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A Metabolomic Profiling of Intra-Uterine Growth Restriction in Placenta and Cord Blood Points to an Impairment of Lipid and Energetic Metabolism

(1) Background: Intrauterine growth restriction (IUGR) involves metabolic changes that may be responsible for an increased risk of metabolic and cardiovascular diseases in adulthood. Several metabolomic profiles have been reported in maternal blood and urine, amniotic fluid, cord blood and newborn u...

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Autores principales: Chao de la Barca, Juan Manuel, Chabrun, Floris, Lefebvre, Tiphaine, Roche, Ombeline, Huetz, Noémie, Blanchet, Odile, Legendre, Guillaume, Simard, Gilles, Reynier, Pascal, Gascoin, Géraldine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9220006/
https://www.ncbi.nlm.nih.gov/pubmed/35740432
http://dx.doi.org/10.3390/biomedicines10061411
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author Chao de la Barca, Juan Manuel
Chabrun, Floris
Lefebvre, Tiphaine
Roche, Ombeline
Huetz, Noémie
Blanchet, Odile
Legendre, Guillaume
Simard, Gilles
Reynier, Pascal
Gascoin, Géraldine
author_facet Chao de la Barca, Juan Manuel
Chabrun, Floris
Lefebvre, Tiphaine
Roche, Ombeline
Huetz, Noémie
Blanchet, Odile
Legendre, Guillaume
Simard, Gilles
Reynier, Pascal
Gascoin, Géraldine
author_sort Chao de la Barca, Juan Manuel
collection PubMed
description (1) Background: Intrauterine growth restriction (IUGR) involves metabolic changes that may be responsible for an increased risk of metabolic and cardiovascular diseases in adulthood. Several metabolomic profiles have been reported in maternal blood and urine, amniotic fluid, cord blood and newborn urine, but the placenta has been poorly studied so far. (2) Methods: To decipher the origin of this metabolic reprogramming, we conducted a targeted metabolomics study replicated in two cohorts of placenta and one cohort of cord blood by measuring 188 metabolites by mass spectrometry. (3) Results: OPLS-DA multivariate analyses enabled clear discriminations between IUGR and controls, with good predictive capabilities and low overfitting in the two placental cohorts and in cord blood. A signature of 25 discriminating metabolites shared by both placental cohorts was identified. This signature points to sharp impairment of lipid and mitochondrial metabolism with an increased reliance on the creatine-phosphocreatine system by IUGR placentas. Increased placental insulin resistance and significant alteration of fatty acids oxidation, together with relatively higher phospholipase activity in IUGR placentas, were also highlighted. (4) Conclusions: Our results show a deep lipid and energetic remodeling in IUGR placentas that may have a lasting effect on the fetal metabolism.
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spelling pubmed-92200062022-06-24 A Metabolomic Profiling of Intra-Uterine Growth Restriction in Placenta and Cord Blood Points to an Impairment of Lipid and Energetic Metabolism Chao de la Barca, Juan Manuel Chabrun, Floris Lefebvre, Tiphaine Roche, Ombeline Huetz, Noémie Blanchet, Odile Legendre, Guillaume Simard, Gilles Reynier, Pascal Gascoin, Géraldine Biomedicines Article (1) Background: Intrauterine growth restriction (IUGR) involves metabolic changes that may be responsible for an increased risk of metabolic and cardiovascular diseases in adulthood. Several metabolomic profiles have been reported in maternal blood and urine, amniotic fluid, cord blood and newborn urine, but the placenta has been poorly studied so far. (2) Methods: To decipher the origin of this metabolic reprogramming, we conducted a targeted metabolomics study replicated in two cohorts of placenta and one cohort of cord blood by measuring 188 metabolites by mass spectrometry. (3) Results: OPLS-DA multivariate analyses enabled clear discriminations between IUGR and controls, with good predictive capabilities and low overfitting in the two placental cohorts and in cord blood. A signature of 25 discriminating metabolites shared by both placental cohorts was identified. This signature points to sharp impairment of lipid and mitochondrial metabolism with an increased reliance on the creatine-phosphocreatine system by IUGR placentas. Increased placental insulin resistance and significant alteration of fatty acids oxidation, together with relatively higher phospholipase activity in IUGR placentas, were also highlighted. (4) Conclusions: Our results show a deep lipid and energetic remodeling in IUGR placentas that may have a lasting effect on the fetal metabolism. MDPI 2022-06-15 /pmc/articles/PMC9220006/ /pubmed/35740432 http://dx.doi.org/10.3390/biomedicines10061411 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Chao de la Barca, Juan Manuel
Chabrun, Floris
Lefebvre, Tiphaine
Roche, Ombeline
Huetz, Noémie
Blanchet, Odile
Legendre, Guillaume
Simard, Gilles
Reynier, Pascal
Gascoin, Géraldine
A Metabolomic Profiling of Intra-Uterine Growth Restriction in Placenta and Cord Blood Points to an Impairment of Lipid and Energetic Metabolism
title A Metabolomic Profiling of Intra-Uterine Growth Restriction in Placenta and Cord Blood Points to an Impairment of Lipid and Energetic Metabolism
title_full A Metabolomic Profiling of Intra-Uterine Growth Restriction in Placenta and Cord Blood Points to an Impairment of Lipid and Energetic Metabolism
title_fullStr A Metabolomic Profiling of Intra-Uterine Growth Restriction in Placenta and Cord Blood Points to an Impairment of Lipid and Energetic Metabolism
title_full_unstemmed A Metabolomic Profiling of Intra-Uterine Growth Restriction in Placenta and Cord Blood Points to an Impairment of Lipid and Energetic Metabolism
title_short A Metabolomic Profiling of Intra-Uterine Growth Restriction in Placenta and Cord Blood Points to an Impairment of Lipid and Energetic Metabolism
title_sort metabolomic profiling of intra-uterine growth restriction in placenta and cord blood points to an impairment of lipid and energetic metabolism
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9220006/
https://www.ncbi.nlm.nih.gov/pubmed/35740432
http://dx.doi.org/10.3390/biomedicines10061411
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