Cargando…
Isolated Gastric Metastases of Pancreatic Ductal Adenocarcinoma following Radical Resection—Impact of Endosonography-Guided Fine Needle Aspiration Tract Seeding
Background: Endosonography-guided fine needle aspiration biopsy (EUS-FNA)-associated metachronous gastric seeding metastases (GSM) of pancreatic ductal adenocarcinoma (PDAC) represent a serious condition with insufficient evidence. Methods: Retrospective analysis of PDAC resections with a curative-i...
Autores principales: | , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9220227/ https://www.ncbi.nlm.nih.gov/pubmed/35740414 http://dx.doi.org/10.3390/biomedicines10061392 |
_version_ | 1784732321229832192 |
---|---|
author | Loveček, Martin Skalický, Pavel Urban, Ondřej Tesaříková, Jana Kliment, Martin Psár, Róbert Švébišová, Hana Urban, Kateřina Mohelníková-Duchoňová, Beatrice Klos, Dušan Stašek, Martin |
author_facet | Loveček, Martin Skalický, Pavel Urban, Ondřej Tesaříková, Jana Kliment, Martin Psár, Róbert Švébišová, Hana Urban, Kateřina Mohelníková-Duchoňová, Beatrice Klos, Dušan Stašek, Martin |
author_sort | Loveček, Martin |
collection | PubMed |
description | Background: Endosonography-guided fine needle aspiration biopsy (EUS-FNA)-associated metachronous gastric seeding metastases (GSM) of pancreatic ductal adenocarcinoma (PDAC) represent a serious condition with insufficient evidence. Methods: Retrospective analysis of PDAC resections with a curative-intent, proven pathological diagnosis of PDAC, preoperative EUS-FNA and post-resection follow-up of at least 60 months. The systematic literature search of published data was used for the GSM growth evaluation using Pearson correlation and the linear regression analyses. Results: The inclusion criteria met 59/134 cases, 16 (27%) had retained needle tract (15 following distal pancreatectomy, 1 following pylorus-sparing head resection). In total, 3/16 cases (19%) developed identical solitary GSM (10–26th month following primary surgery) and were radically resected. A total of 30 published cases of PDAC GSM following EUS-FNA were identified. Lesion was resected in 20 distal pancreatectomy cases with complete information in 14 cases. A correlation between the metastasis size and time (r = 0.612) was proven. The regression coefficient b = 0.72 expresses the growth of 0.72 mm per month. Conclusions: The GSM represent a preventable and curable condition. A remarkably high number of GSM following EUS-FNA was identified, leading to follow-up recommendation of EUS-FNA sampled patients. Multimodal management (gastric resection, adjuvant chemotherapy) may prolong survival. |
format | Online Article Text |
id | pubmed-9220227 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-92202272022-06-24 Isolated Gastric Metastases of Pancreatic Ductal Adenocarcinoma following Radical Resection—Impact of Endosonography-Guided Fine Needle Aspiration Tract Seeding Loveček, Martin Skalický, Pavel Urban, Ondřej Tesaříková, Jana Kliment, Martin Psár, Róbert Švébišová, Hana Urban, Kateřina Mohelníková-Duchoňová, Beatrice Klos, Dušan Stašek, Martin Biomedicines Article Background: Endosonography-guided fine needle aspiration biopsy (EUS-FNA)-associated metachronous gastric seeding metastases (GSM) of pancreatic ductal adenocarcinoma (PDAC) represent a serious condition with insufficient evidence. Methods: Retrospective analysis of PDAC resections with a curative-intent, proven pathological diagnosis of PDAC, preoperative EUS-FNA and post-resection follow-up of at least 60 months. The systematic literature search of published data was used for the GSM growth evaluation using Pearson correlation and the linear regression analyses. Results: The inclusion criteria met 59/134 cases, 16 (27%) had retained needle tract (15 following distal pancreatectomy, 1 following pylorus-sparing head resection). In total, 3/16 cases (19%) developed identical solitary GSM (10–26th month following primary surgery) and were radically resected. A total of 30 published cases of PDAC GSM following EUS-FNA