High-Risk Acute Myeloid Leukemia: A Pediatric Prospective

Pediatric acute myeloid leukemia is a clonal disorder characterized by malignant transformation of the hematopoietic stem cell. The incidence and the outcome remain inferior when compared to pediatric ALL, although prognosis has improved in the last decades, with 80% overall survival rate reported i...

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Autores principales: Cacace, Fabiana, Iula, Rossella, De Novellis, Danilo, Caprioli, Valeria, D’Amico, Maria Rosaria, De Simone, Giuseppina, Cuccurullo, Rosanna, Wierda, William G., Mahadeo, Kris Michael, Menna, Giuseppe, Tambaro, Francesco Paolo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9220202/
https://www.ncbi.nlm.nih.gov/pubmed/35740427
http://dx.doi.org/10.3390/biomedicines10061405
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author Cacace, Fabiana
Iula, Rossella
De Novellis, Danilo
Caprioli, Valeria
D’Amico, Maria Rosaria
De Simone, Giuseppina
Cuccurullo, Rosanna
Wierda, William G.
Mahadeo, Kris Michael
Menna, Giuseppe
Tambaro, Francesco Paolo
author_facet Cacace, Fabiana
Iula, Rossella
De Novellis, Danilo
Caprioli, Valeria
D’Amico, Maria Rosaria
De Simone, Giuseppina
Cuccurullo, Rosanna
Wierda, William G.
Mahadeo, Kris Michael
Menna, Giuseppe
Tambaro, Francesco Paolo
author_sort Cacace, Fabiana
collection PubMed
description Pediatric acute myeloid leukemia is a clonal disorder characterized by malignant transformation of the hematopoietic stem cell. The incidence and the outcome remain inferior when compared to pediatric ALL, although prognosis has improved in the last decades, with 80% overall survival rate reported in some studies. The standard therapeutic approach is a combined cytarabine and anthracycline-based regimen followed by consolidation with allogeneic stem cell transplantation (allo-SCT) for high-risk AML and allo-SCT for non-high-risk patients only in second complete remission after relapse. In the last decade, several drugs have been used in clinical trials to improve outcomes in pediatric AML treatment.
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spelling pubmed-92202022022-06-24 High-Risk Acute Myeloid Leukemia: A Pediatric Prospective Cacace, Fabiana Iula, Rossella De Novellis, Danilo Caprioli, Valeria D’Amico, Maria Rosaria De Simone, Giuseppina Cuccurullo, Rosanna Wierda, William G. Mahadeo, Kris Michael Menna, Giuseppe Tambaro, Francesco Paolo Biomedicines Review Pediatric acute myeloid leukemia is a clonal disorder characterized by malignant transformation of the hematopoietic stem cell. The incidence and the outcome remain inferior when compared to pediatric ALL, although prognosis has improved in the last decades, with 80% overall survival rate reported in some studies. The standard therapeutic approach is a combined cytarabine and anthracycline-based regimen followed by consolidation with allogeneic stem cell transplantation (allo-SCT) for high-risk AML and allo-SCT for non-high-risk patients only in second complete remission after relapse. In the last decade, several drugs have been used in clinical trials to improve outcomes in pediatric AML treatment. MDPI 2022-06-14 /pmc/articles/PMC9220202/ /pubmed/35740427 http://dx.doi.org/10.3390/biomedicines10061405 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Cacace, Fabiana
Iula, Rossella
De Novellis, Danilo
Caprioli, Valeria
D’Amico, Maria Rosaria
De Simone, Giuseppina
Cuccurullo, Rosanna
Wierda, William G.
Mahadeo, Kris Michael
Menna, Giuseppe
Tambaro, Francesco Paolo
High-Risk Acute Myeloid Leukemia: A Pediatric Prospective
title High-Risk Acute Myeloid Leukemia: A Pediatric Prospective
title_full High-Risk Acute Myeloid Leukemia: A Pediatric Prospective
title_fullStr High-Risk Acute Myeloid Leukemia: A Pediatric Prospective
title_full_unstemmed High-Risk Acute Myeloid Leukemia: A Pediatric Prospective
title_short High-Risk Acute Myeloid Leukemia: A Pediatric Prospective
title_sort high-risk acute myeloid leukemia: a pediatric prospective
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9220202/
https://www.ncbi.nlm.nih.gov/pubmed/35740427
http://dx.doi.org/10.3390/biomedicines10061405
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