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Deep Brain Stimulation in Early-Stage Parkinson’s Disease: Patient Experience after 11 Years

The deep brain stimulation (DBS) in early-stage Parkinson’s disease (PD) pilot trial began more than a decade ago and remains the only investigation of DBS in mildly symptomatic patients. Patients completed therapeutic washouts biannually for two years, outpatient assessments through five years, and...

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Autores principales: Stoehr, Kaitlyn, Pazira, Kian, Bonnet, Kemberlee, Schlundt, David, Charles, David, Hacker, Mallory
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9220916/
https://www.ncbi.nlm.nih.gov/pubmed/35741651
http://dx.doi.org/10.3390/brainsci12060766
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author Stoehr, Kaitlyn
Pazira, Kian
Bonnet, Kemberlee
Schlundt, David
Charles, David
Hacker, Mallory
author_facet Stoehr, Kaitlyn
Pazira, Kian
Bonnet, Kemberlee
Schlundt, David
Charles, David
Hacker, Mallory
author_sort Stoehr, Kaitlyn
collection PubMed
description The deep brain stimulation (DBS) in early-stage Parkinson’s disease (PD) pilot trial began more than a decade ago and remains the only investigation of DBS in mildly symptomatic patients. Patients completed therapeutic washouts biannually for two years, outpatient assessments through five years, and a longitudinal washout assessment after 11 years. Here, the patient experience of participating in the early DBS pilot trial is described. Semi-structured interviews were audio-recorded and transcribed. Transcripts were coded, analyzed using an iterative inductive-deductive approach, and used to develop a conceptual framework. Ten participants (n = 6 early optimal drug therapy (ODT), n = 4 early DBS + ODT) were interviewed. Motivations for participation included benefit to future PD patients and potential personal benefit, while hesitations included risk of surgical complications. While early ODT patients who received standard-of-care DBS described significant changes in their functional capacities after surgery, early DBS patients described a maintenance of quality of life that made PD less impactful over an extended period. Patients expressed high satisfaction with trial participation and early DBS. This study suggests that the PD experience with early DBS may notably differ from standard-of-care DBS. The FDA has approved the conduct of a pivotal clinical trial evaluating DBS in early-stage PD (IDEG050016).
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spelling pubmed-92209162022-06-24 Deep Brain Stimulation in Early-Stage Parkinson’s Disease: Patient Experience after 11 Years Stoehr, Kaitlyn Pazira, Kian Bonnet, Kemberlee Schlundt, David Charles, David Hacker, Mallory Brain Sci Article The deep brain stimulation (DBS) in early-stage Parkinson’s disease (PD) pilot trial began more than a decade ago and remains the only investigation of DBS in mildly symptomatic patients. Patients completed therapeutic washouts biannually for two years, outpatient assessments through five years, and a longitudinal washout assessment after 11 years. Here, the patient experience of participating in the early DBS pilot trial is described. Semi-structured interviews were audio-recorded and transcribed. Transcripts were coded, analyzed using an iterative inductive-deductive approach, and used to develop a conceptual framework. Ten participants (n = 6 early optimal drug therapy (ODT), n = 4 early DBS + ODT) were interviewed. Motivations for participation included benefit to future PD patients and potential personal benefit, while hesitations included risk of surgical complications. While early ODT patients who received standard-of-care DBS described significant changes in their functional capacities after surgery, early DBS patients described a maintenance of quality of life that made PD less impactful over an extended period. Patients expressed high satisfaction with trial participation and early DBS. This study suggests that the PD experience with early DBS may notably differ from standard-of-care DBS. The FDA has approved the conduct of a pivotal clinical trial evaluating DBS in early-stage PD (IDEG050016). MDPI 2022-06-11 /pmc/articles/PMC9220916/ /pubmed/35741651 http://dx.doi.org/10.3390/brainsci12060766 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Stoehr, Kaitlyn
Pazira, Kian
Bonnet, Kemberlee
Schlundt, David
Charles, David
Hacker, Mallory
Deep Brain Stimulation in Early-Stage Parkinson’s Disease: Patient Experience after 11 Years
title Deep Brain Stimulation in Early-Stage Parkinson’s Disease: Patient Experience after 11 Years
title_full Deep Brain Stimulation in Early-Stage Parkinson’s Disease: Patient Experience after 11 Years
title_fullStr Deep Brain Stimulation in Early-Stage Parkinson’s Disease: Patient Experience after 11 Years
title_full_unstemmed Deep Brain Stimulation in Early-Stage Parkinson’s Disease: Patient Experience after 11 Years
title_short Deep Brain Stimulation in Early-Stage Parkinson’s Disease: Patient Experience after 11 Years
title_sort deep brain stimulation in early-stage parkinson’s disease: patient experience after 11 years
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9220916/
https://www.ncbi.nlm.nih.gov/pubmed/35741651
http://dx.doi.org/10.3390/brainsci12060766
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