were identified. Lesion was resected in 20 distal pancreatectomy cases with complete information in 14 cases. A correlation between the metastasis size and time (r = 0.612) was proven. The regression coefficient b = 0.72 expresses the growth of 0.72 mm per month. Conclusions: The GSM represent a preventable and curable condition. A remarkably high number of GSM following EUS-FNA was identified, leading to follow-up recommendation of EUS-FNA sampled patients. Multimodal management (gastric resection, adjuvant chemotherapy) may prolong survival. MDPI 2022-06-12 /pmc/articles/PMC9220227/ /pubmed/35740414 http://dx.doi.org/10.3390/biomedicines10061392 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Loveček, Martin Skalický, Pavel Urban, Ondřej Tesaříková, Jana Kliment, Martin Psár, Róbert Švébišová, Hana Urban, Kateřina Mohelníková-Duchoňová, Beatrice Klos, Dušan Stašek, Martin Isolated Gastric Metastases of Pancreatic Ductal Adenocarcinoma following Radical Resection—Impact of Endosonography-Guided Fine Needle Aspiration Tract Seeding |
title | Isolated Gastric Metastases of Pancreatic Ductal Adenocarcinoma following Radical Resection—Impact of Endosonography-Guided Fine Needle Aspiration Tract Seeding |
title_full | Isolated Gastric Metastases of Pancreatic Ductal Adenocarcinoma following Radical Resection—Impact of Endosonography-Guided Fine Needle Aspiration Tract Seeding |
title_fullStr | Isolated Gastric Metastases of Pancreatic Ductal Adenocarcinoma following Radical Resection—Impact of Endosonography-Guided Fine Needle Aspiration Tract Seeding |
title_full_unstemmed | Isolated Gastric Metastases of Pancreatic Ductal Adenocarcinoma following Radical Resection—Impact of Endosonography-Guided Fine Needle Aspiration Tract Seeding |
title_short | Isolated Gastric Metastases of Pancreatic Ductal Adenocarcinoma following Radical Resection—Impact of Endosonography-Guided Fine Needle Aspiration Tract Seeding |
title_sort | isolated gastric metastases of pancreatic ductal adenocarcinoma following radical resection—impact of endosonography-guided fine needle aspiration tract seeding |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9220227/ https://www.ncbi.nlm.nih.gov/pubmed/35740414 http://dx.doi.org/10.3390/biomedicines10061392 |
work_keys_str_mv | AT lovecekmartin isolatedgastricmetastasesofpancreaticductaladenocarcinomafollowingradicalresectionimpactofendosonographyguidedfineneedleaspirationtractseeding AT skalickypavel isolatedgastricmetastasesofpancreaticductaladenocarcinomafollowingradicalresectionimpactofendosonographyguidedfineneedleaspirationtractseeding AT urbanondrej isolatedgastricmetastasesofpancreaticductaladenocarcinomafollowingradicalresectionimpactofendosonographyguidedfineneedleaspirationtractseeding AT tesarikovajana isolatedgastricmetastasesofpancreaticductaladenocarcinomafollowingradicalresectionimpactofendosonographyguidedfineneedleaspirationtractseeding AT klimentmartin isolatedgastricmetastasesofpancreaticductaladenocarcinomafollowingradicalresectionimpactofendosonographyguidedfineneedleaspirationtractseeding AT psarrobert isolatedgastricmetastasesofpancreaticductaladenocarcinomafollowingradicalresectionimpactofendosonographyguidedfineneedleaspirationtractseeding AT svebisovahana isolatedgastricmetastasesofpancreaticductaladenocarcinomafollowingradicalresectionimpactofendosonographyguidedfineneedleaspirationtractseeding AT urbankaterina isolatedgastricmetastasesofpancreaticductaladenocarcinomafollowingradicalresectionimpactofendosonographyguidedfineneedleaspirationtractseeding AT mohelnikovaduchonovabeatrice isolatedgastricmetastasesofpancreaticductaladenocarcinomafollowingradicalresectionimpactofendosonographyguidedfineneedleaspirationtractseeding AT klosdusan isolatedgastricmetastasesofpancreaticductaladenocarcinomafollowingradicalresectionimpactofendosonographyguidedfineneedleaspirationtractseeding AT stasekmartin isolatedgastricmetastasesofpancreaticductaladenocarcinomafollowingradicalresectionimpactofendosonographyguidedfineneedleaspirationtractseeding |