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Treatment of Pediatric Helicobacter pylori Infection

Helicobacter pylori infection can cause gastritis, gastric or duodenal ulcers, mucosa-associated lymphoid tissue lymphoma, gastric cancer, and extra-gastrointestinal manifestations. Ideal treatment should be guided by antibiotic susceptibility testing. However, this is not feasible in many regions,...

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Detalles Bibliográficos
Autores principales: Lai, Hung-Hsiang, Lai, Ming-Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9219902/
https://www.ncbi.nlm.nih.gov/pubmed/35740162
http://dx.doi.org/10.3390/antibiotics11060757
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author Lai, Hung-Hsiang
Lai, Ming-Wei
author_facet Lai, Hung-Hsiang
Lai, Ming-Wei
author_sort Lai, Hung-Hsiang
collection PubMed
description Helicobacter pylori infection can cause gastritis, gastric or duodenal ulcers, mucosa-associated lymphoid tissue lymphoma, gastric cancer, and extra-gastrointestinal manifestations. Ideal treatment should be guided by antibiotic susceptibility testing. However, this is not feasible in many regions, so the treatment generally relies on clinical experience and regional culture sensitivity profiles. We aimed to integrate the treatment of pediatric H. pylori infection through a systematic literature review. Databases including PubMed, Cochrane Library, EMBASE, and Scholar were searched using terms containing (Helicobacter OR Helicobacter pylori OR H. pylori) AND (child OR pediatric) for all relevant manuscripts and guidelines, published from January 2011 to December 2021. The eradication rate for pediatric H. pylori infection was not satisfactory using triple therapy, sequential therapy, concomitant therapy, bismuth-based quadruple therapy, or adjuvant therapy with probiotics as the first-line therapy. Most therapies could not achieve the recommended eradication rate of >90%, which may be attributed to varying regional antibiotic resistance and possible poor children’s compliance. More studies are required to establish a best practice for pediatric H. pylori infection treatment.
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spelling pubmed-92199022022-06-24 Treatment of Pediatric Helicobacter pylori Infection Lai, Hung-Hsiang Lai, Ming-Wei Antibiotics (Basel) Review Helicobacter pylori infection can cause gastritis, gastric or duodenal ulcers, mucosa-associated lymphoid tissue lymphoma, gastric cancer, and extra-gastrointestinal manifestations. Ideal treatment should be guided by antibiotic susceptibility testing. However, this is not feasible in many regions, so the treatment generally relies on clinical experience and regional culture sensitivity profiles. We aimed to integrate the treatment of pediatric H. pylori infection through a systematic literature review. Databases including PubMed, Cochrane Library, EMBASE, and Scholar were searched using terms containing (Helicobacter OR Helicobacter pylori OR H. pylori) AND (child OR pediatric) for all relevant manuscripts and guidelines, published from January 2011 to December 2021. The eradication rate for pediatric H. pylori infection was not satisfactory using triple therapy, sequential therapy, concomitant therapy, bismuth-based quadruple therapy, or adjuvant therapy with probiotics as the first-line therapy. Most therapies could not achieve the recommended eradication rate of >90%, which may be attributed to varying regional antibiotic resistance and possible poor children’s compliance. More studies are required to establish a best practice for pediatric H. pylori infection treatment. MDPI 2022-06-01 /pmc/articles/PMC9219902/ /pubmed/35740162 http://dx.doi.org/10.3390/antibiotics11060757 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Lai, Hung-Hsiang
Lai, Ming-Wei
Treatment of Pediatric Helicobacter pylori Infection
title Treatment of Pediatric Helicobacter pylori Infection
title_full Treatment of Pediatric Helicobacter pylori Infection
title_fullStr Treatment of Pediatric Helicobacter pylori Infection
title_full_unstemmed Treatment of Pediatric Helicobacter pylori Infection
title_short Treatment of Pediatric Helicobacter pylori Infection
title_sort treatment of pediatric helicobacter pylori infection
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9219902/
https://www.ncbi.nlm.nih.gov/pubmed/35740162
http://dx.doi.org/10.3390/antibiotics11060757
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