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Therapy Effect of the Stable Gastric Pentadecapeptide BPC 157 on Acute Pancreatitis as Vascular Failure-Induced Severe Peripheral and Central Syndrome in Rats

We revealed the therapy effect of the stable gastric pentadecapeptide BPC 157 (10 μg/kg, 10 ng/kg ig or po) with specific activation of the collateral rescuing pathways, the azygos vein, on bile duct ligation in particular, and acute pancreatitis as local disturbances (i.e., improved gross and micro...

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Autores principales: Smoday, Ivan Maria, Petrovic, Igor, Kalogjera, Luka, Vranes, Hrvoje, Zizek, Helena, Krezic, Ivan, Gojkovic, Slaven, Skorak, Ivan, Hriberski, Klaudija, Brizic, Ivan, Kubat, Milovan, Strbe, Sanja, Barisic, Ivan, Sola, Marija, Lovric, Eva, Lozic, Marin, Boban Blagaic, Alenka, Skrtic, Anita, Seiwerth, Sven, Sikiric, Predrag
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9220115/
https://www.ncbi.nlm.nih.gov/pubmed/35740321
http://dx.doi.org/10.3390/biomedicines10061299
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author Smoday, Ivan Maria
Petrovic, Igor
Kalogjera, Luka
Vranes, Hrvoje
Zizek, Helena
Krezic, Ivan
Gojkovic, Slaven
Skorak, Ivan
Hriberski, Klaudija
Brizic, Ivan
Kubat, Milovan
Strbe, Sanja
Barisic, Ivan
Sola, Marija
Lovric, Eva
Lozic, Marin
Boban Blagaic, Alenka
Skrtic, Anita
Seiwerth, Sven
Sikiric, Predrag
author_facet Smoday, Ivan Maria
Petrovic, Igor
Kalogjera, Luka
Vranes, Hrvoje
Zizek, Helena
Krezic, Ivan
Gojkovic, Slaven
Skorak, Ivan
Hriberski, Klaudija
Brizic, Ivan
Kubat, Milovan
Strbe, Sanja
Barisic, Ivan
Sola, Marija
Lovric, Eva
Lozic, Marin
Boban Blagaic, Alenka
Skrtic, Anita
Seiwerth, Sven
Sikiric, Predrag
author_sort Smoday, Ivan Maria
collection PubMed
description We revealed the therapy effect of the stable gastric pentadecapeptide BPC 157 (10 μg/kg, 10 ng/kg ig or po) with specific activation of the collateral rescuing pathways, the azygos vein, on bile duct ligation in particular, and acute pancreatitis as local disturbances (i.e., improved gross and microscopy presentation, decreased amylase level). Additionally, we revealed the therapy’s effect on the acute pancreatitis as vascular failure and multiorgan failure, both peripherally and centrally following “occlusion-like” syndrome, major intoxication (alcohol, lithium), maintained severe intra-abdominal hypertension, and myocardial infarction, or occlusion syndrome, and major vessel occlusion. The application-sacrifice periods were ligation times of 0–30 min, 0–5 h, 0–24 h (cured periods, early regimen) and 4.30 h–5 h, 5 h–24 h (cured periods, delayed regimen). Otherwise, bile duct-ligated rats commonly presented intracranial (superior sagittal sinus), portal and caval hypertension and aortal hypotension, gross brain swelling, hemorrhage and lesions, heart dysfunction, lung lesions, liver and kidney failure, gastrointestinal lesions, and severe arterial and venous thrombosis, peripherally and centrally. Unless antagonized with the key effect of BPC 157 regimens, reversal of the inferior caval and superior mesenteric vein congestion and reversal of the failed azygos vein activated azygos vein-recruited direct delivery to rescue the inferior-superior caval vein pathway; these were all antecedent to acute pancreatitis major lesions (i.e., acinar, fat necrosis, hemorrhage). These lesions appeared in the later period, but were markedly attenuated/eliminated (i.e., hemorrhage) in BPC 157-treated rats. To summarize, while the innate vicious cycle may be peripheral (bile duct ligation), or central (rapidly developed brain disturbances), or peripheral and central, BPC 157 resolved acute pancreatitis and its adjacent syndrome.
