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Local and Systemic Oxidative Stress Biomarkers for Male Infertility: The ORION Study

Infertility problems occur in around 10% of all couples worldwide, with male-factor infertility as the sole contributor in 20–30% of these cases. Oxidative stress (OS) is suggested to be associated with the pathophysiology of male infertility. In spermatozoa, OS can lead to damage to the cell membra...

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Autores principales: Bergsma, Anna T., Li, Hui Ting, Eliveld, Jitske, Bulthuis, Marian L. C., Hoek, Annemieke, van Goor, Harry, Bourgonje, Arno R., Cantineau, Astrid E. P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9220279/
https://www.ncbi.nlm.nih.gov/pubmed/35739942
http://dx.doi.org/10.3390/antiox11061045
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author Bergsma, Anna T.
Li, Hui Ting
Eliveld, Jitske
Bulthuis, Marian L. C.
Hoek, Annemieke
van Goor, Harry
Bourgonje, Arno R.
Cantineau, Astrid E. P.
author_facet Bergsma, Anna T.
Li, Hui Ting
Eliveld, Jitske
Bulthuis, Marian L. C.
Hoek, Annemieke
van Goor, Harry
Bourgonje, Arno R.
Cantineau, Astrid E. P.
author_sort Bergsma, Anna T.
collection PubMed
description Infertility problems occur in around 10% of all couples worldwide, with male-factor infertility as the sole contributor in 20–30% of these cases. Oxidative stress (OS) is suggested to be associated with the pathophysiology of male infertility. In spermatozoa, OS can lead to damage to the cell membrane, resulting in disruption of DNA integrity and a decrease in motility. Established biomarkers for OS include free thiols and malondialdehyde (MDA), both representing different components of the reactive species interactome (RSI). This exploratory study aimed to investigate seminal plasma-free thiol and MDA levels in relation to semen parameters as defined by the World Health Organization (WHO) to determine if these markers are adequate to define local OS status. Furthermore, this study investigated if there is a relation between systemic and local OS status by comparing seminal concentrations of free thiol (R-SH, sulfhydryl groups, representing the extracellular redox status) and MDA (lipid peroxidation product) levels to those measured in serum. Free thiol and MDA measurements in both serum and semen plasma were performed in 50 males (18–55 y) of couples seeking fertility treatment. A significant positive correlation was found between seminal plasma-free thiol levels and sperm concentration and progressive motility (r = 0.383, p = 0.008 and r = 0.333, p = 0.022, respectively). In addition, a significant positive correlation was found between MDA levels in seminal plasma and sperm concentration (r = 0.314, p = 0.031). This study supports that seminal plasma-free thiols may be promising as local OS biomarkers. No associations were observed between local and systemic OS biomarker concentrations.
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spelling pubmed-92202792022-06-24 Local and Systemic Oxidative Stress Biomarkers for Male Infertility: The ORION Study Bergsma, Anna T. Li, Hui Ting Eliveld, Jitske Bulthuis, Marian L. C. Hoek, Annemieke van Goor, Harry Bourgonje, Arno R. Cantineau, Astrid E. P. Antioxidants (Basel) Article Infertility problems occur in around 10% of all couples worldwide, with male-factor infertility as the sole contributor in 20–30% of these cases. Oxidative stress (OS) is suggested to be associated with the pathophysiology of male infertility. In spermatozoa, OS can lead to damage to the cell membrane, resulting in disruption of DNA integrity and a decrease in motility. Established biomarkers for OS include free thiols and malondialdehyde (MDA), both representing different components of the reactive species interactome (RSI). This exploratory study aimed to investigate seminal plasma-free thiol and MDA levels in relation to semen parameters as defined by the World Health Organization (WHO) to determine if these markers are adequate to define local OS status. Furthermore, this study investigated if there is a relation between systemic and local OS status by comparing seminal concentrations of free thiol (R-SH, sulfhydryl groups, representing the extracellular redox status) and MDA (lipid peroxidation product) levels to those measured in serum. Free thiol and MDA measurements in both serum and semen plasma were performed in 50 males (18–55 y) of couples seeking fertility treatment. A significant positive correlation was found between seminal plasma-free thiol levels and sperm concentration and progressive motility (r = 0.383, p = 0.008 and r = 0.333, p = 0.022, respectively). In addition, a significant positive correlation was found between MDA levels in seminal plasma and sperm concentration (r = 0.314, p = 0.031). This study supports that seminal plasma-free thiols may be promising as local OS biomarkers. No associations were observed between local and systemic OS biomarker concentrations. MDPI 2022-05-25 /pmc/articles/PMC9220279/ /pubmed/35739942 http://dx.doi.org/10.3390/antiox11061045 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Bergsma, Anna T.
Li, Hui Ting
Eliveld, Jitske
Bulthuis, Marian L. C.
Hoek, Annemieke
van Goor, Harry
Bourgonje, Arno R.
Cantineau, Astrid E. P.
Local and Systemic Oxidative Stress Biomarkers for Male Infertility: The ORION Study
title Local and Systemic Oxidative Stress Biomarkers for Male Infertility: The ORION Study
title_full Local and Systemic Oxidative Stress Biomarkers for Male Infertility: The ORION Study
title_fullStr Local and Systemic Oxidative Stress Biomarkers for Male Infertility: The ORION Study
title_full_unstemmed Local and Systemic Oxidative Stress Biomarkers for Male Infertility: The ORION Study
title_short Local and Systemic Oxidative Stress Biomarkers for Male Infertility: The ORION Study
title_sort local and systemic oxidative stress biomarkers for male infertility: the orion study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9220279/
https://www.ncbi.nlm.nih.gov/pubmed/35739942
http://dx.doi.org/10.3390/antiox11061045
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