unique nanostructures, such as nanocrystals and nanostructured materials, is an exciting step in alternative efforts to manage microorganisms because these materials provide disrupted antibacterial effects, including better biocompatibility, as opposed to minor molecular antimicrobial systems, which have short-term functions and are poisonous. Although the mechanism of action of nanoparticles (NPs) is unknown, scientific suggestions include the oxidative-reductive phenomenon, reactive ionic metals, and reactive oxygen species (ROS). Many synchronized gene transformations in the same bacterial cell are essential for antibacterial resistance to emerge; thus, bacterial cells find it difficult to build resistance to nanoparticles. Therefore, nanomaterials are considered as advanced solution tools for the fields of medical science and allied health science. The current review emphasizes the importance of nanoparticles and various nanosized materials as antimicrobial agents based on their size, nature, etc. MDPI 2022-05-25 /pmc/articles/PMC9219893/ /pubmed/35740115 http://dx.doi.org/10.3390/antibiotics11060708 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Modi, Shreya
Inwati, Gajendra Kumar
Gacem, Amel
Saquib Abullais, Shahabe
Prajapati, Rajendra
Yadav, Virendra Kumar
Syed, Rabbani
Alqahtani, Mohammed S.
Yadav, Krishna Kumar
Islam, Saiful
Ahn, Yongtae
Jeon, Byong-Hun
Nanostructured Antibiotics and Their Emerging Medicinal Applications: An Overview of Nanoantibiotics
title Nanostructured Antibiotics and Their Emerging Medicinal Applications: An Overview of Nanoantibiotics
title_full Nanostructured Antibiotics and Their Emerging Medicinal Applications: An Overview of Nanoantibiotics
title_fullStr Nanostructured Antibiotics and Their Emerging Medicinal Applications: An Overview of Nanoantibiotics
title_full_unstemmed Nanostructured Antibiotics and Their Emerging Medicinal Applications: An Overview of Nanoantibiotics
title_short Nanostructured Antibiotics and Their Emerging Medicinal Applications: An Overview of Nanoantibiotics
title_sort nanostructured antibiotics and their emerging medicinal applications: an overview of nanoantibiotics
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9219893/
https://www.ncbi.nlm.nih.gov/pubmed/35740115
http://dx.doi.org/10.3390/antibiotics11060708
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