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Impact of the COVID-19 Pandemic on Inpatient Antibiotic Consumption in Switzerland

The aim of this study was to analyze inpatient antibiotic consumption during the first 16 months of the COVID-19 pandemic in Switzerland. The entire period (January 2018–June 2021) was divided into the prepandemic period, the first and second waves, and the intermediate period. In the first year of...

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Autores principales: Friedli, Olivier, Gasser, Michael, Cusini, Alexia, Fulchini, Rosamaria, Vuichard-Gysin, Danielle, Halder Tobler, Roswitha, Wassilew, Nasstasja, Plüss-Suard, Catherine, Kronenberg, Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9219927/
https://www.ncbi.nlm.nih.gov/pubmed/35740198
http://dx.doi.org/10.3390/antibiotics11060792
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author Friedli, Olivier
Gasser, Michael
Cusini, Alexia
Fulchini, Rosamaria
Vuichard-Gysin, Danielle
Halder Tobler, Roswitha
Wassilew, Nasstasja
Plüss-Suard, Catherine
Kronenberg, Andreas
author_facet Friedli, Olivier
Gasser, Michael
Cusini, Alexia
Fulchini, Rosamaria
Vuichard-Gysin, Danielle
Halder Tobler, Roswitha
Wassilew, Nasstasja
Plüss-Suard, Catherine
Kronenberg, Andreas
author_sort Friedli, Olivier
collection PubMed
description The aim of this study was to analyze inpatient antibiotic consumption during the first 16 months of the COVID-19 pandemic in Switzerland. The entire period (January 2018–June 2021) was divided into the prepandemic period, the first and second waves, and the intermediate period. In the first year of the pandemic, total overall inpatient antibiotic consumption measured in defined daily doses (DDD) per 100 bed-days remained stable (+1.7%), with a slight increase in ICUs of +4.2%. The increase in consumption of broad-spectrum antibiotics was +12.3% overall and 17.3% in ICUs. The segmented regression model of monthly data revealed an increase in overall antibiotic consumption during the first wave but not during the second wave. In the correlation analysis performed in a subset of the data, a significant positive association was found between broad-spectrum antibiotic consumption and an increasing number of hospitalized COVID-19 patients (p = 0.018). Restricting this dataset to ICUs, we found significant positive correlations between the number of hospitalized COVID-19 patients and total antibiotic consumption (p = 0.007) and broad-spectrum antibiotic consumption (p < 0.001). In conclusion, inpatient antibiotic use during the different periods of the COVID-19 pandemic varied greatly and was predominantly notable for broad-spectrum antibiotics.
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spelling pubmed-92199272022-06-24 Impact of the COVID-19 Pandemic on Inpatient Antibiotic Consumption in Switzerland Friedli, Olivier Gasser, Michael Cusini, Alexia Fulchini, Rosamaria Vuichard-Gysin, Danielle Halder Tobler, Roswitha Wassilew, Nasstasja Plüss-Suard, Catherine Kronenberg, Andreas Antibiotics (Basel) Article The aim of this study was to analyze inpatient antibiotic consumption during the first 16 months of the COVID-19 pandemic in Switzerland. The entire period (January 2018–June 2021) was divided into the prepandemic period, the first and second waves, and the intermediate period. In the first year of the pandemic, total overall inpatient antibiotic consumption measured in defined daily doses (DDD) per 100 bed-days remained stable (+1.7%), with a slight increase in ICUs of +4.2%. The increase in consumption of broad-spectrum antibiotics was +12.3% overall and 17.3% in ICUs. The segmented regression model of monthly data revealed an increase in overall antibiotic consumption during the first wave but not during the second wave. In the correlation analysis performed in a subset of the data, a significant positive association was found between broad-spectrum antibiotic consumption and an increasing number of hospitalized COVID-19 patients (p = 0.018). Restricting this dataset to ICUs, we found significant positive correlations between the number of hospitalized COVID-19 patients and total antibiotic consumption (p = 0.007) and broad-spectrum antibiotic consumption (p < 0.001). In conclusion, inpatient antibiotic use during the different periods of the COVID-19 pandemic varied greatly and was predominantly notable for broad-spectrum antibiotics. MDPI 2022-06-11 /pmc/articles/PMC9219927/ /pubmed/35740198 http://dx.doi.org/10.3390/antibiotics11060792 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Friedli, Olivier
Gasser, Michael
Cusini, Alexia
Fulchini, Rosamaria
Vuichard-Gysin, Danielle
Halder Tobler, Roswitha
Wassilew, Nasstasja
Plüss-Suard, Catherine
Kronenberg, Andreas
Impact of the COVID-19 Pandemic on Inpatient Antibiotic Consumption in Switzerland
title Impact of the COVID-19 Pandemic on Inpatient Antibiotic Consumption in Switzerland
title_full Impact of the COVID-19 Pandemic on Inpatient Antibiotic Consumption in Switzerland
title_fullStr Impact of the COVID-19 Pandemic on Inpatient Antibiotic Consumption in Switzerland
title_full_unstemmed Impact of the COVID-19 Pandemic on Inpatient Antibiotic Consumption in Switzerland
title_short Impact of the COVID-19 Pandemic on Inpatient Antibiotic Consumption in Switzerland
title_sort impact of the covid-19 pandemic on inpatient antibiotic consumption in switzerland
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9219927/
https://www.ncbi.nlm.nih.gov/pubmed/35740198
http://dx.doi.org/10.3390/antibiotics11060792
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