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Empirical Antibiotic Prescribing in Adult COVID-19 Inpatients over Two Years in Mexico

Background and Objectives: Empirical antibiotic prescribing in patients with coronavirus disease 2019 (COVID-19) has been common even though bacterial coinfections are infrequent. The overuse of antibacterial agents may accelerate the antibiotic resistance crisis. We aimed to evaluate factors predic...

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Autores principales: Murillo-Zamora, Efrén, Trujillo, Xóchitl, Huerta, Miguel, Mendoza-Cano, Oliver, Guzmán-Esquivel, José, Guzmán-Solórzano, José Alejandro, Ochoa-Castro, María Regina, Ortega-Macías, Alan Gabriel, Zepeda-Anaya, Andrea Lizeth, Ruiz-Montes de Oca, Valeria, Ríos-Silva, Mónica, Lugo-Radillo, Agustin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9220240/
https://www.ncbi.nlm.nih.gov/pubmed/35740170
http://dx.doi.org/10.3390/antibiotics11060764
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author Murillo-Zamora, Efrén
Trujillo, Xóchitl
Huerta, Miguel
Mendoza-Cano, Oliver
Guzmán-Esquivel, José
Guzmán-Solórzano, José Alejandro
Ochoa-Castro, María Regina
Ortega-Macías, Alan Gabriel
Zepeda-Anaya, Andrea Lizeth
Ruiz-Montes de Oca, Valeria
Ríos-Silva, Mónica
Lugo-Radillo, Agustin
author_facet Murillo-Zamora, Efrén
Trujillo, Xóchitl
Huerta, Miguel
Mendoza-Cano, Oliver
Guzmán-Esquivel, José
Guzmán-Solórzano, José Alejandro
Ochoa-Castro, María Regina
Ortega-Macías, Alan Gabriel
Zepeda-Anaya, Andrea Lizeth
Ruiz-Montes de Oca, Valeria
Ríos-Silva, Mónica
Lugo-Radillo, Agustin
author_sort Murillo-Zamora, Efrén
collection PubMed
description Background and Objectives: Empirical antibiotic prescribing in patients with coronavirus disease 2019 (COVID-19) has been common even though bacterial coinfections are infrequent. The overuse of antibacterial agents may accelerate the antibiotic resistance crisis. We aimed to evaluate factors predicting empirical antibiotic prescribing to adult COVID-19 inpatients over 2 years (March 2020–February 2021) in Mexico. Materials and Methods: A cross-sectional analysis of a nationwide cohort study was conducted. Hospitalized adults due to laboratory-confirmed COVID-19 were included (n = 214,171). Odds ratios (OR) and 95% confidence intervals (CI), computed by using logistic regression models, were used to evaluate factors predicting empirical antibiotic prescribing. Results: The overall frequency of antibiotic usage was 25.3%. In multiple analysis, the highest risk of antibiotic prescription was documented among patients with pneumonia at hospital admission (OR = 2.20, 95% CI 2.16–2.25). Male patients, those with chronic comorbidities (namely obesity and chronic kidney disease) and longer interval days from symptoms onset to healthcare seeking, were also more likely to receive these drugs. We also documented that, per each elapsed week during the study period, the odds of receiving antibiotic therapy decreased by about 2% (OR = 0.98, 95% CI 0.97–0.99). Conclusion: Our study identified COVID-19 populations at increased risk of receiving empirical antibiotic therapy during the first two years of the pandemic.
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spelling pubmed-92202402022-06-24 Empirical Antibiotic Prescribing in Adult COVID-19 Inpatients over Two Years in Mexico Murillo-Zamora, Efrén Trujillo, Xóchitl Huerta, Miguel Mendoza-Cano, Oliver Guzmán-Esquivel, José Guzmán-Solórzano, José Alejandro Ochoa-Castro, María Regina Ortega-Macías, Alan Gabriel Zepeda-Anaya, Andrea Lizeth Ruiz-Montes de Oca, Valeria Ríos-Silva, Mónica Lugo-Radillo, Agustin Antibiotics (Basel) Article Background and Objectives: Empirical antibiotic prescribing in patients with coronavirus disease 2019 (COVID-19) has been common even though bacterial coinfections are infrequent. The overuse of antibacterial agents may accelerate the antibiotic resistance crisis. We aimed to evaluate factors predicting empirical antibiotic prescribing to adult COVID-19 inpatients over 2 years (March 2020–February 2021) in Mexico. Materials and Methods: A cross-sectional analysis of a nationwide cohort study was conducted. Hospitalized adults due to laboratory-confirmed COVID-19 were included (n = 214,171). Odds ratios (OR) and 95% confidence intervals (CI), computed by using logistic regression models, were used to evaluate factors predicting empirical antibiotic prescribing. Results: The overall frequency of antibiotic usage was 25.3%. In multiple analysis, the highest risk of antibiotic prescription was documented among patients with pneumonia at hospital admission (OR = 2.20, 95% CI 2.16–2.25). Male patients, those with chronic comorbidities (namely obesity and chronic kidney disease) and longer interval days from symptoms onset to healthcare seeking, were also more likely to receive these drugs. We also documented that, per each elapsed week during the study period, the odds of receiving antibiotic therapy decreased by about 2% (OR = 0.98, 95% CI 0.97–0.99). Conclusion: Our study identified COVID-19 populations at increased risk of receiving empirical antibiotic therapy during the first two years of the pandemic. MDPI 2022-06-02 /pmc/articles/PMC9220240/ /pubmed/35740170 http://dx.doi.org/10.3390/antibiotics11060764 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Murillo-Zamora, Efrén
Trujillo, Xóchitl
Huerta, Miguel
Mendoza-Cano, Oliver
Guzmán-Esquivel, José
Guzmán-Solórzano, José Alejandro
Ochoa-Castro, María Regina
Ortega-Macías, Alan Gabriel
Zepeda-Anaya, Andrea Lizeth
Ruiz-Montes de Oca, Valeria
Ríos-Silva, Mónica
Lugo-Radillo, Agustin
Empirical Antibiotic Prescribing in Adult COVID-19 Inpatients over Two Years in Mexico
title Empirical Antibiotic Prescribing in Adult COVID-19 Inpatients over Two Years in Mexico
title_full Empirical Antibiotic Prescribing in Adult COVID-19 Inpatients over Two Years in Mexico
title_fullStr Empirical Antibiotic Prescribing in Adult COVID-19 Inpatients over Two Years in Mexico
title_full_unstemmed Empirical Antibiotic Prescribing in Adult COVID-19 Inpatients over Two Years in Mexico
title_short Empirical Antibiotic Prescribing in Adult COVID-19 Inpatients over Two Years in Mexico
title_sort empirical antibiotic prescribing in adult covid-19 inpatients over two years in mexico
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9220240/
https://www.ncbi.nlm.nih.gov/pubmed/35740170
http://dx.doi.org/10.3390/antibiotics11060764
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