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Persistent Coagulase-Negative Staphylococcal Bacteremia in Neonates: Clinical, Microbiological Characteristics and Changes within a Decade

Atypical outbreaks of persistent coagulase-negative staphylococci (CoNS) bacteremias, defined as three or more consecutive positive blood cultures with the same CoNS species, at least 48 h apart, have been reported in neonatal intensive-care units (NICUs). Our aim was to describe the profile of thes...

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Autores principales: Bellou, Venetia, Gkentzi, Despoina, Giormezis, Nikolaos, Vervenioti, Aggeliki, Spiliopoulou, Iris, Dimitriou, Gabriel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9219984/
https://www.ncbi.nlm.nih.gov/pubmed/35740171
http://dx.doi.org/10.3390/antibiotics11060765
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author Bellou, Venetia
Gkentzi, Despoina
Giormezis, Nikolaos
Vervenioti, Aggeliki
Spiliopoulou, Iris
Dimitriou, Gabriel
author_facet Bellou, Venetia
Gkentzi, Despoina
Giormezis, Nikolaos
Vervenioti, Aggeliki
Spiliopoulou, Iris
Dimitriou, Gabriel
author_sort Bellou, Venetia
collection PubMed
description Atypical outbreaks of persistent coagulase-negative staphylococci (CoNS) bacteremias, defined as three or more consecutive positive blood cultures with the same CoNS species, at least 48 h apart, have been reported in neonatal intensive-care units (NICUs). Our aim was to describe the profile of these cases in our NICU over a two-year period with the objective of assessing possible changes within a decade. Demographics, clinical and microbiological data were recorded for all CoNS bacteremias in our tertiary NICU during 2016–2017 and compared with the results of the same study in 2006–2007. Fifty-six cases of CoNS sepsis were recorded. Fourteen (25%) of them were persistent. There were no significant differences in demographic and clinical characteristics between cases with persistent vs. non-persistent bacteremia. Staphylococcus epidermidis was the most common species. In logistic regression analysis, biofilm production (β = 2.464, p = 0.04) was the most significant determinant for the development of persistent CoNS bacteremia. Our isolates were less likely to produce biofilm and carry ica operon as compared to those of 2006–2007. The cases of persistent CoNS sepsis have decreased within a decade, which could be attributed to the implementation of intensive infection control practices. Biofilm production remains the most important risk factor.
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spelling pubmed-92199842022-06-24 Persistent Coagulase-Negative Staphylococcal Bacteremia in Neonates: Clinical, Microbiological Characteristics and Changes within a Decade Bellou, Venetia Gkentzi, Despoina Giormezis, Nikolaos Vervenioti, Aggeliki Spiliopoulou, Iris Dimitriou, Gabriel Antibiotics (Basel) Article Atypical outbreaks of persistent coagulase-negative staphylococci (CoNS) bacteremias, defined as three or more consecutive positive blood cultures with the same CoNS species, at least 48 h apart, have been reported in neonatal intensive-care units (NICUs). Our aim was to describe the profile of these cases in our NICU over a two-year period with the objective of assessing possible changes within a decade. Demographics, clinical and microbiological data were recorded for all CoNS bacteremias in our tertiary NICU during 2016–2017 and compared with the results of the same study in 2006–2007. Fifty-six cases of CoNS sepsis were recorded. Fourteen (25%) of them were persistent. There were no significant differences in demographic and clinical characteristics between cases with persistent vs. non-persistent bacteremia. Staphylococcus epidermidis was the most common species. In logistic regression analysis, biofilm production (β = 2.464, p = 0.04) was the most significant determinant for the development of persistent CoNS bacteremia. Our isolates were less likely to produce biofilm and carry ica operon as compared to those of 2006–2007. The cases of persistent CoNS sepsis have decreased within a decade, which could be attributed to the implementation of intensive infection control practices. Biofilm production remains the most important risk factor. MDPI 2022-06-02 /pmc/articles/PMC9219984/ /pubmed/35740171 http://dx.doi.org/10.3390/antibiotics11060765 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Bellou, Venetia
Gkentzi, Despoina
Giormezis, Nikolaos
Vervenioti, Aggeliki
Spiliopoulou, Iris
Dimitriou, Gabriel
Persistent Coagulase-Negative Staphylococcal Bacteremia in Neonates: Clinical, Microbiological Characteristics and Changes within a Decade
title Persistent Coagulase-Negative Staphylococcal Bacteremia in Neonates: Clinical, Microbiological Characteristics and Changes within a Decade
title_full Persistent Coagulase-Negative Staphylococcal Bacteremia in Neonates: Clinical, Microbiological Characteristics and Changes within a Decade
title_fullStr Persistent Coagulase-Negative Staphylococcal Bacteremia in Neonates: Clinical, Microbiological Characteristics and Changes within a Decade
title_full_unstemmed Persistent Coagulase-Negative Staphylococcal Bacteremia in Neonates: Clinical, Microbiological Characteristics and Changes within a Decade
title_short Persistent Coagulase-Negative Staphylococcal Bacteremia in Neonates: Clinical, Microbiological Characteristics and Changes within a Decade
title_sort persistent coagulase-negative staphylococcal bacteremia in neonates: clinical, microbiological characteristics and changes within a decade
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9219984/
https://www.ncbi.nlm.nih.gov/pubmed/35740171
http://dx.doi.org/10.3390/antibiotics11060765
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