Response to supraphysiological testosterone is predicted by a distinct androgen receptor cistrome

The androgen receptor (AR) is a master transcription factor that regulates prostate cancer (PC) development and progression. Inhibition of AR signaling by androgen deprivation is the first-line therapy with initial efficacy for advanced and recurrent PC. Paradoxically, supraphysiological levels of t...

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Detalles Bibliográficos
Autores principales: Qiu, Xintao, Brown, Lisha G., Conner, Jennifer L., Nguyen, Holly M., Boufaied, Nadia, Abou Alaiwi, Sarah, Seo, Ji-Heui, El Zarif, Talal, Bell, Connor, O’Connor, Edward, Hanratty, Brian, Pomerantz, Mark, Freedman, Matthew L., Brown, Myles, Haffner, Michael C., Nelson, Peter S., Feng, Felix Y., Labbé, David P., Long, Henry W., Corey, Eva
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Resource and Technical Advance
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9220831/
https://www.ncbi.nlm.nih.gov/pubmed/35603787
http://dx.doi.org/10.1172/jci.insight.157164

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