Loss of voltage-gated hydrogen channel 1 expression reveals heterogeneous metabolic adaptation to intracellular acidification by T cells

Voltage-gated hydrogen channel 1 (Hvcn1) is a voltage-gated proton channel, which reduces cytosol acidification and facilitates the production of ROS. The increased expression of this channel in some cancers has led to proposing Hvcn1 antagonists as potential therapeutics. While its role in most leu...

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Detalles Bibliográficos
Autores principales: Coe, David, Poobalasingam, Thanushiyan, Fu, Hongmei, Bonacina, Fabrizia, Wang, Guosu, Morales, Valle, Moregola, Annalisa, Mitro, Nico, Cheung, Kenneth C.P., Ward, Eleanor J., Nadkarni, Suchita, Aksentijevic, Dunja, Bianchi, Katiuscia, Norata, Giuseppe Danilo, Capasso, Melania, Marelli-Berg, Federica M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9220931/
https://www.ncbi.nlm.nih.gov/pubmed/35472029
http://dx.doi.org/10.1172/jci.insight.147814

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