Cargando…

The Role of Salvage in the Management of Patients with Sinonasal Squamous Cell Carcinoma

Objectives: This paper presents and discusses the rate and outcome of salvage according to various factors for patients with sinonasal squamous cell carcinoma (SNSCC). Methods: Data of 79 patients treated radically due to SNSCC between 2000 and 2016 in the National Cancer Research Institute, Gliwice...

Descripción completa

Detalles Bibliográficos
Autores principales: Kacorzyk, Urszula, Rutkowski, Tomasz Wojciech
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9220057/
https://www.ncbi.nlm.nih.gov/pubmed/35740287
http://dx.doi.org/10.3390/biomedicines10061266
_version_ 1784732277885894656
author Kacorzyk, Urszula
Rutkowski, Tomasz Wojciech
author_facet Kacorzyk, Urszula
Rutkowski, Tomasz Wojciech
author_sort Kacorzyk, Urszula
collection PubMed
description Objectives: This paper presents and discusses the rate and outcome of salvage according to various factors for patients with sinonasal squamous cell carcinoma (SNSCC). Methods: Data of 79 patients treated radically due to SNSCC between 2000 and 2016 in the National Cancer Research Institute, Gliwice branch, were analyzed. Surgery was the primary treatment in 63 (79%) of patients. The ratio, type, and effectiveness of salvage was assessed and correlated with prognostic factors. Probabilities of overall survival (OS), local control (LC), nodal control (NC), and locoregional control (LRC) were assessed and compared between the groups. Results: The 5-year LC, NC, and LRC survival rates were 62%, 75%, and 53%, respectively. The 5-year OS rate was 51%. In 34 (43%) patients, treatment failure was reported, and salvage was performed in 17 (50%) of them. It was shown that patients after any salvage had significantly longer 2- and 3-year OS rates when compared to patients with no salvage: 52% vs. 7% and 38% vs. 0%, respectively (p = 0.004). Two- and three-year OS rates for patients after effective and ineffective salvage were 83% vs. 33% and 83% vs. 11%, respectively (p = 0.02). For patients with effective salvage, OS did not differ significantly when compared to the OS of primarily cured patients (p = 0.6). Conclusions: For SNSCC patients after treatment failure, salvage is possible in half of the cases and can improve their overall survival even if not finally successful. Moreover, effective salvage can compensate for the failure and give the same ultimate OS as in primarily cured patients.
format Online
Article
Text
id pubmed-9220057
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-92200572022-06-24 The Role of Salvage in the Management of Patients with Sinonasal Squamous Cell Carcinoma Kacorzyk, Urszula Rutkowski, Tomasz Wojciech Biomedicines Article Objectives: This paper presents and discusses the rate and outcome of salvage according to various factors for patients with sinonasal squamous cell carcinoma (SNSCC). Methods: Data of 79 patients treated radically due to SNSCC between 2000 and 2016 in the National Cancer Research Institute, Gliwice branch, were analyzed. Surgery was the primary treatment in 63 (79%) of patients. The ratio, type, and effectiveness of salvage was assessed and correlated with prognostic factors. Probabilities of overall survival (OS), local control (LC), nodal control (NC), and locoregional control (LRC) were assessed and compared between the groups. Results: The 5-year LC, NC, and LRC survival rates were 62%, 75%, and 53%, respectively. The 5-year OS rate was 51%. In 34 (43%) patients, treatment failure was reported, and salvage was performed in 17 (50%) of them. It was shown that patients after any salvage had significantly longer 2- and 3-year OS rates when compared to patients with no salvage: 52% vs. 7% and 38% vs. 0%, respectively (p = 0.004). Two- and three-year OS rates for patients after effective and ineffective salvage were 83% vs. 33% and 83% vs. 11%, respectively (p = 0.02). For patients with effective salvage, OS did not differ significantly when compared to the OS of primarily cured patients (p = 0.6). Conclusions: For SNSCC patients after treatment failure, salvage is possible in half of the cases and can improve their overall survival even if not finally successful. Moreover, effective salvage can compensate for the failure and give the same ultimate OS as in primarily cured patients. MDPI 2022-05-28 /pmc/articles/PMC9220057/ /pubmed/35740287 http://dx.doi.org/10.3390/biomedicines10061266 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kacorzyk, Urszula
Rutkowski, Tomasz Wojciech
The Role of Salvage in the Management of Patients with Sinonasal Squamous Cell Carcinoma
title The Role of Salvage in the Management of Patients with Sinonasal Squamous Cell Carcinoma
title_full The Role of Salvage in the Management of Patients with Sinonasal Squamous Cell Carcinoma
title_fullStr The Role of Salvage in the Management of Patients with Sinonasal Squamous Cell Carcinoma
title_full_unstemmed The Role of Salvage in the Management of Patients with Sinonasal Squamous Cell Carcinoma
title_short The Role of Salvage in the Management of Patients with Sinonasal Squamous Cell Carcinoma
title_sort role of salvage in the management of patients with sinonasal squamous cell carcinoma
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9220057/
https://www.ncbi.nlm.nih.gov/pubmed/35740287
http://dx.doi.org/10.3390/biomedicines10061266
work_keys_str_mv AT kacorzykurszula theroleofsalvageinthemanagementofpatientswithsinonasalsquamouscellcarcinoma
AT rutkowskitomaszwojciech theroleofsalvageinthemanagementofpatientswithsinonasalsquamouscellcarcinoma
AT kacorzykurszula roleofsalvageinthemanagementofpatientswithsinonasalsquamouscellcarcinoma
AT rutkowskitomaszwojciech roleofsalvageinthemanagementofpatientswithsinonasalsquamouscellcarcinoma