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The Role of Salvage in the Management of Patients with Sinonasal Squamous Cell Carcinoma
Objectives: This paper presents and discusses the rate and outcome of salvage according to various factors for patients with sinonasal squamous cell carcinoma (SNSCC). Methods: Data of 79 patients treated radically due to SNSCC between 2000 and 2016 in the National Cancer Research Institute, Gliwice...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9220057/ https://www.ncbi.nlm.nih.gov/pubmed/35740287 http://dx.doi.org/10.3390/biomedicines10061266 |
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author | Kacorzyk, Urszula Rutkowski, Tomasz Wojciech |
author_facet | Kacorzyk, Urszula Rutkowski, Tomasz Wojciech |
author_sort | Kacorzyk, Urszula |
collection | PubMed |
description | Objectives: This paper presents and discusses the rate and outcome of salvage according to various factors for patients with sinonasal squamous cell carcinoma (SNSCC). Methods: Data of 79 patients treated radically due to SNSCC between 2000 and 2016 in the National Cancer Research Institute, Gliwice branch, were analyzed. Surgery was the primary treatment in 63 (79%) of patients. The ratio, type, and effectiveness of salvage was assessed and correlated with prognostic factors. Probabilities of overall survival (OS), local control (LC), nodal control (NC), and locoregional control (LRC) were assessed and compared between the groups. Results: The 5-year LC, NC, and LRC survival rates were 62%, 75%, and 53%, respectively. The 5-year OS rate was 51%. In 34 (43%) patients, treatment failure was reported, and salvage was performed in 17 (50%) of them. It was shown that patients after any salvage had significantly longer 2- and 3-year OS rates when compared to patients with no salvage: 52% vs. 7% and 38% vs. 0%, respectively (p = 0.004). Two- and three-year OS rates for patients after effective and ineffective salvage were 83% vs. 33% and 83% vs. 11%, respectively (p = 0.02). For patients with effective salvage, OS did not differ significantly when compared to the OS of primarily cured patients (p = 0.6). Conclusions: For SNSCC patients after treatment failure, salvage is possible in half of the cases and can improve their overall survival even if not finally successful. Moreover, effective salvage can compensate for the failure and give the same ultimate OS as in primarily cured patients. |
format | Online Article Text |
id | pubmed-9220057 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-92200572022-06-24 The Role of Salvage in the Management of Patients with Sinonasal Squamous Cell Carcinoma Kacorzyk, Urszula Rutkowski, Tomasz Wojciech Biomedicines Article Objectives: This paper presents and discusses the rate and outcome of salvage according to various factors for patients with sinonasal squamous cell carcinoma (SNSCC). Methods: Data of 79 patients treated radically due to SNSCC between 2000 and 2016 in the National Cancer Research Institute, Gliwice branch, were analyzed. Surgery was the primary treatment in 63 (79%) of patients. The ratio, type, and effectiveness of salvage was assessed and correlated with prognostic factors. Probabilities of overall survival (OS), local control (LC), nodal control (NC), and locoregional control (LRC) were assessed and compared between the groups. Results: The 5-year LC, NC, and LRC survival rates were 62%, 75%, and 53%, respectively. The 5-year OS rate was 51%. In 34 (43%) patients, treatment failure was reported, and salvage was performed in 17 (50%) of them. It was shown that patients after any salvage had significantly longer 2- and 3-year OS rates when compared to patients with no salvage: 52% vs. 7% and 38% vs. 0%, respectively (p = 0.004). Two- and three-year OS rates for patients after effective and ineffective salvage were 83% vs. 33% and 83% vs. 11%, respectively (p = 0.02). For patients with effective salvage, OS did not differ significantly when compared to the OS of primarily cured patients (p = 0.6). Conclusions: For SNSCC patients after treatment failure, salvage is possible in half of the cases and can improve their overall survival even if not finally successful. Moreover, effective salvage can compensate for the failure and give the same ultimate OS as in primarily cured patients. MDPI 2022-05-28 /pmc/articles/PMC9220057/ /pubmed/35740287 http://dx.doi.org/10.3390/biomedicines10061266 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Kacorzyk, Urszula Rutkowski, Tomasz Wojciech The Role of Salvage in the Management of Patients with Sinonasal Squamous Cell Carcinoma |
title | The Role of Salvage in the Management of Patients with Sinonasal Squamous Cell Carcinoma |
title_full | The Role of Salvage in the Management of Patients with Sinonasal Squamous Cell Carcinoma |
title_fullStr | The Role of Salvage in the Management of Patients with Sinonasal Squamous Cell Carcinoma |
title_full_unstemmed | The Role of Salvage in the Management of Patients with Sinonasal Squamous Cell Carcinoma |
title_short | The Role of Salvage in the Management of Patients with Sinonasal Squamous Cell Carcinoma |
title_sort | role of salvage in the management of patients with sinonasal squamous cell carcinoma |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9220057/ https://www.ncbi.nlm.nih.gov/pubmed/35740287 http://dx.doi.org/10.3390/biomedicines10061266 |
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