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Mitochondrial Quality Control in the Heart: The Balance between Physiological and Pathological Stress
Alterations in mitochondrial function and morphology are critical adaptations to cardiovascular stress, working in concert in an attempt to restore organelle-level and cellular-level homeostasis. Processes that alter mitochondrial morphology include fission, fusion, mitophagy, and biogenesis, and th...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9220167/ https://www.ncbi.nlm.nih.gov/pubmed/35740401 http://dx.doi.org/10.3390/biomedicines10061375 |
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author | Fajardo, Giovanni Coronado, Michael Matthews, Melia Bernstein, Daniel |
author_facet | Fajardo, Giovanni Coronado, Michael Matthews, Melia Bernstein, Daniel |
author_sort | Fajardo, Giovanni |
collection | PubMed |
description | Alterations in mitochondrial function and morphology are critical adaptations to cardiovascular stress, working in concert in an attempt to restore organelle-level and cellular-level homeostasis. Processes that alter mitochondrial morphology include fission, fusion, mitophagy, and biogenesis, and these interact to maintain mitochondrial quality control. Not all cardiovascular stress is pathologic (e.g., ischemia, pressure overload, cardiotoxins), despite a wealth of studies to this effect. Physiological stress, such as that induced by aerobic exercise, can induce morphologic adaptations that share many common pathways with pathological stress, but in this case result in improved mitochondrial health. Developing a better understanding of the mechanisms underlying alterations in mitochondrial quality control under diverse cardiovascular stressors will aid in the development of pharmacologic interventions aimed at restoring cellular homeostasis. |
format | Online Article Text |
id | pubmed-9220167 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-92201672022-06-24 Mitochondrial Quality Control in the Heart: The Balance between Physiological and Pathological Stress Fajardo, Giovanni Coronado, Michael Matthews, Melia Bernstein, Daniel Biomedicines Review Alterations in mitochondrial function and morphology are critical adaptations to cardiovascular stress, working in concert in an attempt to restore organelle-level and cellular-level homeostasis. Processes that alter mitochondrial morphology include fission, fusion, mitophagy, and biogenesis, and these interact to maintain mitochondrial quality control. Not all cardiovascular stress is pathologic (e.g., ischemia, pressure overload, cardiotoxins), despite a wealth of studies to this effect. Physiological stress, such as that induced by aerobic exercise, can induce morphologic adaptations that share many common pathways with pathological stress, but in this case result in improved mitochondrial health. Developing a better understanding of the mechanisms underlying alterations in mitochondrial quality control under diverse cardiovascular stressors will aid in the development of pharmacologic interventions aimed at restoring cellular homeostasis. MDPI 2022-06-10 /pmc/articles/PMC9220167/ /pubmed/35740401 http://dx.doi.org/10.3390/biomedicines10061375 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Fajardo, Giovanni Coronado, Michael Matthews, Melia Bernstein, Daniel Mitochondrial Quality Control in the Heart: The Balance between Physiological and Pathological Stress |
title | Mitochondrial Quality Control in the Heart: The Balance between Physiological and Pathological Stress |
title_full | Mitochondrial Quality Control in the Heart: The Balance between Physiological and Pathological Stress |
title_fullStr | Mitochondrial Quality Control in the Heart: The Balance between Physiological and Pathological Stress |
title_full_unstemmed | Mitochondrial Quality Control in the Heart: The Balance between Physiological and Pathological Stress |
title_short | Mitochondrial Quality Control in the Heart: The Balance between Physiological and Pathological Stress |
title_sort | mitochondrial quality control in the heart: the balance between physiological and pathological stress |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9220167/ https://www.ncbi.nlm.nih.gov/pubmed/35740401 http://dx.doi.org/10.3390/biomedicines10061375 |
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