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Fingertip-Measured Skin Carotenoids and Advanced Glycation End Product Levels in Glaucoma
Carotenoids have antioxidant properties, and the accumulation of advanced glycation end products (AGEs) is associated with reactive oxygen species production; they have attracted attention as factors predictive of the onset and progression in glaucoma. Fingertip measurement is applicable for caroten...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9220224/ https://www.ncbi.nlm.nih.gov/pubmed/35740035 http://dx.doi.org/10.3390/antiox11061138 |
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author | Kadoh, Yoichi Takayanagi, Yuji Sasaki, Junichi Tanito, Masaki |
author_facet | Kadoh, Yoichi Takayanagi, Yuji Sasaki, Junichi Tanito, Masaki |
author_sort | Kadoh, Yoichi |
collection | PubMed |
description | Carotenoids have antioxidant properties, and the accumulation of advanced glycation end products (AGEs) is associated with reactive oxygen species production; they have attracted attention as factors predictive of the onset and progression in glaucoma. Fingertip measurement is applicable for carotenoids and AGEs due to its noninvasiveness and simplicity. The study included 663 eyes of 663 Japanese subjects (357 males, 306 females). The mean age was 69.9 years with a standard deviation of 11.0. The study population comprised participants with primary open-angle glaucoma (PG) (n = 358), exfoliation glaucoma (EG) (n = 168), and controls (n = 137). Multivariate models suggested that lower skin carotenoid (SC) levels were associated with male gender (standard β = −0.14), AGE scores (−0.24), and a history of intraocular surgery (−0.22). Higher SC levels were associated with higher vegetable intake scores (0.21 for score 3) and diabetes (0.10). However, no association was seen between SCs and glaucoma type. AGEs levels were negatively associated with carotenoid scores (−0.25), PG (−0.15), and smoking habits (−0.26) and positively correlated with EG (0.14). SCs and AGEs were negatively correlated in the single regression analysis (r = −0.20, p < 0.0001). In conclusion, higher levels of AGEs may be candidates for systemic biomarkers of glaucoma associated with the exfoliation syndrome. SC levels can reflect self-reported daily vegetable intake. |
format | Online Article Text |
id | pubmed-9220224 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-92202242022-06-24 Fingertip-Measured Skin Carotenoids and Advanced Glycation End Product Levels in Glaucoma Kadoh, Yoichi Takayanagi, Yuji Sasaki, Junichi Tanito, Masaki Antioxidants (Basel) Article Carotenoids have antioxidant properties, and the accumulation of advanced glycation end products (AGEs) is associated with reactive oxygen species production; they have attracted attention as factors predictive of the onset and progression in glaucoma. Fingertip measurement is applicable for carotenoids and AGEs due to its noninvasiveness and simplicity. The study included 663 eyes of 663 Japanese subjects (357 males, 306 females). The mean age was 69.9 years with a standard deviation of 11.0. The study population comprised participants with primary open-angle glaucoma (PG) (n = 358), exfoliation glaucoma (EG) (n = 168), and controls (n = 137). Multivariate models suggested that lower skin carotenoid (SC) levels were associated with male gender (standard β = −0.14), AGE scores (−0.24), and a history of intraocular surgery (−0.22). Higher SC levels were associated with higher vegetable intake scores (0.21 for score 3) and diabetes (0.10). However, no association was seen between SCs and glaucoma type. AGEs levels were negatively associated with carotenoid scores (−0.25), PG (−0.15), and smoking habits (−0.26) and positively correlated with EG (0.14). SCs and AGEs were negatively correlated in the single regression analysis (r = −0.20, p < 0.0001). In conclusion, higher levels of AGEs may be candidates for systemic biomarkers of glaucoma associated with the exfoliation syndrome. SC levels can reflect self-reported daily vegetable intake. MDPI 2022-06-09 /pmc/articles/PMC9220224/ /pubmed/35740035 http://dx.doi.org/10.3390/antiox11061138 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Kadoh, Yoichi Takayanagi, Yuji Sasaki, Junichi Tanito, Masaki Fingertip-Measured Skin Carotenoids and Advanced Glycation End Product Levels in Glaucoma |
title | Fingertip-Measured Skin Carotenoids and Advanced Glycation End Product Levels in Glaucoma |
title_full | Fingertip-Measured Skin Carotenoids and Advanced Glycation End Product Levels in Glaucoma |
title_fullStr | Fingertip-Measured Skin Carotenoids and Advanced Glycation End Product Levels in Glaucoma |
title_full_unstemmed | Fingertip-Measured Skin Carotenoids and Advanced Glycation End Product Levels in Glaucoma |
title_short | Fingertip-Measured Skin Carotenoids and Advanced Glycation End Product Levels in Glaucoma |
title_sort | fingertip-measured skin carotenoids and advanced glycation end product levels in glaucoma |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9220224/ https://www.ncbi.nlm.nih.gov/pubmed/35740035 http://dx.doi.org/10.3390/antiox11061138 |
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