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Evaluating the Impact of gRNA SNPs in CasRx Activity for Reducing Viral RNA in HCoV-OC43

Viruses within a given family often share common essential genes that are highly conserved due to their critical role for the virus’s replication and survival. In this work, we developed a proof-of-concept for a pan-coronavirus CRISPR effector system by designing CRISPR targets that are cross-reacti...

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Detalles Bibliográficos
Autores principales: Mayes, Cathryn Michelle, Santarpia, Joshua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9220780/
https://www.ncbi.nlm.nih.gov/pubmed/35740988
http://dx.doi.org/10.3390/cells11121859

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