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Antioxidative Effects of Standardized Aronia melanocarpa Extract on Reproductive and Metabolic Disturbances in a Rat Model of Polycystic Ovary Syndrome

Polycystic ovary syndrome (PCOS) represents the most common endocrinopathy among childbearing-age women, with oxidative stress (OS) underlying its etiopathogenesis. Metformin (MET) represents a frequently used agent in PCOS. However, weak results encourage alternative treatments. We aimed to investi...

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Autores principales: Rudic, Jovan, Jakovljevic, Vladimir, Jovic, Nikola, Nikolic, Maja, Sretenovic, Jasmina, Mitrovic, Slobodanka, Bolevich, Sergey, Bolevich, Stefani, Mitrovic, Miroslav, Raicevic, Sasa, Andric, Kristina, Dimkic Milenkovic, Andjela, Rakic, Dejana, Joksimovic Jovic, Jovana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9220112/
https://www.ncbi.nlm.nih.gov/pubmed/35739998
http://dx.doi.org/10.3390/antiox11061099
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author Rudic, Jovan
Jakovljevic, Vladimir
Jovic, Nikola
Nikolic, Maja
Sretenovic, Jasmina
Mitrovic, Slobodanka
Bolevich, Sergey
Bolevich, Stefani
Mitrovic, Miroslav
Raicevic, Sasa
Andric, Kristina
Dimkic Milenkovic, Andjela
Rakic, Dejana
Joksimovic Jovic, Jovana
author_facet Rudic, Jovan
Jakovljevic, Vladimir
Jovic, Nikola
Nikolic, Maja
Sretenovic, Jasmina
Mitrovic, Slobodanka
Bolevich, Sergey
Bolevich, Stefani
Mitrovic, Miroslav
Raicevic, Sasa
Andric, Kristina
Dimkic Milenkovic, Andjela
Rakic, Dejana
Joksimovic Jovic, Jovana
author_sort Rudic, Jovan
collection PubMed
description Polycystic ovary syndrome (PCOS) represents the most common endocrinopathy among childbearing-age women, with oxidative stress (OS) underlying its etiopathogenesis. Metformin (MET) represents a frequently used agent in PCOS. However, weak results encourage alternative treatments. We aimed to investigate isolated and synergistic effects of Standardized Aronia melanocarpa extract (SEA) and MET for alleviating reproductive and metabolic PCOS abnormalities. PCOS induction was followed by 28-day treatment with MET, SAE, or MET + SEA. Bodyweight (BW), cyclicity, histological, and ultrasonographical ovarian analyses were performed. Hormonal, glycemic, and lipid profiles were accessed, as well as systemic and ovarian oxidative status; BW, cyclicity, ovarian histomorphology, ovarian volume, testosterone and progesterone levels, as well as LDL, triglycerides, and total cholesterol levels were aggravated after PCOS-induction and improved after MET, SEA, and MET + SEA treatment. MET + SEA had the greatest impact on glycoregulation. Alterations in OS parameters (TBARS, O(2)(−), H(2)O(2), catalase, superoxide dismutase, and reduced glutathione) could be responsible for observed differences; (4) Conclusions: Our findings confirmed that SAE alone or along with MET was capable of ameliorating reproductive and metabolic disturbances in the PCOS rat model, with the restoration of OS parameters. SAE alone did not alter the protective effects of MET in PCOS.
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spelling pubmed-92201122022-06-24 Antioxidative Effects of Standardized Aronia melanocarpa Extract on Reproductive and Metabolic Disturbances in a Rat Model of Polycystic Ovary Syndrome Rudic, Jovan Jakovljevic, Vladimir Jovic, Nikola Nikolic, Maja Sretenovic, Jasmina Mitrovic, Slobodanka Bolevich, Sergey Bolevich, Stefani Mitrovic, Miroslav Raicevic, Sasa Andric, Kristina Dimkic Milenkovic, Andjela Rakic, Dejana Joksimovic Jovic, Jovana Antioxidants (Basel) Article Polycystic ovary syndrome (PCOS) represents the most common endocrinopathy among childbearing-age women, with oxidative stress (OS) underlying its etiopathogenesis. Metformin (MET) represents a frequently used agent in PCOS. However, weak results encourage alternative treatments. We aimed to investigate isolated and synergistic effects of Standardized Aronia melanocarpa extract (SEA) and MET for alleviating reproductive and metabolic PCOS abnormalities. PCOS induction was followed by 28-day treatment with MET, SAE, or MET + SEA. Bodyweight (BW), cyclicity, histological, and ultrasonographical ovarian analyses were performed. Hormonal, glycemic, and lipid profiles were accessed, as well as systemic and ovarian oxidative status; BW, cyclicity, ovarian histomorphology, ovarian volume, testosterone and progesterone levels, as well as LDL, triglycerides, and total cholesterol levels were aggravated after PCOS-induction and improved after MET, SEA, and MET + SEA treatment. MET + SEA had the greatest impact on glycoregulation. Alterations in OS parameters (TBARS, O(2)(−), H(2)O(2), catalase, superoxide dismutase, and reduced glutathione) could be responsible for observed differences; (4) Conclusions: Our findings confirmed that SAE alone or along with MET was capable of ameliorating reproductive and metabolic disturbances in the PCOS rat model, with the restoration of OS parameters. SAE alone did not alter the protective effects of MET in PCOS. MDPI 2022-05-31 /pmc/articles/PMC9220112/ /pubmed/35739998 http://dx.doi.org/10.3390/antiox11061099 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Rudic, Jovan
Jakovljevic, Vladimir
Jovic, Nikola
Nikolic, Maja
Sretenovic, Jasmina
Mitrovic, Slobodanka
Bolevich, Sergey
Bolevich, Stefani
Mitrovic, Miroslav
Raicevic, Sasa
Andric, Kristina
Dimkic Milenkovic, Andjela
Rakic, Dejana
Joksimovic Jovic, Jovana
Antioxidative Effects of Standardized Aronia melanocarpa Extract on Reproductive and Metabolic Disturbances in a Rat Model of Polycystic Ovary Syndrome
title Antioxidative Effects of Standardized Aronia melanocarpa Extract on Reproductive and Metabolic Disturbances in a Rat Model of Polycystic Ovary Syndrome
title_full Antioxidative Effects of Standardized Aronia melanocarpa Extract on Reproductive and Metabolic Disturbances in a Rat Model of Polycystic Ovary Syndrome
title_fullStr Antioxidative Effects of Standardized Aronia melanocarpa Extract on Reproductive and Metabolic Disturbances in a Rat Model of Polycystic Ovary Syndrome
title_full_unstemmed Antioxidative Effects of Standardized Aronia melanocarpa Extract on Reproductive and Metabolic Disturbances in a Rat Model of Polycystic Ovary Syndrome
title_short Antioxidative Effects of Standardized Aronia melanocarpa Extract on Reproductive and Metabolic Disturbances in a Rat Model of Polycystic Ovary Syndrome
title_sort antioxidative effects of standardized aronia melanocarpa extract on reproductive and metabolic disturbances in a rat model of polycystic ovary syndrome
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9220112/
https://www.ncbi.nlm.nih.gov/pubmed/35739998
http://dx.doi.org/10.3390/antiox11061099
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