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Pattern of Antibiotic Use among Hospitalized Patients according to WHO Access, Watch, Reserve (AWaRe) Classification: Findings from a Point Prevalence Survey in Bangladesh

For supporting antibiotic stewardship interventions, the World Health Organization (WHO) classified antibiotics through the AWaRe (Access, Watch, and Reserve) classification. Inappropriate use of antimicrobials among hospital-admitted patients exposes them to the vulnerability of developing resistan...

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Autores principales: Rashid, Md. Mahbubur, Akhtar, Zubair, Chowdhury, Sukanta, Islam, Md. Ariful, Parveen, Shahana, Ghosh, Probir Kumar, Rahman, Aninda, Khan, Zobaidul Haque, Islam, Khaleda, Debnath, Nitish, Rahman, Mahmudur, Chowdhury, Fahmida
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9220119/
https://www.ncbi.nlm.nih.gov/pubmed/35740216
http://dx.doi.org/10.3390/antibiotics11060810
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author Rashid, Md. Mahbubur
Akhtar, Zubair
Chowdhury, Sukanta
Islam, Md. Ariful
Parveen, Shahana
Ghosh, Probir Kumar
Rahman, Aninda
Khan, Zobaidul Haque
Islam, Khaleda
Debnath, Nitish
Rahman, Mahmudur
Chowdhury, Fahmida
author_facet Rashid, Md. Mahbubur
Akhtar, Zubair
Chowdhury, Sukanta
Islam, Md. Ariful
Parveen, Shahana
Ghosh, Probir Kumar
Rahman, Aninda
Khan, Zobaidul Haque
Islam, Khaleda
Debnath, Nitish
Rahman, Mahmudur
Chowdhury, Fahmida
author_sort Rashid, Md. Mahbubur
collection PubMed
description For supporting antibiotic stewardship interventions, the World Health Organization (WHO) classified antibiotics through the AWaRe (Access, Watch, and Reserve) classification. Inappropriate use of antimicrobials among hospital-admitted patients exposes them to the vulnerability of developing resistant organisms which are difficult to treat. We aimed to describe the proportion of antibiotic use based on the WHO AWaRe classification in tertiary and secondary level hospitals in Bangladesh. A point prevalence survey (PPS) was conducted adapting the WHO PPS design in inpatients departments in 2021. Among the 1417 enrolled patients, 52% were female and 63% were from the 15–64 years age group. Nearly 78% of patients received at least one antibiotic during the survey period. Third-generation cephalosporins (44.6%), penicillins (12.3%), imidazoles (11.8%), aminoglycosides (7.2%), and macrolides (5.8%) were documented as highly used antibiotics. Overall, 64.0% of Watch, 35.6% of Access, and 0.1% of Reserve group antibiotics were used for treatment. The use of Watch group antibiotics was high in medicine wards (78.7%) and overall high use of Watch antibiotics was observed at secondary hospitals (71.5%) compared to tertiary hospitals (60.2%) (p-value of 0.000). Our PPS findings underscore the need for an urgent nationwide antibiotic stewardship program for physicians including the development and implementation of local guidelines and in-service training on antibiotic use.
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spelling pubmed-92201192022-06-24 Pattern of Antibiotic Use among Hospitalized Patients according to WHO Access, Watch, Reserve (AWaRe) Classification: Findings from a Point Prevalence Survey in Bangladesh Rashid, Md. Mahbubur Akhtar, Zubair Chowdhury, Sukanta Islam, Md. Ariful Parveen, Shahana Ghosh, Probir Kumar Rahman, Aninda Khan, Zobaidul Haque Islam, Khaleda Debnath, Nitish Rahman, Mahmudur Chowdhury, Fahmida Antibiotics (Basel) Article For supporting antibiotic stewardship interventions, the World Health Organization (WHO) classified antibiotics through the AWaRe (Access, Watch, and Reserve) classification. Inappropriate use of antimicrobials among hospital-admitted patients exposes them to the vulnerability of developing resistant organisms which are difficult to treat. We aimed to describe the proportion of antibiotic use based on the WHO AWaRe classification in tertiary and secondary level hospitals in Bangladesh. A point prevalence survey (PPS) was conducted adapting the WHO PPS design in inpatients departments in 2021. Among the 1417 enrolled patients, 52% were female and 63% were from the 15–64 years age group. Nearly 78% of patients received at least one antibiotic during the survey period. Third-generation cephalosporins (44.6%), penicillins (12.3%), imidazoles (11.8%), aminoglycosides (7.2%), and macrolides (5.8%) were documented as highly used antibiotics. Overall, 64.0% of Watch, 35.6% of Access, and 0.1% of Reserve group antibiotics were used for treatment. The use of Watch group antibiotics was high in medicine wards (78.7%) and overall high use of Watch antibiotics was observed at secondary hospitals (71.5%) compared to tertiary hospitals (60.2%) (p-value of 0.000). Our PPS findings underscore the need for an urgent nationwide antibiotic stewardship program for physicians including the development and implementation of local guidelines and in-service training on antibiotic use. MDPI 2022-06-16 /pmc/articles/PMC9220119/ /pubmed/35740216 http://dx.doi.org/10.3390/antibiotics11060810 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Rashid, Md. Mahbubur
Akhtar, Zubair
Chowdhury, Sukanta
Islam, Md. Ariful
Parveen, Shahana
Ghosh, Probir Kumar
Rahman, Aninda
Khan, Zobaidul Haque
Islam, Khaleda
Debnath, Nitish
Rahman, Mahmudur
Chowdhury, Fahmida
Pattern of Antibiotic Use among Hospitalized Patients according to WHO Access, Watch, Reserve (AWaRe) Classification: Findings from a Point Prevalence Survey in Bangladesh
title Pattern of Antibiotic Use among Hospitalized Patients according to WHO Access, Watch, Reserve (AWaRe) Classification: Findings from a Point Prevalence Survey in Bangladesh
title_full Pattern of Antibiotic Use among Hospitalized Patients according to WHO Access, Watch, Reserve (AWaRe) Classification: Findings from a Point Prevalence Survey in Bangladesh
title_fullStr Pattern of Antibiotic Use among Hospitalized Patients according to WHO Access, Watch, Reserve (AWaRe) Classification: Findings from a Point Prevalence Survey in Bangladesh
title_full_unstemmed Pattern of Antibiotic Use among Hospitalized Patients according to WHO Access, Watch, Reserve (AWaRe) Classification: Findings from a Point Prevalence Survey in Bangladesh
title_short Pattern of Antibiotic Use among Hospitalized Patients according to WHO Access, Watch, Reserve (AWaRe) Classification: Findings from a Point Prevalence Survey in Bangladesh
title_sort pattern of antibiotic use among hospitalized patients according to who access, watch, reserve (aware) classification: findings from a point prevalence survey in bangladesh
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9220119/
https://www.ncbi.nlm.nih.gov/pubmed/35740216
http://dx.doi.org/10.3390/antibiotics11060810
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