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Therapy Effect of the Stable Gastric Pentadecapeptide BPC 157 on Acute Pancreatitis as Vascular Failure-Induced Severe Peripheral and Central Syndrome in Rats
We revealed the therapy effect of the stable gastric pentadecapeptide BPC 157 (10 μg/kg, 10 ng/kg ig or po) with specific activation of the collateral rescuing pathways, the azygos vein, on bile duct ligation in particular, and acute pancreatitis as local disturbances (i.e., improved gross and micro...
Autores principales: | , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9220115/ https://www.ncbi.nlm.nih.gov/pubmed/35740321 http://dx.doi.org/10.3390/biomedicines10061299 |
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author | Smoday, Ivan Maria Petrovic, Igor Kalogjera, Luka Vranes, Hrvoje Zizek, Helena Krezic, Ivan Gojkovic, Slaven Skorak, Ivan Hriberski, Klaudija Brizic, Ivan Kubat, Milovan Strbe, Sanja Barisic, Ivan Sola, Marija Lovric, Eva Lozic, Marin Boban Blagaic, Alenka Skrtic, Anita Seiwerth, Sven Sikiric, Predrag |
author_facet | Smoday, Ivan Maria Petrovic, Igor Kalogjera, Luka Vranes, Hrvoje Zizek, Helena Krezic, Ivan Gojkovic, Slaven Skorak, Ivan Hriberski, Klaudija Brizic, Ivan Kubat, Milovan Strbe, Sanja Barisic, Ivan Sola, Marija Lovric, Eva Lozic, Marin Boban Blagaic, Alenka Skrtic, Anita Seiwerth, Sven Sikiric, Predrag |
author_sort | Smoday, Ivan Maria |
collection | PubMed |
description | We revealed the therapy effect of the stable gastric pentadecapeptide BPC 157 (10 μg/kg, 10 ng/kg ig or po) with specific activation of the collateral rescuing pathways, the azygos vein, on bile duct ligation in particular, and acute pancreatitis as local disturbances (i.e., improved gross and microscopy presentation, decreased amylase level). Additionally, we revealed the therapy’s effect on the acute pancreatitis as vascular failure and multiorgan failure, both peripherally and centrally following “occlusion-like” syndrome, major intoxication (alcohol, lithium), maintained severe intra-abdominal hypertension, and myocardial infarction, or occlusion syndrome, and major vessel occlusion. The application-sacrifice periods were ligation times of 0–30 min, 0–5 h, 0–24 h (cured periods, early regimen) and 4.30 h–5 h, 5 h–24 h (cured periods, delayed regimen). Otherwise, bile duct-ligated rats commonly presented intracranial (superior sagittal sinus), portal and caval hypertension and aortal hypotension, gross brain swelling, hemorrhage and lesions, heart dysfunction, lung lesions, liver and kidney failure, gastrointestinal lesions, and severe arterial and venous thrombosis, peripherally and centrally. Unless antagonized with the key effect of BPC 157 regimens, reversal of the inferior caval and superior mesenteric vein congestion and reversal of the failed azygos vein activated azygos vein-recruited direct delivery to rescue the inferior-superior caval vein pathway; these were all antecedent to acute pancreatitis major lesions (i.e., acinar, fat necrosis, hemorrhage). These lesions appeared in the later period, but were markedly attenuated/eliminated (i.e., hemorrhage) in BPC 157-treated rats. To summarize, while the innate vicious cycle may be peripheral (bile duct ligation), or central (rapidly developed brain disturbances), or peripheral and central, BPC 157 resolved acute pancreatitis and its adjacent syndrome. |
format | Online Article Text |
