Cargando…
Reactive Sulfur Compounds in the Fight against COVID-19
The SARS-CoV-2 coronavirus pandemic outbreak in 2019 resulted in the need to search for an effective and safe strategy for treating infected patients, relieving symptoms, and preventing severe disease. SARS-CoV-2 is an RNA virus that can cause acute respiratory failure and thrombosis, as well as imp...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9220020/ https://www.ncbi.nlm.nih.gov/pubmed/35739949 http://dx.doi.org/10.3390/antiox11061053 |
_version_ | 1784732268284084224 |
---|---|
author | Iciek, Małgorzata Bilska-Wilkosz, Anna Kozdrowicki, Michał Górny, Magdalena |
author_facet | Iciek, Małgorzata Bilska-Wilkosz, Anna Kozdrowicki, Michał Górny, Magdalena |
author_sort | Iciek, Małgorzata |
collection | PubMed |
description | The SARS-CoV-2 coronavirus pandemic outbreak in 2019 resulted in the need to search for an effective and safe strategy for treating infected patients, relieving symptoms, and preventing severe disease. SARS-CoV-2 is an RNA virus that can cause acute respiratory failure and thrombosis, as well as impair circulatory system function. Permanent damage to the heart muscle or other cardiovascular disorders may occur during or after the infection. The severe course of the disease is associated with the release of large amounts of pro-inflammatory cytokines. Due to their documented anti-inflammatory, antioxidant, and antiviral effects, reactive sulfur compounds, including hydrogen sulfide (H(2)S), lipoic acid (LA), N-acetylcysteine (NAC), glutathione (GSH), and some other lesser-known sulfur compounds, have attracted the interest of scientists for the treatment and prevention of the adverse effects of diseases caused by SARS-CoV-2. This article reviews current knowledge about various endogenous or exogenous reactive sulfur compounds and discusses the possibility, or in some cases the results, of their use in the treatment or prophylaxis of COVID-19. |
format | Online Article Text |
id | pubmed-9220020 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-92200202022-06-24 Reactive Sulfur Compounds in the Fight against COVID-19 Iciek, Małgorzata Bilska-Wilkosz, Anna Kozdrowicki, Michał Górny, Magdalena Antioxidants (Basel) Review The SARS-CoV-2 coronavirus pandemic outbreak in 2019 resulted in the need to search for an effective and safe strategy for treating infected patients, relieving symptoms, and preventing severe disease. SARS-CoV-2 is an RNA virus that can cause acute respiratory failure and thrombosis, as well as impair circulatory system function. Permanent damage to the heart muscle or other cardiovascular disorders may occur during or after the infection. The severe course of the disease is associated with the release of large amounts of pro-inflammatory cytokines. Due to their documented anti-inflammatory, antioxidant, and antiviral effects, reactive sulfur compounds, including hydrogen sulfide (H(2)S), lipoic acid (LA), N-acetylcysteine (NAC), glutathione (GSH), and some other lesser-known sulfur compounds, have attracted the interest of scientists for the treatment and prevention of the adverse effects of diseases caused by SARS-CoV-2. This article reviews current knowledge about various endogenous or exogenous reactive sulfur compounds and discusses the possibility, or in some cases the results, of their use in the treatment or prophylaxis of COVID-19. MDPI 2022-05-26 /pmc/articles/PMC9220020/ /pubmed/35739949 http://dx.doi.org/10.3390/antiox11061053 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Iciek, Małgorzata Bilska-Wilkosz, Anna Kozdrowicki, Michał Górny, Magdalena Reactive Sulfur Compounds in the Fight against COVID-19 |
title | Reactive Sulfur Compounds in the Fight against COVID-19 |
title_full | Reactive Sulfur Compounds in the Fight against COVID-19 |
title_fullStr | Reactive Sulfur Compounds in the Fight against COVID-19 |
title_full_unstemmed | Reactive Sulfur Compounds in the Fight against COVID-19 |
title_short | Reactive Sulfur Compounds in the Fight against COVID-19 |
title_sort | reactive sulfur compounds in the fight against covid-19 |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9220020/ https://www.ncbi.nlm.nih.gov/pubmed/35739949 http://dx.doi.org/10.3390/antiox11061053 |
work_keys_str_mv | AT iciekmałgorzata reactivesulfurcompoundsinthefightagainstcovid19 AT bilskawilkoszanna reactivesulfurcompoundsinthefightagainstcovid19 AT kozdrowickimichał reactivesulfurcompoundsinthefightagainstcovid19 AT gornymagdalena reactivesulfurcompoundsinthefightagainstcovid19 |