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spelling pubmed-92201152022-06-24 Therapy Effect of the Stable Gastric Pentadecapeptide BPC 157 on Acute Pancreatitis as Vascular Failure-Induced Severe Peripheral and Central Syndrome in Rats Smoday, Ivan Maria Petrovic, Igor Kalogjera, Luka Vranes, Hrvoje Zizek, Helena Krezic, Ivan Gojkovic, Slaven Skorak, Ivan Hriberski, Klaudija Brizic, Ivan Kubat, Milovan Strbe, Sanja Barisic, Ivan Sola, Marija Lovric, Eva Lozic, Marin Boban Blagaic, Alenka Skrtic, Anita Seiwerth, Sven Sikiric, Predrag Biomedicines Article We revealed the therapy effect of the stable gastric pentadecapeptide BPC 157 (10 μg/kg, 10 ng/kg ig or po) with specific activation of the collateral rescuing pathways, the azygos vein, on bile duct ligation in particular, and acute pancreatitis as local disturbances (i.e., improved gross and microscopy presentation, decreased amylase level). Additionally, we revealed the therapy’s effect on the acute pancreatitis as vascular failure and multiorgan failure, both peripherally and centrally following “occlusion-like” syndrome, major intoxication (alcohol, lithium), maintained severe intra-abdominal hypertension, and myocardial infarction, or occlusion syndrome, and major vessel occlusion. The application-sacrifice periods were ligation times of 0–30 min, 0–5 h, 0–24 h (cured periods, early regimen) and 4.30 h–5 h, 5 h–24 h (cured periods, delayed regimen). Otherwise, bile duct-ligated rats commonly presented intracranial (superior sagittal sinus), portal and caval hypertension and aortal hypotension, gross brain swelling, hemorrhage and lesions, heart dysfunction, lung lesions, liver and kidney failure, gastrointestinal lesions, and severe arterial and venous thrombosis, peripherally and centrally. Unless antagonized with the key effect of BPC 157 regimens, reversal of the inferior caval and superior mesenteric vein congestion and reversal of the failed azygos vein activated azygos vein-recruited direct delivery to rescue the inferior-superior caval vein pathway; these were all antecedent to acute pancreatitis major lesions (i.e., acinar, fat necrosis, hemorrhage). These lesions appeared in the later period, but were markedly attenuated/eliminated (i.e., hemorrhage) in BPC 157-treated rats. To summarize, while the innate vicious cycle may be peripheral (bile duct ligation), or central (rapidly developed brain disturbances), or peripheral and central, BPC 157 resolved acute pancreatitis and its adjacent syndrome. MDPI 2022-06-01 /pmc/articles/PMC9220115/ /pubmed/35740321 http://dx.doi.org/10.3390/biomedicines10061299 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Smoday, Ivan Maria
Petrovic, Igor
Kalogjera, Luka
Vranes, Hrvoje
Zizek, Helena
Krezic, Ivan
Gojkovic, Slaven
Skorak, Ivan
Hriberski, Klaudija
Brizic, Ivan
Kubat, Milovan
Strbe, Sanja
Barisic, Ivan
Sola, Marija
Lovric, Eva
Lozic, Marin
Boban Blagaic, Alenka
Skrtic, Anita
Seiwerth, Sven
Sikiric, Predrag
Therapy Effect of the Stable Gastric Pentadecapeptide BPC 157 on Acute Pancreatitis as Vascular Failure-Induced Severe Peripheral and Central Syndrome in Rats
title Therapy Effect of the Stable Gastric Pentadecapeptide BPC 157 on Acute Pancreatitis as Vascular Failure-Induced Severe Peripheral and Central Syndrome in Rats
title_full Therapy Effect of the Stable Gastric Pentadecapeptide BPC 157 on Acute Pancreatitis as Vascular Failure-Induced Severe Peripheral and Central Syndrome in Rats
title_fullStr Therapy Effect of the Stable Gastric Pentadecapeptide BPC 157 on Acute Pancreatitis as Vascular Failure-Induced Severe Peripheral and Central Syndrome in Rats
title_full_unstemmed Therapy Effect of the Stable Gastric Pentadecapeptide BPC 157 on Acute Pancreatitis as Vascular Failure-Induced Severe Peripheral and Central Syndrome in Rats
title_short Therapy Effect of the Stable Gastric Pentadecapeptide BPC 157 on Acute Pancreatitis as Vascular Failure-Induced Severe Peripheral and Central Syndrome in Rats
title_sort therapy effect of the stable gastric pentadecapeptide bpc 157 on acute pancreatitis as vascular failure-induced severe peripheral and central syndrome in rats
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9220115/
https://www.ncbi.nlm.nih.gov/pubmed/35740321
http://dx.doi.org/10.3390/biomedicines10061299
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