Cargando…
Contribution of Tumor-Derived Extracellular Vesicles to Malignant Transformation of Normal Cells
Tumor-cell-derived extracellular vesicles (EVs) are known to carry biologically active molecules of parental cells, which can actively modulate the tumor microenvironment. EVs produced by tumor cells play significant roles in the development and maintenance of tumor growth, metastasis, immune escape...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9220176/ https://www.ncbi.nlm.nih.gov/pubmed/35735488 http://dx.doi.org/10.3390/bioengineering9060245 |
_version_ | 1784732308349124608 |
---|---|
author | Chulpanova, Daria S. Pukhalskaia, Tamara V. Rizvanov, Albert A. Solovyeva, Valeriya V. |
author_facet | Chulpanova, Daria S. Pukhalskaia, Tamara V. Rizvanov, Albert A. Solovyeva, Valeriya V. |
author_sort | Chulpanova, Daria S. |
collection | PubMed |
description | Tumor-cell-derived extracellular vesicles (EVs) are known to carry biologically active molecules of parental cells, which can actively modulate the tumor microenvironment. EVs produced by tumor cells play significant roles in the development and maintenance of tumor growth, metastasis, immune escape, and other important processes. However, the ability of EVs to induce the transformation of normal cells has hardly been investigated. This review discusses studies that describe the ability of tumor-cell-derived EVs to alter the metabolism and morphology of normal cells, causing changes associated with malignant transformation. Additionally, the horizontal transfer of oncogenes through EVs of tumor cells and the induction of epigenetic changes in normal cells, which leads to genomic instability and subsequent oncogenic transformation of normal cells, are also discussed. |
format | Online Article Text |
id | pubmed-9220176 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-92201762022-06-24 Contribution of Tumor-Derived Extracellular Vesicles to Malignant Transformation of Normal Cells Chulpanova, Daria S. Pukhalskaia, Tamara V. Rizvanov, Albert A. Solovyeva, Valeriya V. Bioengineering (Basel) Review Tumor-cell-derived extracellular vesicles (EVs) are known to carry biologically active molecules of parental cells, which can actively modulate the tumor microenvironment. EVs produced by tumor cells play significant roles in the development and maintenance of tumor growth, metastasis, immune escape, and other important processes. However, the ability of EVs to induce the transformation of normal cells has hardly been investigated. This review discusses studies that describe the ability of tumor-cell-derived EVs to alter the metabolism and morphology of normal cells, causing changes associated with malignant transformation. Additionally, the horizontal transfer of oncogenes through EVs of tumor cells and the induction of epigenetic changes in normal cells, which leads to genomic instability and subsequent oncogenic transformation of normal cells, are also discussed. MDPI 2022-06-04 /pmc/articles/PMC9220176/ /pubmed/35735488 http://dx.doi.org/10.3390/bioengineering9060245 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Chulpanova, Daria S. Pukhalskaia, Tamara V. Rizvanov, Albert A. Solovyeva, Valeriya V. Contribution of Tumor-Derived Extracellular Vesicles to Malignant Transformation of Normal Cells |
title | Contribution of Tumor-Derived Extracellular Vesicles to Malignant Transformation of Normal Cells |
title_full | Contribution of Tumor-Derived Extracellular Vesicles to Malignant Transformation of Normal Cells |
title_fullStr | Contribution of Tumor-Derived Extracellular Vesicles to Malignant Transformation of Normal Cells |
title_full_unstemmed | Contribution of Tumor-Derived Extracellular Vesicles to Malignant Transformation of Normal Cells |
title_short | Contribution of Tumor-Derived Extracellular Vesicles to Malignant Transformation of Normal Cells |
title_sort | contribution of tumor-derived extracellular vesicles to malignant transformation of normal cells |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9220176/ https://www.ncbi.nlm.nih.gov/pubmed/35735488 http://dx.doi.org/10.3390/bioengineering9060245 |
work_keys_str_mv | AT chulpanovadarias contributionoftumorderivedextracellularvesiclestomalignanttransformationofnormalcells AT pukhalskaiatamarav contributionoftumorderivedextracellularvesiclestomalignanttransformationofnormalcells AT rizvanovalberta contributionoftumorderivedextracellularvesiclestomalignanttransformationofnormalcells AT solovyevavaleriyav contributionoftumorderivedextracellularvesiclestomalignanttransformationofnormalcells |