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Impact of the COVID-19 Pandemic on Inpatient Antibiotic Consumption in Switzerland
The aim of this study was to analyze inpatient antibiotic consumption during the first 16 months of the COVID-19 pandemic in Switzerland. The entire period (January 2018–June 2021) was divided into the prepandemic period, the first and second waves, and the intermediate period. In the first year of...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9219927/ https://www.ncbi.nlm.nih.gov/pubmed/35740198 http://dx.doi.org/10.3390/antibiotics11060792 |
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author | Friedli, Olivier Gasser, Michael Cusini, Alexia Fulchini, Rosamaria Vuichard-Gysin, Danielle Halder Tobler, Roswitha Wassilew, Nasstasja Plüss-Suard, Catherine Kronenberg, Andreas |
author_facet | Friedli, Olivier Gasser, Michael Cusini, Alexia Fulchini, Rosamaria Vuichard-Gysin, Danielle Halder Tobler, Roswitha Wassilew, Nasstasja Plüss-Suard, Catherine Kronenberg, Andreas |
author_sort | Friedli, Olivier |
collection | PubMed |
description | The aim of this study was to analyze inpatient antibiotic consumption during the first 16 months of the COVID-19 pandemic in Switzerland. The entire period (January 2018–June 2021) was divided into the prepandemic period, the first and second waves, and the intermediate period. In the first year of the pandemic, total overall inpatient antibiotic consumption measured in defined daily doses (DDD) per 100 bed-days remained stable (+1.7%), with a slight increase in ICUs of +4.2%. The increase in consumption of broad-spectrum antibiotics was +12.3% overall and 17.3% in ICUs. The segmented regression model of monthly data revealed an increase in overall antibiotic consumption during the first wave but not during the second wave. In the correlation analysis performed in a subset of the data, a significant positive association was found between broad-spectrum antibiotic consumption and an increasing number of hospitalized COVID-19 patients (p = 0.018). Restricting this dataset to ICUs, we found significant positive correlations between the number of hospitalized COVID-19 patients and total antibiotic consumption (p = 0.007) and broad-spectrum antibiotic consumption (p < 0.001). In conclusion, inpatient antibiotic use during the different periods of the COVID-19 pandemic varied greatly and was predominantly notable for broad-spectrum antibiotics. |
format | Online Article Text |
id | pubmed-9219927 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-92199272022-06-24 Impact of the COVID-19 Pandemic on Inpatient Antibiotic Consumption in Switzerland Friedli, Olivier Gasser, Michael Cusini, Alexia Fulchini, Rosamaria Vuichard-Gysin, Danielle Halder Tobler, Roswitha Wassilew, Nasstasja Plüss-Suard, Catherine Kronenberg, Andreas Antibiotics (Basel) Article The aim of this study was to analyze inpatient antibiotic consumption during the first 16 months of the COVID-19 pandemic in Switzerland. The entire period (January 2018–June 2021) was divided into the prepandemic period, the first and second waves, and the intermediate period. In the first year of the pandemic, total overall inpatient antibiotic consumption measured in defined daily doses (DDD) per 100 bed-days remained stable (+1.7%), with a slight increase in ICUs of +4.2%. The increase in consumption of broad-spectrum antibiotics was +12.3% overall and 17.3% in ICUs. The segmented regression model of monthly data revealed an increase in overall antibiotic consumption during the first wave but not during the second wave. In the correlation analysis performed in a subset of the data, a significant positive association was found between broad-spectrum antibiotic consumption and an increasing number of hospitalized COVID-19 patients (p = 0.018). Restricting this dataset to ICUs, we found significant positive correlations between the number of hospitalized COVID-19 patients and total antibiotic consumption (p = 0.007) and broad-spectrum antibiotic consumption (p < 0.001). In conclusion, inpatient antibiotic use during the different periods of the COVID-19 pandemic varied greatly and was predominantly notable for broad-spectrum antibiotics. MDPI 2022-06-11 /pmc/articles/PMC9219927/ /pubmed/35740198 http://dx.doi.org/10.3390/antibiotics11060792 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Friedli, Olivier Gasser, Michael Cusini, Alexia Fulchini, Rosamaria Vuichard-Gysin, Danielle Halder Tobler, Roswitha Wassilew, Nasstasja Plüss-Suard, Catherine Kronenberg, Andreas Impact of the COVID-19 Pandemic on Inpatient Antibiotic Consumption in Switzerland |
title | Impact of the COVID-19 Pandemic on Inpatient Antibiotic Consumption in Switzerland |
title_full | Impact of the COVID-19 Pandemic on Inpatient Antibiotic Consumption in Switzerland |
title_fullStr | Impact of the COVID-19 Pandemic on Inpatient Antibiotic Consumption in Switzerland |
title_full_unstemmed | Impact of the COVID-19 Pandemic on Inpatient Antibiotic Consumption in Switzerland |
title_short | Impact of the COVID-19 Pandemic on Inpatient Antibiotic Consumption in Switzerland |
title_sort | impact of the covid-19 pandemic on inpatient antibiotic consumption in switzerland |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9219927/ https://www.ncbi.nlm.nih.gov/pubmed/35740198 http://dx.doi.org/10.3390/antibiotics11060792 |
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