Comparison of CD3e Antibody and CD3e-sZAP Immunotoxin Treatment in Mice Identifies sZAP as the Main Driver of Vascular Leakage

Anti-CD3-epsilon (CD3e) monoclonal antibodies (mAbs) and CD3e immunotoxins (ITs) are promising targeted therapy options for various T-cell disorders. Despite significant advances in mAb and IT engineering, vascular leakage syndrome (VLS) remains a major dose-limiting toxicity for ITs and has been po...

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Detalles Bibliográficos
Autores principales: Kim, Shihyoung, Shukla, Rajni Kant, Kim, Eunsoo, Cressman, Sophie G., Yu, Hannah, Baek, Alice, Choi, Hyewon, Kim, Alan, Sharma, Amit, Wang, Zhirui, Huang, Christene A., Reneau, John C., Boyaka, Prosper N., Liyanage, Namal P. M., Kim, Sanggu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9220018/
https://www.ncbi.nlm.nih.gov/pubmed/35740248
http://dx.doi.org/10.3390/biomedicines10061221

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