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Male Knock-in Mice Expressing an Arachidonic Acid Lipoxygenase 15B (Alox15B) with Humanized Reaction Specificity Are Prematurely Growth Arrested When Aging

Mammalian arachidonic acid lipoxygenases (ALOXs) have been implicated in cell differentiation and in the pathogenesis of inflammation. The mouse genome involves seven functional Alox genes and the encoded enzymes share a high degree of amino acid conservation with their human orthologs. There are, h...

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Detalles Bibliográficos
Autores principales:	Schäfer, Marjann, Kakularam, Kumar R., Reisch, Florian, Rothe, Michael, Stehling, Sabine, Heydeck, Dagmar, Püschel, Gerhard P., Kuhn, Hartmut
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9220125/ https://www.ncbi.nlm.nih.gov/pubmed/35740398 http://dx.doi.org/10.3390/biomedicines10061379

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