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State of the Art in Carbon Nanomaterials for Photoacoustic Imaging

Photoacoustic imaging using energy conversion from light to ultrasound waves has been developed as a powerful tool to investigate in vivo phenomena due to their complex characteristics. In photoacoustic imaging, endogenous chromophores such as oxygenated hemoglobin, deoxygenated hemoglobin, melanin,...

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Autores principales: Kang, Moon Sung, Lee, Haeni, Jeong, Seung Jo, Eom, Tae Joong, Kim, Jeesu, Han, Dong-Wook
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9219987/
https://www.ncbi.nlm.nih.gov/pubmed/35740396
http://dx.doi.org/10.3390/biomedicines10061374
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author Kang, Moon Sung
Lee, Haeni
Jeong, Seung Jo
Eom, Tae Joong
Kim, Jeesu
Han, Dong-Wook
author_facet Kang, Moon Sung
Lee, Haeni
Jeong, Seung Jo
Eom, Tae Joong
Kim, Jeesu
Han, Dong-Wook
author_sort Kang, Moon Sung
collection PubMed
description Photoacoustic imaging using energy conversion from light to ultrasound waves has been developed as a powerful tool to investigate in vivo phenomena due to their complex characteristics. In photoacoustic imaging, endogenous chromophores such as oxygenated hemoglobin, deoxygenated hemoglobin, melanin, and lipid provide useful biomedical information at the molecular level. However, these intrinsic absorbers show strong absorbance only in visible or infrared optical windows and have limited light transmission, making them difficult to apply for clinical translation. Therefore, the development of novel exogenous contrast agents capable of increasing imaging depth while ensuring strong light absorption is required. We report here the application of carbon nanomaterials that exhibit unique physical, mechanical, and electrochemical properties as imaging probes in photoacoustic imaging. Classified into specific structures, carbon nanomaterials are synthesized with different substances according to the imaging purposes to modulate the absorption spectra and highly enhance photoacoustic signals. In addition, functional drugs can be loaded into the carbon nanomaterials composite, and effective in vivo monitoring and photothermal therapy can be performed with cell-specific targeting. Diverse applied cases suggest the high potential of carbon nanomaterial-based photoacoustic imaging in in vivo monitoring for clinical research.
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spelling pubmed-92199872022-06-24 State of the Art in Carbon Nanomaterials for Photoacoustic Imaging Kang, Moon Sung Lee, Haeni Jeong, Seung Jo Eom, Tae Joong Kim, Jeesu Han, Dong-Wook Biomedicines Review Photoacoustic imaging using energy conversion from light to ultrasound waves has been developed as a powerful tool to investigate in vivo phenomena due to their complex characteristics. In photoacoustic imaging, endogenous chromophores such as oxygenated hemoglobin, deoxygenated hemoglobin, melanin, and lipid provide useful biomedical information at the molecular level. However, these intrinsic absorbers show strong absorbance only in visible or infrared optical windows and have limited light transmission, making them difficult to apply for clinical translation. Therefore, the development of novel exogenous contrast agents capable of increasing imaging depth while ensuring strong light absorption is required. We report here the application of carbon nanomaterials that exhibit unique physical, mechanical, and electrochemical properties as imaging probes in photoacoustic imaging. Classified into specific structures, carbon nanomaterials are synthesized with different substances according to the imaging purposes to modulate the absorption spectra and highly enhance photoacoustic signals. In addition, functional drugs can be loaded into the carbon nanomaterials composite, and effective in vivo monitoring and photothermal therapy can be performed with cell-specific targeting. Diverse applied cases suggest the high potential of carbon nanomaterial-based photoacoustic imaging in in vivo monitoring for clinical research. MDPI 2022-06-10 /pmc/articles/PMC9219987/ /pubmed/35740396 http://dx.doi.org/10.3390/biomedicines10061374 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Kang, Moon Sung
Lee, Haeni
Jeong, Seung Jo
Eom, Tae Joong
Kim, Jeesu
Han, Dong-Wook
State of the Art in Carbon Nanomaterials for Photoacoustic Imaging
title State of the Art in Carbon Nanomaterials for Photoacoustic Imaging
title_full State of the Art in Carbon Nanomaterials for Photoacoustic Imaging
title_fullStr State of the Art in Carbon Nanomaterials for Photoacoustic Imaging
title_full_unstemmed State of the Art in Carbon Nanomaterials for Photoacoustic Imaging
title_short State of the Art in Carbon Nanomaterials for Photoacoustic Imaging
title_sort state of the art in carbon nanomaterials for photoacoustic imaging
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9219987/
https://www.ncbi.nlm.nih.gov/pubmed/35740396
http://dx.doi.org/10.3390/biomedicines10061374
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