Indoleamine 2,3-dioxygenase 1 activation in mature cDC1 promotes tolerogenic education of inflammatory cDC2 via metabolic communication

Conventional dendritic cells (cDCs), cDC1 and cDC2, act both to initiate immunity and maintain self-tolerance. The tryptophan metabolic enzyme indoleamine 2,3-dioxygenase 1 (IDO1) is used by cDCs in maintaining tolerance, but its role in different subsets remains unclear. At homeostasis, only mature...

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Detalles Bibliográficos
Autores principales: Gargaro, Marco, Scalisi, Giulia, Manni, Giorgia, Briseño, Carlos G., Bagadia, Prachi, Durai, Vivek, Theisen, Derek J., Kim, Sunkyung, Castelli, Marilena, Xu, Chenling A., zu Hörste, Gerd Meyer, Servillo, Giuseppe, Della Fazia, Maria A., Mencarelli, Giulia, Ricciuti, Doriana, Padiglioni, Eleonora, Giacchè, Nicola, Colliva, Carolina, Pellicciari, Roberto, Calvitti, Mario, Zelante, Teresa, Fuchs, Dietmar, Orabona, Ciriana, Boon, Louis, Bessede, Alban, Colonna, Marco, Puccetti, Paolo, Murphy, Theresa L., Murphy, Kenneth M., Fallarino, Francesca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9220322/
https://www.ncbi.nlm.nih.gov/pubmed/35704993
http://dx.doi.org/10.1016/j.immuni.2022.05.013

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