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Isolated Gastric Metastases of Pancreatic Ductal Adenocarcinoma following Radical Resection—Impact of Endosonography-Guided Fine Needle Aspiration Tract Seeding

Background: Endosonography-guided fine needle aspiration biopsy (EUS-FNA)-associated metachronous gastric seeding metastases (GSM) of pancreatic ductal adenocarcinoma (PDAC) represent a serious condition with insufficient evidence. Methods: Retrospective analysis of PDAC resections with a curative-i...

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Autores principales: Loveček, Martin, Skalický, Pavel, Urban, Ondřej, Tesaříková, Jana, Kliment, Martin, Psár, Róbert, Švébišová, Hana, Urban, Kateřina, Mohelníková-Duchoňová, Beatrice, Klos, Dušan, Stašek, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9220227/
https://www.ncbi.nlm.nih.gov/pubmed/35740414
http://dx.doi.org/10.3390/biomedicines10061392
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author Loveček, Martin
Skalický, Pavel
Urban, Ondřej
Tesaříková, Jana
Kliment, Martin
Psár, Róbert
Švébišová, Hana
Urban, Kateřina
Mohelníková-Duchoňová, Beatrice
Klos, Dušan
Stašek, Martin
author_facet Loveček, Martin
Skalický, Pavel
Urban, Ondřej
Tesaříková, Jana
Kliment, Martin
Psár, Róbert
Švébišová, Hana
Urban, Kateřina
Mohelníková-Duchoňová, Beatrice
Klos, Dušan
Stašek, Martin
author_sort Loveček, Martin
collection PubMed
description Background: Endosonography-guided fine needle aspiration biopsy (EUS-FNA)-associated metachronous gastric seeding metastases (GSM) of pancreatic ductal adenocarcinoma (PDAC) represent a serious condition with insufficient evidence. Methods: Retrospective analysis of PDAC resections with a curative-intent, proven pathological diagnosis of PDAC, preoperative EUS-FNA and post-resection follow-up of at least 60 months. The systematic literature search of published data was used for the GSM growth evaluation using Pearson correlation and the linear regression analyses. Results: The inclusion criteria met 59/134 cases, 16 (27%) had retained needle tract (15 following distal pancreatectomy, 1 following pylorus-sparing head resection). In total, 3/16 cases (19%) developed identical solitary GSM (10–26th month following primary surgery) and were radically resected. A total of 30 published cases of PDAC GSM following EUS-FNA were identified. Lesion was resected in 20 distal pancreatectomy cases with complete information in 14 cases. A correlation between the metastasis size and time (r = 0.612) was proven. The regression coefficient b = 0.72 expresses the growth of 0.72 mm per month. Conclusions: The GSM represent a preventable and curable condition. A remarkably high number of GSM following EUS-FNA was identified, leading to follow-up recommendation of EUS-FNA sampled patients. Multimodal management (gastric resection, adjuvant chemotherapy) may prolong survival.
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spelling pubmed-92202272022-06-24 Isolated Gastric Metastases of Pancreatic Ductal Adenocarcinoma following Radical Resection—Impact of Endosonography-Guided Fine Needle Aspiration Tract Seeding Loveček, Martin Skalický, Pavel Urban, Ondřej Tesaříková, Jana Kliment, Martin Psár, Róbert Švébišová, Hana Urban, Kateřina Mohelníková-Duchoňová, Beatrice Klos, Dušan Stašek, Martin Biomedicines Article Background: Endosonography-guided fine needle aspiration biopsy (EUS-FNA)-associated metachronous gastric seeding metastases (GSM) of pancreatic ductal adenocarcinoma (PDAC) represent a serious condition with insufficient evidence. Methods: Retrospective analysis of PDAC resections with a curative-intent, proven pathological diagnosis of PDAC, preoperative EUS-FNA and post-resection follow-up of at least 60 months. The systematic literature search of published data was used for the GSM growth evaluation using Pearson correlation and the linear regression analyses. Results: The inclusion criteria met 59/134 cases, 16 (27%) had retained needle tract (15 following distal pancreatectomy, 1 following pylorus-sparing head resection). In total, 3/16 cases (19%) developed identical solitary GSM (10–26th month following primary surgery) and were radically resected. A total of 30 published cases of PDAC GSM following EUS-FNA were identified. Lesion was resected in 20 distal pancreatectomy cases with complete information in 14 cases. A correlation between the metastasis size and time (r = 0.612) was proven. The regression coefficient b = 0.72 expresses the growth of 0.72 mm per month. Conclusions: The GSM represent a preventable and curable condition. A remarkably high number of GSM following EUS-FNA was identified, leading to follow-up recommendation of EUS-FNA sampled patients. Multimodal management (gastric resection, adjuvant chemotherapy) may prolong survival. MDPI 2022-06-12 /pmc/articles/PMC9220227/ /pubmed/35740414 http://dx.doi.org/10.3390/biomedicines10061392 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Loveček, Martin
Skalický, Pavel
Urban, Ondřej
Tesaříková, Jana
Kliment, Martin
Psár, Róbert
Švébišová, Hana
Urban, Kateřina
Mohelníková-Duchoňová, Beatrice
Klos, Dušan
Stašek, Martin
Isolated Gastric Metastases of Pancreatic Ductal Adenocarcinoma following Radical Resection—Impact of Endosonography-Guided Fine Needle Aspiration Tract Seeding
title Isolated Gastric Metastases of Pancreatic Ductal Adenocarcinoma following Radical Resection—Impact of Endosonography-Guided Fine Needle Aspiration Tract Seeding
title_full Isolated Gastric Metastases of Pancreatic Ductal Adenocarcinoma following Radical Resection—Impact of Endosonography-Guided Fine Needle Aspiration Tract Seeding
title_fullStr Isolated Gastric Metastases of Pancreatic Ductal Adenocarcinoma following Radical Resection—Impact of Endosonography-Guided Fine Needle Aspiration Tract Seeding
title_full_unstemmed Isolated Gastric Metastases of Pancreatic Ductal Adenocarcinoma following Radical Resection—Impact of Endosonography-Guided Fine Needle Aspiration Tract Seeding
title_short Isolated Gastric Metastases of Pancreatic Ductal Adenocarcinoma following Radical Resection—Impact of Endosonography-Guided Fine Needle Aspiration Tract Seeding
title_sort isolated gastric metastases of pancreatic ductal adenocarcinoma following radical resection—impact of endosonography-guided fine needle aspiration tract seeding
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9220227/
https://www.ncbi.nlm.nih.gov/pubmed/35740414
http://dx.doi.org/10.3390/biomedicines10061392
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