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Mitochondrial Quality Control in the Heart: The Balance between Physiological and Pathological Stress

Alterations in mitochondrial function and morphology are critical adaptations to cardiovascular stress, working in concert in an attempt to restore organelle-level and cellular-level homeostasis. Processes that alter mitochondrial morphology include fission, fusion, mitophagy, and biogenesis, and th...

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Detalles Bibliográficos
Autores principales: Fajardo, Giovanni, Coronado, Michael, Matthews, Melia, Bernstein, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9220167/
https://www.ncbi.nlm.nih.gov/pubmed/35740401
http://dx.doi.org/10.3390/biomedicines10061375
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author Fajardo, Giovanni
Coronado, Michael
Matthews, Melia
Bernstein, Daniel
author_facet Fajardo, Giovanni
Coronado, Michael
Matthews, Melia
Bernstein, Daniel
author_sort Fajardo, Giovanni
collection PubMed
description Alterations in mitochondrial function and morphology are critical adaptations to cardiovascular stress, working in concert in an attempt to restore organelle-level and cellular-level homeostasis. Processes that alter mitochondrial morphology include fission, fusion, mitophagy, and biogenesis, and these interact to maintain mitochondrial quality control. Not all cardiovascular stress is pathologic (e.g., ischemia, pressure overload, cardiotoxins), despite a wealth of studies to this effect. Physiological stress, such as that induced by aerobic exercise, can induce morphologic adaptations that share many common pathways with pathological stress, but in this case result in improved mitochondrial health. Developing a better understanding of the mechanisms underlying alterations in mitochondrial quality control under diverse cardiovascular stressors will aid in the development of pharmacologic interventions aimed at restoring cellular homeostasis.
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spelling pubmed-92201672022-06-24 Mitochondrial Quality Control in the Heart: The Balance between Physiological and Pathological Stress Fajardo, Giovanni Coronado, Michael Matthews, Melia Bernstein, Daniel Biomedicines Review Alterations in mitochondrial function and morphology are critical adaptations to cardiovascular stress, working in concert in an attempt to restore organelle-level and cellular-level homeostasis. Processes that alter mitochondrial morphology include fission, fusion, mitophagy, and biogenesis, and these interact to maintain mitochondrial quality control. Not all cardiovascular stress is pathologic (e.g., ischemia, pressure overload, cardiotoxins), despite a wealth of studies to this effect. Physiological stress, such as that induced by aerobic exercise, can induce morphologic adaptations that share many common pathways with pathological stress, but in this case result in improved mitochondrial health. Developing a better understanding of the mechanisms underlying alterations in mitochondrial quality control under diverse cardiovascular stressors will aid in the development of pharmacologic interventions aimed at restoring cellular homeostasis. MDPI 2022-06-10 /pmc/articles/PMC9220167/ /pubmed/35740401 http://dx.doi.org/10.3390/biomedicines10061375 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Fajardo, Giovanni
Coronado, Michael
Matthews, Melia
Bernstein, Daniel
Mitochondrial Quality Control in the Heart: The Balance between Physiological and Pathological Stress
title Mitochondrial Quality Control in the Heart: The Balance between Physiological and Pathological Stress
title_full Mitochondrial Quality Control in the Heart: The Balance between Physiological and Pathological Stress
title_fullStr Mitochondrial Quality Control in the Heart: The Balance between Physiological and Pathological Stress
title_full_unstemmed Mitochondrial Quality Control in the Heart: The Balance between Physiological and Pathological Stress
title_short Mitochondrial Quality Control in the Heart: The Balance between Physiological and Pathological Stress
title_sort mitochondrial quality control in the heart: the balance between physiological and pathological stress
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9220167/
https://www.ncbi.nlm.nih.gov/pubmed/35740401
http://dx.doi.org/10.3390/biomedicines10061375
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