Cargando…

Contribution of Tumor-Derived Extracellular Vesicles to Malignant Transformation of Normal Cells

Tumor-cell-derived extracellular vesicles (EVs) are known to carry biologically active molecules of parental cells, which can actively modulate the tumor microenvironment. EVs produced by tumor cells play significant roles in the development and maintenance of tumor growth, metastasis, immune escape...

Descripción completa

Detalles Bibliográficos
Autores principales: Chulpanova, Daria S., Pukhalskaia, Tamara V., Rizvanov, Albert A., Solovyeva, Valeriya V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9220176/
https://www.ncbi.nlm.nih.gov/pubmed/35735488
http://dx.doi.org/10.3390/bioengineering9060245
_version_ 1784732308349124608
author Chulpanova, Daria S.
Pukhalskaia, Tamara V.
Rizvanov, Albert A.
Solovyeva, Valeriya V.
author_facet Chulpanova, Daria S.
Pukhalskaia, Tamara V.
Rizvanov, Albert A.
Solovyeva, Valeriya V.
author_sort Chulpanova, Daria S.
collection PubMed
description Tumor-cell-derived extracellular vesicles (EVs) are known to carry biologically active molecules of parental cells, which can actively modulate the tumor microenvironment. EVs produced by tumor cells play significant roles in the development and maintenance of tumor growth, metastasis, immune escape, and other important processes. However, the ability of EVs to induce the transformation of normal cells has hardly been investigated. This review discusses studies that describe the ability of tumor-cell-derived EVs to alter the metabolism and morphology of normal cells, causing changes associated with malignant transformation. Additionally, the horizontal transfer of oncogenes through EVs of tumor cells and the induction of epigenetic changes in normal cells, which leads to genomic instability and subsequent oncogenic transformation of normal cells, are also discussed.
format Online
Article
Text
id pubmed-9220176
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-92201762022-06-24 Contribution of Tumor-Derived Extracellular Vesicles to Malignant Transformation of Normal Cells Chulpanova, Daria S. Pukhalskaia, Tamara V. Rizvanov, Albert A. Solovyeva, Valeriya V. Bioengineering (Basel) Review Tumor-cell-derived extracellular vesicles (EVs) are known to carry biologically active molecules of parental cells, which can actively modulate the tumor microenvironment. EVs produced by tumor cells play significant roles in the development and maintenance of tumor growth, metastasis, immune escape, and other important processes. However, the ability of EVs to induce the transformation of normal cells has hardly been investigated. This review discusses studies that describe the ability of tumor-cell-derived EVs to alter the metabolism and morphology of normal cells, causing changes associated with malignant transformation. Additionally, the horizontal transfer of oncogenes through EVs of tumor cells and the induction of epigenetic changes in normal cells, which leads to genomic instability and subsequent oncogenic transformation of normal cells, are also discussed. MDPI 2022-06-04 /pmc/articles/PMC9220176/ /pubmed/35735488 http://dx.doi.org/10.3390/bioengineering9060245 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Chulpanova, Daria S.
Pukhalskaia, Tamara V.
Rizvanov, Albert A.
Solovyeva, Valeriya V.
Contribution of Tumor-Derived Extracellular Vesicles to Malignant Transformation of Normal Cells
title Contribution of Tumor-Derived Extracellular Vesicles to Malignant Transformation of Normal Cells
title_full Contribution of Tumor-Derived Extracellular Vesicles to Malignant Transformation of Normal Cells
title_fullStr Contribution of Tumor-Derived Extracellular Vesicles to Malignant Transformation of Normal Cells
title_full_unstemmed Contribution of Tumor-Derived Extracellular Vesicles to Malignant Transformation of Normal Cells
title_short Contribution of Tumor-Derived Extracellular Vesicles to Malignant Transformation of Normal Cells
title_sort contribution of tumor-derived extracellular vesicles to malignant transformation of normal cells
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9220176/
https://www.ncbi.nlm.nih.gov/pubmed/35735488
http://dx.doi.org/10.3390/bioengineering9060245
work_keys_str_mv AT chulpanovadarias contributionoftumorderivedextracellularvesiclestomalignanttransformationofnormalcells
AT pukhalskaiatamarav contributionoftumorderivedextracellularvesiclestomalignanttransformationofnormalcells
AT rizvanovalberta contributionoftumorderivedextracellularvesiclestomalignanttransformationofnormalcells
AT solovyevavaleriyav contributionoftumorderivedextracellularvesiclestomalignanttransformationofnormalcells