Targeting IL-1β as an immunopreventive and therapeutic modality for K-ras–mutant lung cancer

K-ras–mutant lung adenocarcinoma (KM-LUAD) is associated with abysmal prognosis and is tightly linked to tumor-promoting inflammation. A human mAb, canakinumab, targeting the proinflammatory cytokine IL-1β, significantly decreased the risk of lung cancer in the Canakinumab Anti-inflammatory Thrombos...

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Detalles Bibliográficos
Autores principales: Yuan, Bo, Clowers, Michael J., Velasco, Walter V., Peng, Stephen, Peng, Qian, Shi, Yewen, Ramos-Castaneda, Marco, Zarghooni, Melody, Yang, Shuanying, Babcock, Rachel L., Chang, Seon Hee, Heymach, John V., Zhang, Jianjun, Ostrin, Edwin J., Watowich, Stephanie S., Kadara, Humam, Moghaddam, Seyed Javad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9220853/
https://www.ncbi.nlm.nih.gov/pubmed/35471938
http://dx.doi.org/10.1172/jci.insight.157788

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