id | pubmed-9220115 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-92201152022-06-24 Therapy Effect of the Stable Gastric Pentadecapeptide BPC 157 on Acute Pancreatitis as Vascular Failure-Induced Severe Peripheral and Central Syndrome in Rats Smoday, Ivan Maria Petrovic, Igor Kalogjera, Luka Vranes, Hrvoje Zizek, Helena Krezic, Ivan Gojkovic, Slaven Skorak, Ivan Hriberski, Klaudija Brizic, Ivan Kubat, Milovan Strbe, Sanja Barisic, Ivan Sola, Marija Lovric, Eva Lozic, Marin Boban Blagaic, Alenka Skrtic, Anita Seiwerth, Sven Sikiric, Predrag Biomedicines Article We revealed the therapy effect of the stable gastric pentadecapeptide BPC 157 (10 μg/kg, 10 ng/kg ig or po) with specific activation of the collateral rescuing pathways, the azygos vein, on bile duct ligation in particular, and acute pancreatitis as local disturbances (i.e., improved gross and microscopy presentation, decreased amylase level). Additionally, we revealed the therapy’s effect on the acute pancreatitis as vascular failure and multiorgan failure, both peripherally and centrally following “occlusion-like” syndrome, major intoxication (alcohol, lithium), maintained severe intra-abdominal hypertension, and myocardial infarction, or occlusion syndrome, and major vessel occlusion. The application-sacrifice periods were ligation times of 0–30 min, 0–5 h, 0–24 h (cured periods, early regimen) and 4.30 h–5 h, 5 h–24 h (cured periods, delayed regimen). Otherwise, bile duct-ligated rats commonly presented intracranial (superior sagittal sinus), portal and caval hypertension and aortal hypotension, gross brain swelling, hemorrhage and lesions, heart dysfunction, lung lesions, liver and kidney failure, gastrointestinal lesions, and severe arterial and venous thrombosis, peripherally and centrally. Unless antagonized with the key effect of BPC 157 regimens, reversal of the inferior caval and superior mesenteric vein congestion and reversal of the failed azygos vein activated azygos vein-recruited direct delivery to rescue the inferior-superior caval vein pathway; these were all antecedent to acute pancreatitis major lesions (i.e., acinar, fat necrosis, hemorrhage). These lesions appeared in the later period, but were markedly attenuated/eliminated (i.e., hemorrhage) in BPC 157-treated rats. To summarize, while the innate vicious cycle may be peripheral (bile duct ligation), or central (rapidly developed brain disturbances), or peripheral and central, BPC 157 resolved acute pancreatitis and its adjacent syndrome. MDPI 2022-06-01 /pmc/articles/PMC9220115/ /pubmed/35740321 http://dx.doi.org/10.3390/biomedicines10061299 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Smoday, Ivan Maria Petrovic, Igor Kalogjera, Luka Vranes, Hrvoje Zizek, Helena Krezic, Ivan Gojkovic, Slaven Skorak, Ivan Hriberski, Klaudija Brizic, Ivan Kubat, Milovan Strbe, Sanja Barisic, Ivan Sola, Marija Lovric, Eva Lozic, Marin Boban Blagaic, Alenka Skrtic, Anita Seiwerth, Sven Sikiric, Predrag Therapy Effect of the Stable Gastric Pentadecapeptide BPC 157 on Acute Pancreatitis as Vascular Failure-Induced Severe Peripheral and Central Syndrome in Rats |
title | Therapy Effect of the Stable Gastric Pentadecapeptide BPC 157 on Acute Pancreatitis as Vascular Failure-Induced Severe Peripheral and Central Syndrome in Rats |
title_full | Therapy Effect of the Stable Gastric Pentadecapeptide BPC 157 on Acute Pancreatitis as Vascular Failure-Induced Severe Peripheral and Central Syndrome in Rats |
title_fullStr | Therapy Effect of the Stable Gastric Pentadecapeptide BPC 157 on Acute Pancreatitis as Vascular Failure-Induced Severe Peripheral and Central Syndrome in Rats |
title_full_unstemmed | Therapy Effect of the Stable Gastric Pentadecapeptide BPC 157 on Acute Pancreatitis as Vascular Failure-Induced Severe Peripheral and Central Syndrome in Rats |
title_short | Therapy Effect of the Stable Gastric Pentadecapeptide BPC 157 on Acute Pancreatitis as Vascular Failure-Induced Severe Peripheral and Central Syndrome in Rats |
title_sort | therapy effect of the stable gastric pentadecapeptide bpc 157 on acute pancreatitis as vascular failure-induced severe peripheral and central syndrome in rats |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9220115/ https://www.ncbi.nlm.nih.gov/pubmed/35740321 http://dx.doi.org/10.3390/biomedicines10061299 |
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